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UniProtKB - O31751 (ISPT_BACSU)
Protein
Isoprenyl transferase
Gene
uppS
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
UniRule annotationCofactori
Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 40 | UniRule annotation | 1 | |
Metal bindingi | 40 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 45 | SubstrateUniRule annotation | 1 | |
Binding sitei | 53 | SubstrateUniRule annotation | 1 | |
Binding sitei | 57 | SubstrateUniRule annotation | 1 | |
Active sitei | 88 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 89 | SubstrateUniRule annotation | 1 | |
Binding sitei | 91 | SubstrateUniRule annotation | 1 | |
Binding sitei | 208 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 227 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- di-trans,poly-cis-decaprenylcistransferase activity Source: GO_Central
- magnesium ion binding Source: GO_Central
- manganese ion binding Source: GO_Central
- polyprenyltransferase activity Source: GO_Central
GO - Biological processi
- polyprenol biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Transferase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU16530-MONOMER |
SABIO-RKi | O31751 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:uppSUniRule annotation Synonyms:yluA Ordered Locus Names:BSU16530 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123572 | 1 – 260 | Isoprenyl transferaseAdd BLAST | 260 |
Proteomic databases
PaxDbi | O31751 |
PRIDEi | O31751 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 224308.BSU16530 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 44 | Substrate bindingUniRule annotation | 4 | |
Regioni | 85 – 87 | Substrate bindingUniRule annotation | 3 | |
Regioni | 214 – 216 | Substrate bindingUniRule annotation | 3 |
Sequence similaritiesi
Belongs to the UPP synthase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0020, Bacteria |
InParanoidi | O31751 |
OMAi | PRTEGHK |
PhylomeDBi | O31751 |
Family and domain databases
CDDi | cd00475, Cis_IPPS, 1 hit |
Gene3Di | 3.40.1180.10, 1 hit |
HAMAPi | MF_01139, ISPT, 1 hit |
InterProi | View protein in InterPro IPR001441, UPP_synth-like IPR018520, UPP_synth-like_CS IPR036424, UPP_synth-like_sf |
PANTHERi | PTHR10291, PTHR10291, 1 hit |
Pfami | View protein in Pfam PF01255, Prenyltransf, 1 hit |
SUPFAMi | SSF64005, SSF64005, 1 hit |
TIGRFAMsi | TIGR00055, uppS, 1 hit |
PROSITEi | View protein in PROSITE PS01066, UPP_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
O31751-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNILKNWKN QQTAASNLER YTKEDILKGE IPEHIAIIMD GNGRWAKKRS
60 70 80 90 100
LPRIAGHHEG MKVVKRTTKL ANELGVKVLT LYAFSTENWK RPKMEVDFLM
110 120 130 140 150
KLPEEFLNTY LPELVEENVQ VRIIGDETAL PAHTLRAIEK AVQDTAQNDG
160 170 180 190 200
MILNFALNYG GRTEIVSAAK SLAEKVKEGS LNIEDIDESL FSTYLMTESL
210 220 230 240 250
QDPELLIRTS GEIRLSNFML WQVAYSEFVF TDVLWPDFKE DHFLQALGEF
260
QQRGRRFGGI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009126 Genomic DNA Translation: CAB13526.1 |
PIRi | A69881 |
RefSeqi | NP_389535.1, NC_000964.3 WP_003231925.1, NZ_JNCM01000035.1 |
Genome annotation databases
EnsemblBacteriai | CAB13526; CAB13526; BSU_16530 |
GeneIDi | 939640 |
KEGGi | bsu:BSU16530 |
PATRICi | fig|224308.179.peg.1794 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009126 Genomic DNA Translation: CAB13526.1 |
PIRi | A69881 |
RefSeqi | NP_389535.1, NC_000964.3 WP_003231925.1, NZ_JNCM01000035.1 |
3D structure databases
SMRi | O31751 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU16530 |
Proteomic databases
PaxDbi | O31751 |
PRIDEi | O31751 |
Genome annotation databases
EnsemblBacteriai | CAB13526; CAB13526; BSU_16530 |
GeneIDi | 939640 |
KEGGi | bsu:BSU16530 |
PATRICi | fig|224308.179.peg.1794 |
Phylogenomic databases
eggNOGi | COG0020, Bacteria |
InParanoidi | O31751 |
OMAi | PRTEGHK |
PhylomeDBi | O31751 |
Enzyme and pathway databases
BioCyci | BSUB:BSU16530-MONOMER |
SABIO-RKi | O31751 |
Family and domain databases
CDDi | cd00475, Cis_IPPS, 1 hit |
Gene3Di | 3.40.1180.10, 1 hit |
HAMAPi | MF_01139, ISPT, 1 hit |
InterProi | View protein in InterPro IPR001441, UPP_synth-like IPR018520, UPP_synth-like_CS IPR036424, UPP_synth-like_sf |
PANTHERi | PTHR10291, PTHR10291, 1 hit |
Pfami | View protein in Pfam PF01255, Prenyltransf, 1 hit |
SUPFAMi | SSF64005, SSF64005, 1 hit |
TIGRFAMsi | TIGR00055, uppS, 1 hit |
PROSITEi | View protein in PROSITE PS01066, UPP_SYNTHASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ISPT_BACSU | |
Accessioni | O31751Primary (citable) accession number: O31751 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families