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UniProtKB - O31425 (SKFC_BACSU)
Protein
Sporulation-killing factor biosynthesis protein SkfC
Gene
skfC
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Required for production of the bacteriocin SkfA.
1 PublicationMiscellaneous
Accelerated cannibalism by skf- cells is seen on solid media but not in liquid media.1 Publication
GO - Molecular functioni
- metalloendopeptidase activity Source: InterPro
GO - Biological processi
- bacteriocin biosynthetic process Source: UniProtKB-KW
- CAAX-box protein processing Source: InterPro
Keywordsi
Biological process | Antibiotic biosynthesis, Bacteriocin biosynthesis |
Enzyme and pathway databases
BioCyci | BSUB:BSU01935-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Sporulation-killing factor biosynthesis protein SkfC |
Gene namesi | Name:skfC1 Publication Synonyms:skfD, ybcS, ybcT Ordered Locus Names:BSU01935 ORF Names:BSU01930, BSU01940 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 248 – 268 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 291 – 311 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 331 – 351 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 399 – 419 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 443 – 463 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Disruption phenotypei
When the skfA-skfB-skfC-skfE-skfF-skfG-skfH operon is deleted, increased rate of spore formation; a double operon deletion (sdpA-sdpC plus skfA-skfH) makes spores even faster (PubMed:12817086).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000013690 | 1 – 496 | Sporulation-killing factor biosynthesis protein SkfCAdd BLAST | 496 |
Proteomic databases
PaxDbi | O31425 |
Expressioni
Inductioni
By Spo0A (PubMed:12817086) and PhoP, during nutrient starvation, especially phosphate starvation. Repressed by AbrB during normal growth when nutrients are plentiful, in association with the transcriptional repressor Abh.2 Publications
Structurei
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1266, Bacteria |
Family and domain databases
InterProi | View protein in InterPro IPR003675, Rce1-like |
Pfami | View protein in Pfam PF02517, Rce1-like, 1 hit |
i Sequence
Sequence statusi: Complete.
O31425-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSLSLVFWS ILAVVGLLLF IKFKPPTIAS LLLSKDEAKE ISIQFIKEFV
60 70 80 90 100
GIDVENWDFY SVYWYDHDTV NKLHHLGILK KNRKVLYDVG LVESWRVRFV
110 120 130 140 150
HQNQSFVVGV NANREITFFY ADVPKKTLSG KFEQVSPETL KQRLMASPDG
160 170 180 190 200
LWSRANMTGT GKKEEDFREV STYWYIAEAG DIRLKVTVEL QGGRISYIGT
210 220 230 240 250
EQEILTDQMS KVIRDEQVES TFGVSGMLGS ALAMILAILI LVFMDVQTSI
260 270 280 290 300
IFSLVLGLLI IICQSLTLKE DIQLTIVNAY DARMSVKTVS LLGILSTLLT
310 320 330 340 350
GLLTGFVVFI CSLAGNALAG DFGWKTFEQP IVQIFYGIGA GLISLGVTSL
360 370 380 390 400
LFNLLEKKQY LRISPELSNR TVFLSGFTFR QGLNMSIQSS IGEEVIYRLL
410 420 430 440 450
MIPVIWWMSG NILISIIVSS FLWAVMHQVT GYDPRWIRWL HLFIFGCFLG
460 470 480 490
VLFIKFGFIC VLVAHFIHNL VLVCMPLWQF KLQKHMHHDQ PKHTSL
Sequence cautioni
The sequence BAA33090 differs from that shown. Reason: Frameshift.Curated
The sequence BAA33091 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006424 Genomic DNA Translation: BAA33090.1 Frameshift. AB006424 Genomic DNA Translation: BAA33091.1 Frameshift. AL009126 Genomic DNA Translation: CAX52541.1 |
PIRi | F69746 G69746 |
RefSeqi | WP_003246417.1, NZ_JNCM01000030.1 YP_003097671.1, NC_000964.3 |
Genome annotation databases
EnsemblBacteriai | CAX52541; CAX52541; BSU_01935 |
GeneIDi | 8302931 |
KEGGi | bsu:BSU01935 |
PATRICi | fig|224308.179.peg.200 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006424 Genomic DNA Translation: BAA33090.1 Frameshift. AB006424 Genomic DNA Translation: BAA33091.1 Frameshift. AL009126 Genomic DNA Translation: CAX52541.1 |
PIRi | F69746 G69746 |
RefSeqi | WP_003246417.1, NZ_JNCM01000030.1 YP_003097671.1, NC_000964.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 224308.BSU01935 |
Proteomic databases
PaxDbi | O31425 |
Genome annotation databases
EnsemblBacteriai | CAX52541; CAX52541; BSU_01935 |
GeneIDi | 8302931 |
KEGGi | bsu:BSU01935 |
PATRICi | fig|224308.179.peg.200 |
Phylogenomic databases
eggNOGi | COG1266, Bacteria |
Enzyme and pathway databases
BioCyci | BSUB:BSU01935-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR003675, Rce1-like |
Pfami | View protein in Pfam PF02517, Rce1-like, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SKFC_BACSU | |
Accessioni | O31425Primary (citable) accession number: O31425 Secondary accession number(s): C0H3T0, O31426, Q7DL63 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2003 |
Last sequence update: | November 24, 2009 | |
Last modified: | February 23, 2022 | |
This is version 89 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |