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Entry version 118 (02 Dec 2020)
Sequence version 2 (01 Aug 1999)
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Protein

Protein translocase subunit SecDF

Gene

secDF

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for efficient translocation of secretory pre-proteins under conditions of hypersecretion but is not required for the release of mature proteins from the membrane.1 Publication
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU27650-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.6.4.2, the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein translocase subunit SecDF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:secDF
Ordered Locus Names:BSU27650
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 5Cytoplasmic1 Publication5
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 254Extracellular1 PublicationAdd BLAST228
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 278Cytoplasmic1 Publication3
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 301Extracellular1 Publication2
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 353Cytoplasmic1 PublicationAdd BLAST31
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 380Extracellular1 Publication6
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 453Cytoplasmic1 PublicationAdd BLAST52
Transmembranei454 – 474HelicalSequence analysisAdd BLAST21
Topological domaini475 – 569Extracellular1 PublicationAdd BLAST95
Transmembranei570 – 590HelicalSequence analysisAdd BLAST21
Topological domaini591 – 593Cytoplasmic1 Publication3
Transmembranei594 – 614HelicalSequence analysisAdd BLAST21
Topological domaini615 – 621Extracellular1 Publication7
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 677Cytoplasmic1 PublicationAdd BLAST35
Transmembranei678 – 698HelicalSequence analysisAdd BLAST21
Topological domaini699Extracellular1 Publication1
Transmembranei700 – 720HelicalSequence analysisAdd BLAST21
Topological domaini721 – 737Cytoplasmic1 PublicationAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Cells lacking this gene show a cold-sensitive phenotype and a filamentous morphology.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003844021 – 737Protein translocase subunit SecDFAdd BLAST737

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O32047

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O32047

PRoteomics IDEntifications database

More...
PRIDEi
O32047

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Shows maximal expression at the beginning of post-exponential growth phase and increased expression by glucose in the post-exponential growth phase when cells are cultured on rich medium. Expressed constitutively during growth in minimal medium.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary protein SecDF. Other proteins may also be involved (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU27650

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O32047

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 416SecDAdd BLAST416
Regioni446 – 737SecFAdd BLAST292

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the SecD/SecF family. SecD subfamily.Curated
In the C-terminal section; belongs to the SecD/SecF family. SecF subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0341, Bacteria
COG0342, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O32047

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTVNTGM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O32047

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01463_B, SecD_B, 1 hit
MF_01464_B, SecF_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005791, SecD
IPR022813, SecD/SecF_arch_bac
IPR022645, SecD/SecF_bac
IPR022646, SecD/SecF_CS
IPR005665, SecF_bac

The PANTHER Classification System

More...
PANTHERi
PTHR30081, PTHR30081, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07549, Sec_GG, 1 hit
PF02355, SecD_SecF, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01755, SECFTRNLCASE

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00916, 2A0604s01, 2 hits
TIGR00966, 3a0501s07, 1 hit
TIGR01129, secD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O32047-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKGRLIAFF LFVLLIGTGL GYFTKPAANN ITLGLDLQGG FEVLYDVQPV
60 70 80 90 100
KKGDKITKDV LVSTVEALNR RANVLGVSEP NIQIEGNNRI RVQLAGVTNQ
110 120 130 140 150
NRAREILATE AQLSFRDAND KELLNGADLV ENGAKQTYDS TTNEPIVTIK
160 170 180 190 200
LKDADKFGEV TKKVMKMAPN NQLVIWLDYD KGDSFKKEVQ KEHPKFVSAP
210 220 230 240 250
NVSQELNTTD VKIEGHFTAQ EAKDLASILN AGALPVKLTE KYSTSVGAQF
260 270 280 290 300
GQQALHDTVF AGIVGIAIIF LFMLFYYRLP GLIAVITLSV YIYITLQIFD
310 320 330 340 350
WMNAVLTLPG IAALILGVGM AVDANIITYE RIKEELKLGK SVRSAFRSGN
360 370 380 390 400
RRSFATIFDA NITTIIAAVV LFIFGTSSVK GFATMLILSI LTSFITAVFL
410 420 430 440 450
SRFLLALLVE SRWLDRKKGW FGVNKKHIMD IQDTDENTEP HTPFQKWDFT
460 470 480 490 500
SKRKYFFIFS SAVTVAGIII LLVFRLNLGI DFASGARIEV QSDHKLTTEQ
510 520 530 540 550
VEKDFESLGM DPDTVVLSGE KSNIGVARFV GVPDKETIAK VKTYFKDKYG
560 570 580 590 600
SDPNVSTVSP TVGKELARNA LYAVAIASIG IIIYVSIRFE YKMAIAAIAS
610 620 630 640 650
LLYDAFFIVT FFSITRLEVD VTFIAAILTI IGYSINDTIV TFDRVREHMK
660 670 680 690 700
KRKPKTFADL NHIVNLSLQQ TFTRSINTVL TVVIVVVTLL IFGASSITNF
710 720 730
SIALLVGLLT GVYSSLYIAA QIWLAWKGRE LKKDSAQ
Length:737
Mass (Da):81,654
Last modified:August 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54C397E939779177
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF024506 Genomic DNA Translation: AAC31122.1
AL009126 Genomic DNA Translation: CAB14724.2

Protein sequence database of the Protein Information Resource

More...
PIRi
H69704

NCBI Reference Sequences

More...
RefSeqi
NP_390643.1, NC_000964.3
WP_003245970.1, NZ_JNCM01000036.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB14724; CAB14724; BSU27650

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
937938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU27650

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.3004

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024506 Genomic DNA Translation: AAC31122.1
AL009126 Genomic DNA Translation: CAB14724.2
PIRiH69704
RefSeqiNP_390643.1, NC_000964.3
WP_003245970.1, NZ_JNCM01000036.1

3D structure databases

SMRiO32047
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU27650

Protein family/group databases

TCDBi2.A.6.4.2, the resistance-nodulation-cell division (rnd) superfamily

Proteomic databases

jPOSTiO32047
PaxDbiO32047
PRIDEiO32047

Genome annotation databases

EnsemblBacteriaiCAB14724; CAB14724; BSU27650
GeneIDi937938
KEGGibsu:BSU27650
PATRICifig|224308.179.peg.3004

Phylogenomic databases

eggNOGiCOG0341, Bacteria
COG0342, Bacteria
InParanoidiO32047
OMAiRTVNTGM
PhylomeDBiO32047

Enzyme and pathway databases

BioCyciBSUB:BSU27650-MONOMER

Family and domain databases

HAMAPiMF_01463_B, SecD_B, 1 hit
MF_01464_B, SecF_B, 1 hit
InterProiView protein in InterPro
IPR005791, SecD
IPR022813, SecD/SecF_arch_bac
IPR022645, SecD/SecF_bac
IPR022646, SecD/SecF_CS
IPR005665, SecF_bac
PANTHERiPTHR30081, PTHR30081, 2 hits
PfamiView protein in Pfam
PF07549, Sec_GG, 1 hit
PF02355, SecD_SecF, 2 hits
PRINTSiPR01755, SECFTRNLCASE
TIGRFAMsiTIGR00916, 2A0604s01, 2 hits
TIGR00966, 3a0501s07, 1 hit
TIGR01129, secD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSECDF_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O32047
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: August 1, 1999
Last modified: December 2, 2020
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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