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UniProtKB - O32178 (FADN_BACSU)
Protein
Probable 3-hydroxyacyl-CoA dehydrogenase
Gene
fadN
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Involved in the degradation of long-chain fatty acids.
Catalytic activityi
- EC:1.1.1.35
: fatty acid beta-oxidation Pathwayi
This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.
GO - Molecular functioni
- 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
- NAD+ binding Source: InterPro
GO - Biological processi
- fatty acid beta-oxidation Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid degradation, Lipid metabolism |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | BSUB:BSU32840-MONOMER |
UniPathwayi | UPA00659 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:fadN Synonyms:yusL Ordered Locus Names:BSU32840 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000360673 | 1 – 789 | Probable 3-hydroxyacyl-CoA dehydrogenaseAdd BLAST | 789 |
Proteomic databases
jPOSTi | O32178 |
PaxDbi | O32178 |
PRIDEi | O32178 |
Expressioni
Inductioni
Repressed by FadR in the absence of LCFAs (fatty acids of 14-20 carbon atoms). When LCFAs are present in the medium, they are converted to long-chain acyl-CoAs, which antagonize FadR as to its binding to fadR boxes on target DNA and thus derepress transcription.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | COG1024, Bacteria COG1250, Bacteria |
InParanoidi | O32178 |
OMAi | GQGFYKK |
Family and domain databases
InterProi | View protein in InterPro IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR029045, ClpP/crotonase-like_dom_sf IPR001753, Enoyl-CoA_hydra/iso IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 1 hit PF02737, 3HCDH_N, 1 hit PF00378, ECH_1, 1 hit |
SUPFAMi | SSF48179, SSF48179, 2 hits SSF51735, SSF51735, 1 hit SSF52096, SSF52096, 1 hit |
i Sequence
Sequence statusi: Complete.
O32178-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHKHIRKAAV LGSGVMGSGI AAHLANIGIP VLLLDIVPND LTKEEEKKGL
60 70 80 90 100
TKDSSEVRSR LSRQAMKKLL KQKPAPLTSA KNTSYITPGN LEDDAEKLKE
110 120 130 140 150
ADWIIEVVVE NLEVKKKIFA LVDEHRKTGS IVSSNTSGIS VQEMAEGRSD
160 170 180 190 200
DFKAHFLGTH FFNPARYLKL LEIIPIKETD PDILKFMTAF GENVLGKGVV
210 220 230 240 250
TAKDTPNFIA NRIGTYGLLV TVQEMLKGGY QVGEVDSITG PLIGRPKSAT
260 270 280 290 300
FRTLDVVGLD TFAHVARNVY DKADGDEKEV FRIPSFMNDM LEKGWIGSKA
310 320 330 340 350
GQGFYKKEGK TIYELDPVTL TYGERTKMKS PALEAAKQAK GTKAKMKALI
360 370 380 390 400
YSDDRAGRLL WNITSQTLLY SAELLGEIAD DIHAIDQAMK WGFGWELGPF
410 420 430 440 450
EMWDAIGLKQ SAEKLEQLGA DMPGWIKEML DKGNETFYIK ENGTVFYYDR
460 470 480 490 500
GEYRAVKENK KRIHLQALKE TKGVIAKNSG ASLIDLGDDV ALLEFHSKSN
510 520 530 540 550
AIGLDIIQMI HKGLEETERN YKGLVIGNQG KNFCVGANLA MILMEVQDDN
560 570 580 590 600
FLEVDFVIRR FQETMMKIKY SAKPVVAAPF GMTLGGGTEA CLPAARIQAA
610 620 630 640 650
SEAYMGLVES GVGLIPGGGG NKELYINHLR RGHDPMNAAM KTFETIAMAK
660 670 680 690 700
VSASAQEARE MNILKETDQI SVNQDHLLYD AKQLAASLYD TGWRPPVKEK
710 720 730 740 750
VKVPGETGYA ALLLGAEQMK LSGYISEHDF KIAKKLAYVI AGGKVPFGTE
760 770 780
VDEEYLLEIE REAFLSLSGE AKSQARMQHM LVKGKPLRN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009126 Genomic DNA Translation: CAB15273.2 |
PIRi | E70021 |
RefSeqi | NP_391163.1, NC_000964.3 WP_003243831.1, NZ_JNCM01000033.1 |
Genome annotation databases
EnsemblBacteriai | CAB15273; CAB15273; BSU_32840 |
GeneIDi | 937125 |
KEGGi | bsu:BSU32840 |
PATRICi | fig|224308.179.peg.3558 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009126 Genomic DNA Translation: CAB15273.2 |
PIRi | E70021 |
RefSeqi | NP_391163.1, NC_000964.3 WP_003243831.1, NZ_JNCM01000033.1 |
3D structure databases
AlphaFoldDBi | O32178 |
SMRi | O32178 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU32840 |
Proteomic databases
jPOSTi | O32178 |
PaxDbi | O32178 |
PRIDEi | O32178 |
Genome annotation databases
EnsemblBacteriai | CAB15273; CAB15273; BSU_32840 |
GeneIDi | 937125 |
KEGGi | bsu:BSU32840 |
PATRICi | fig|224308.179.peg.3558 |
Phylogenomic databases
eggNOGi | COG1024, Bacteria COG1250, Bacteria |
InParanoidi | O32178 |
OMAi | GQGFYKK |
Enzyme and pathway databases
UniPathwayi | UPA00659 |
BioCyci | BSUB:BSU32840-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR006176, 3-OHacyl-CoA_DH_NAD-bd IPR006108, 3HC_DH_C IPR008927, 6-PGluconate_DH-like_C_sf IPR029045, ClpP/crotonase-like_dom_sf IPR001753, Enoyl-CoA_hydra/iso IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF00725, 3HCDH, 1 hit PF02737, 3HCDH_N, 1 hit PF00378, ECH_1, 1 hit |
SUPFAMi | SSF48179, SSF48179, 2 hits SSF51735, SSF51735, 1 hit SSF52096, SSF52096, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FADN_BACSU | |
Accessioni | O32178Primary (citable) accession number: O32178 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 20, 2009 |
Last sequence update: | January 20, 2009 | |
Last modified: | May 25, 2022 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families