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Protein

HTH-type transcriptional repressor CzrA

Gene

czrA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA.1 Publication

Miscellaneous

Can bind copper. It does not affect DNA binding but it inhibits zinc-mediated regulation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90ZincPROSITE-ProRule annotation1
Metal bindingi92ZincPROSITE-ProRule annotation1
Metal bindingi103ZincPROSITE-ProRule annotation1
Metal bindingi106ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi48 – 71H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciBSUB:BSU19120-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor CzrA
Gene namesi
Name:czrA
Synonyms:yozA
Ordered Locus Names:BSU19120
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003784721 – 107HTH-type transcriptional repressor CzrAAdd BLAST107

Proteomic databases

PaxDbiO31844
PRIDEiO31844

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100010556

Structurei

3D structure databases

ProteinModelPortaliO31844
SMRiO31844
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 107HTH arsR-typePROSITE-ProRule annotationAdd BLAST94

Phylogenomic databases

eggNOGiENOG4105KTU Bacteria
COG0640 LUCA
HOGENOMiHOG000144506
InParanoidiO31844
KOiK22043
OMAiVGMEQSA
PhylomeDBiO31844

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O31844-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEFRETEQS AADLDEETLF LVAQTFKALS DPTRIRILHL LSQGEHAVNG
60 70 80 90 100
IAEKLNLLQS TVSHQLRFLK NLRLVKSRRE GTSIYYSPED EHVLDVLQQM

IHHTQHD
Length:107
Mass (Da):12,379
Last modified:January 1, 1998 - v1
Checksum:i1F5D693B9DBF0ABB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB13804.1
PIRiE69930
RefSeqiNP_389793.1, NC_000964.3
WP_003231284.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB13804; CAB13804; BSU19120
GeneIDi939658
KEGGibsu:BSU19120
PATRICifig|224308.179.peg.2090

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009126 Genomic DNA Translation: CAB13804.1
PIRiE69930
RefSeqiNP_389793.1, NC_000964.3
WP_003231284.1, NZ_JNCM01000036.1

3D structure databases

ProteinModelPortaliO31844
SMRiO31844
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100010556

Proteomic databases

PaxDbiO31844
PRIDEiO31844

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13804; CAB13804; BSU19120
GeneIDi939658
KEGGibsu:BSU19120
PATRICifig|224308.179.peg.2090

Phylogenomic databases

eggNOGiENOG4105KTU Bacteria
COG0640 LUCA
HOGENOMiHOG000144506
InParanoidiO31844
KOiK22043
OMAiVGMEQSA
PhylomeDBiO31844

Enzyme and pathway databases

BioCyciBSUB:BSU19120-MONOMER

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50987 HTH_ARSR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCZRA_BACSU
AccessioniPrimary (citable) accession number: O31844
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
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Main funding by: National Institutes of Health

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