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UniProtKB - O31752 (CDSA_BACSU)
Protein
Phosphatidate cytidylyltransferase
Gene
cdsA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalytic activityi
- EC:2.7.7.41
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate. This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- phosphatidate cytidylyltransferase activity Source: GO_Central
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
BioCyci | BSUB:BSU16540-MONOMER |
SABIO-RKi | O31752 |
UniPathwayi | UPA00557;UER00614 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidate cytidylyltransferase (EC:2.7.7.41)Alternative name(s): CDP-DAG synthase CDP-DG synthase CDP-diacylglycerol synthase Short name: CDS CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CTP:phosphatidate cytidylyltransferase |
Gene namesi | Name:cdsA Ordered Locus Names:BSU16540 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Note: Localized in the septal membrane.1 Publication
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 13 – 33 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 50 – 70 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 110 – 130 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 138 – 158 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 200 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 247 – 267 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090726 | 1 – 269 | Phosphatidate cytidylyltransferaseAdd BLAST | 269 |
Proteomic databases
PaxDbi | O31752 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDS family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG4589, Bacteria |
InParanoidi | O31752 |
OMAi | FTFDEVG |
PhylomeDBi | O31752 |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
i Sequence
Sequence statusi: Complete.
O31752-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDMKQRILT GVLAAIVFLF LVIVGKLPFT ILIYAMGSVA LFELLRMKKL
60 70 80 90 100
KLVSLPGLIG LLLLWMFLLP SQYSFFEADG ISKMEIALFA VLLLLTYTVL
110 120 130 140 150
VKNTFTFDEV GFITLAAIYI GMCFHYFIEI RNLDQYGLTY IFYACVVIWS
160 170 180 190 200
TDSGAYFVGK SLGKRKLWPE ISPNKTVEGF AGGIVIALVL ATIFQLVAQL
210 220 230 240 250
PIPYIYLLLI TLFLSVFGQL GDLVESALKR HYDVKDSGNI LPGHGGILDR
260
FDSFLFVMPF LYFLLALFS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009126 Genomic DNA Translation: CAB13527.1 |
PIRi | G69597 |
RefSeqi | NP_389536.1, NC_000964.3 WP_003231924.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB13527; CAB13527; BSU_16540 |
GeneIDi | 939607 |
KEGGi | bsu:BSU16540 |
PATRICi | fig|224308.43.peg.1749 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009126 Genomic DNA Translation: CAB13527.1 |
PIRi | G69597 |
RefSeqi | NP_389536.1, NC_000964.3 WP_003231924.1, NZ_JNCM01000035.1 |
3D structure databases
AlphaFoldDBi | O31752 |
SMRi | O31752 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU16540 |
Proteomic databases
PaxDbi | O31752 |
Genome annotation databases
EnsemblBacteriai | CAB13527; CAB13527; BSU_16540 |
GeneIDi | 939607 |
KEGGi | bsu:BSU16540 |
PATRICi | fig|224308.43.peg.1749 |
Phylogenomic databases
eggNOGi | COG4589, Bacteria |
InParanoidi | O31752 |
OMAi | FTFDEVG |
PhylomeDBi | O31752 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
BioCyci | BSUB:BSU16540-MONOMER |
SABIO-RKi | O31752 |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDSA_BACSU | |
Accessioni | O31752Primary (citable) accession number: O31752 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families