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UniProtKB - O31461 (ILVE1_BACSU)

Entry version 137 (07 Apr 2021)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
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Protein

Branched-chain-amino-acid transaminase 1

Gene

ilvE

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transaminates branched-chain amino acids and ketoglutarate. Involved in the final step of the methionine regeneration pathway, where ketomethiobutyrate (KMTB) is converted to methionine via a transamination. The amino donor preference is isoleucine, leucine, valine, phenylalanine, and tyrosine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by canaline.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.36 mM for isoleucine (with 10 mM ketomethiobutyrate)1 Publication
  2. KM=2.78 mM for leucine (with 10 mM ketomethiobutyrate)1 Publication
  3. KM=2.82 mM for valine (with 10 mM alpha-ketoglutarate)1 Publication
  4. KM=3.15 mM for isoleucine (with 10 mM alpha-ketoglutarate)1 Publication
  5. KM=3.20 mM for valine (with 10 mM ketomethiobutyrate)1 Publication
  6. KM=3.99 mM for leucine (with 10 mM alpha-ketoglutarate)1 Publication
  1. Vmax=1.84 µmol/min/mg enzyme toward isoleucine (with 10 mM ketomethiobutyrate)1 Publication
  2. Vmax=1.87 µmol/min/mg enzyme toward leucine (with 10 mM ketomethiobutyrate)1 Publication
  3. Vmax=2.03 µmol/min/mg enzyme toward valine (with 10 mM ketomethiobutyrate)1 Publication
  4. Vmax=13.93 µmol/min/mg enzyme toward valine (with 10 mM alpha-ketoglutarate)1 Publication
  5. Vmax=14.58 µmol/min/mg enzyme toward leucine (with 10 mM alpha-ketoglutarate)1 Publication
  6. Vmax=16.61 µmol/min/mg enzyme toward isoleucine (with 10 mM alpha-ketoglutarate)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (ilvN), Acetolactate synthase (ilvB), Acetolactate synthase large subunit (ilvB), Acetolactate synthase small subunit (ilvH)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC), Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (HIR78_22035), Branched-chain-amino-acid transaminase 1 (ilvE), Branched-chain-amino-acid aminotransferase 2 (ilvK)
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-leucine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. 2-isopropylmalate synthase (leuA), 2-isopropylmalate synthase (leuA)
  2. 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase small subunit (leuD), 3-isopropylmalate dehydratase large subunit (leuC), 3-isopropylmalate dehydratase large subunit (leuC)
  3. 3-isopropylmalate dehydrogenase (leuB), 3-isopropylmalate dehydrogenase (leuB)
  4. Branched-chain-amino-acid aminotransferase (HIR78_22035), Branched-chain-amino-acid transaminase 1 (ilvE), Branched-chain-amino-acid aminotransferase 2 (ilvK)
This subpathway is part of the pathway L-leucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-leucine from 3-methyl-2-oxobutanoate, the pathway L-leucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-valine from pyruvate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase (ilvN), Acetolactate synthase (ilvB), Acetolactate synthase large subunit (ilvB), Acetolactate synthase small subunit (ilvH)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC), Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD), Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (HIR78_22035), Branched-chain-amino-acid transaminase 1 (ilvE), Branched-chain-amino-acid aminotransferase 2 (ilvK)
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		BSUB:BSU02390-MONOMER

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		O31461

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00047;UER00058
UPA00048;UER00073
UPA00049;UER00062

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Branched-chain-amino-acid transaminase 1 (EC:2.6.1.42)
Short name:
BCAT 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ilvE
Synonyms:ybgE
Ordered Locus Names:BSU02390
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001032881 – 356Branched-chain-amino-acid transaminase 1Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei197N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O31461

PRoteomics IDEntifications database

More...PRIDEi		O31461

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		224308.BSU02390

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O31461

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0115, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O31461

Identification of Orthologs from Complete Genome Data

More...OMAi		YFTDYMF

Database for complete collections of gene phylogenies

More...PhylomeDBi		O31461

Family and domain databases

Conserved Domains Database

More...CDDi		cd01557, BCAT_beta_family, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.10.10, 1 hit
3.30.470.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001544, Aminotrans_IV
IPR018300, Aminotrans_IV_CS
IPR036038, Aminotransferase-like
IPR005786, B_amino_transII
IPR043132, BCAT-like_C
IPR043131, BCAT-like_N
IPR033939, BCAT_family

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01063, Aminotran_4, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF006468, BCAT1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56752, SSF56752, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01123, ilvE_II, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00770, AA_TRANSFER_CLASS_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O31461-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKLIEREKT VYYKEKPDPS SLGFGQYFTD YMFVMDYEEG IGWHHPRIAP 
        60         70         80         90        100
YAPLTLDPSS SVFHYGQAVF EGLKAYRTDD GRVLLFRPDQ NIKRLNRSCE 
       110        120        130        140        150
RMSMPPLDEE LVLEALTQLV ELEKDWVPKE KGTSLYIRPF VIATEPSLGV 
       160        170        180        190        200
KASRSYTFMI VLSPVGSYYG DDQLKPVRIY VEDEYVRAVN GGVGFAKTAG 
       210        220        230        240        250
NYAASLQAQR KANELGYDQV LWLDAIEKKY VEEVGSMNIF FVINGEAVTP 
       260        270        280        290        300
ALSGSILSGV TRASAIELIR SWGIPVREER ISIDEVYAAS ARGELTEVFG 
       310        320        330        340        350
TGTAAVVTPV GELNIHGKTV IVGDGQIGDL SKKLYETITD IQLGKVKGPF 

NWTVEV
Length:356
Mass (Da):39,676
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6591FC3168887DEE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB006424 Genomic DNA Translation: BAA33137.1
AL009126 Genomic DNA Translation: CAB12033.1

Protein sequence database of the Protein Information Resource

More...PIRi		H69750

NCBI Reference Sequences

More...RefSeqi		NP_388121.1, NC_000964.3
WP_003246499.1, NZ_JNCM01000030.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CAB12033; CAB12033; BSU_02390

Database of genes from NCBI RefSeq genomes

More...GeneIDi		938420

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bsu:BSU02390

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|224308.179.peg.245

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006424 Genomic DNA Translation: BAA33137.1
AL009126 Genomic DNA Translation: CAB12033.1
PIRiH69750
RefSeqiNP_388121.1, NC_000964.3
WP_003246499.1, NZ_JNCM01000030.1

3D structure databases

SMRiO31461
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU02390

Proteomic databases

PaxDbiO31461
PRIDEiO31461

Genome annotation databases

EnsemblBacteriaiCAB12033; CAB12033; BSU_02390
GeneIDi938420
KEGGibsu:BSU02390
PATRICifig|224308.179.peg.245

Phylogenomic databases

eggNOGiCOG0115, Bacteria
InParanoidiO31461
OMAiYFTDYMF
PhylomeDBiO31461

Enzyme and pathway databases

UniPathwayiUPA00047;UER00058
UPA00048;UER00073
UPA00049;UER00062
BioCyciBSUB:BSU02390-MONOMER
SABIO-RKiO31461

Family and domain databases

CDDicd01557, BCAT_beta_family, 1 hit
Gene3Di3.20.10.10, 1 hit
3.30.470.10, 1 hit
InterProiView protein in InterPro
IPR001544, Aminotrans_IV
IPR018300, Aminotrans_IV_CS
IPR036038, Aminotransferase-like
IPR005786, B_amino_transII
IPR043132, BCAT-like_C
IPR043131, BCAT-like_N
IPR033939, BCAT_family
PfamiView protein in Pfam
PF01063, Aminotran_4, 1 hit
PIRSFiPIRSF006468, BCAT1, 1 hit
SUPFAMiSSF56752, SSF56752, 1 hit
TIGRFAMsiTIGR01123, ilvE_II, 1 hit
PROSITEiView protein in PROSITE
PS00770, AA_TRANSFER_CLASS_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiILVE1_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O31461
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: April 7, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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