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Protein

Sporulation-killing factor biosynthesis protein SkfC

Gene

skfC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for production of the bacteriocin SkfA.1 Publication

Miscellaneous

Accelerated cannibalism by skf- cells is seen on solid media but not in liquid media.1 Publication

GO - Biological processi

Keywordsi

Biological processAntibiotic biosynthesis, Bacteriocin biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU01935-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-killing factor biosynthesis protein SkfC
Gene namesi
Name:skfC1 Publication
Synonyms:skfD, ybcS, ybcT
Ordered Locus Names:BSU01935
ORF Names:BSU01930, BSU01940
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

When the skfA-skfB-skfC-skfE-skfF-skfG-skfH operon is deleted, increased rate of spore formation; a double operon deletion (sdpA-sdpC plus skfA-skfH) makes spores even faster (PubMed:12817086).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000136901 – 496Sporulation-killing factor biosynthesis protein SkfCAdd BLAST496

Proteomic databases

PaxDbiO31425
PRIDEiO31425

Expressioni

Inductioni

By Spo0A (PubMed:12817086) and PhoP, during nutrient starvation, especially phosphate starvation. Repressed by AbrB during normal growth when nutrients are plentiful, in association with the transcriptional repressor Abh.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100001093

Structurei

3D structure databases

ProteinModelPortaliO31425
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41066N6 Bacteria
ENOG411294V LUCA

Family and domain databases

InterProiView protein in InterPro
IPR003675 CAAX_protease
PfamiView protein in Pfam
PF02517 Abi, 1 hit

Sequencei

Sequence statusi: Complete.

O31425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLSLVFWS ILAVVGLLLF IKFKPPTIAS LLLSKDEAKE ISIQFIKEFV
60 70 80 90 100
GIDVENWDFY SVYWYDHDTV NKLHHLGILK KNRKVLYDVG LVESWRVRFV
110 120 130 140 150
HQNQSFVVGV NANREITFFY ADVPKKTLSG KFEQVSPETL KQRLMASPDG
160 170 180 190 200
LWSRANMTGT GKKEEDFREV STYWYIAEAG DIRLKVTVEL QGGRISYIGT
210 220 230 240 250
EQEILTDQMS KVIRDEQVES TFGVSGMLGS ALAMILAILI LVFMDVQTSI
260 270 280 290 300
IFSLVLGLLI IICQSLTLKE DIQLTIVNAY DARMSVKTVS LLGILSTLLT
310 320 330 340 350
GLLTGFVVFI CSLAGNALAG DFGWKTFEQP IVQIFYGIGA GLISLGVTSL
360 370 380 390 400
LFNLLEKKQY LRISPELSNR TVFLSGFTFR QGLNMSIQSS IGEEVIYRLL
410 420 430 440 450
MIPVIWWMSG NILISIIVSS FLWAVMHQVT GYDPRWIRWL HLFIFGCFLG
460 470 480 490
VLFIKFGFIC VLVAHFIHNL VLVCMPLWQF KLQKHMHHDQ PKHTSL
Length:496
Mass (Da):56,292
Last modified:November 24, 2009 - v2
Checksum:i2380A24F80381171
GO

Sequence cautioni

The sequence BAA33090 differs from that shown. Reason: Frameshift at position 180.Curated
The sequence BAA33091 differs from that shown. Reason: Frameshift at position 180.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006424 Genomic DNA Translation: BAA33090.1 Frameshift.
AB006424 Genomic DNA Translation: BAA33091.1 Frameshift.
AL009126 Genomic DNA Translation: CAX52541.1
PIRiF69746
G69746
RefSeqiWP_003246417.1, NZ_JNCM01000030.1
YP_003097671.1, NC_000964.3

Genome annotation databases

EnsemblBacteriaiCAX52541; CAX52541; BSU01935
GeneIDi8302931
KEGGibsu:BSU01935
PATRICifig|224308.179.peg.200

Similar proteinsi

Entry informationi

Entry nameiSKFC_BACSU
AccessioniPrimary (citable) accession number: O31425
Secondary accession number(s): C0H3T0, O31426, Q7DL63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: November 24, 2009
Last modified: June 20, 2018
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

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