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Protein

Alcohol dehydrogenase

Gene

adhA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc; catalyticBy similarity1
Metal bindingi63Zinc; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:adhA
Ordered Locus Names:RA0704
ORF Names:SMa1296
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000001976 Componenti: Plasmid pSymA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607481 – 340Alcohol dehydrogenaseAdd BLAST340

Structurei

3D structure databases

ProteinModelPortaliO31186
SMRiO31186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685
KOiK13953
OMAiARIPKEC

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

O31186-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMTAAVVRE FGKPLVIEEV PVPQPGPGQV LIKYEATGVC HTDLHAAKGD
60 70 80 90 100
WPVRPNPPFI PGHEGVGYVA KLGAEVTRLK EGDRVGVPWL HTACGCCTPC
110 120 130 140 150
RTGWETLCGS QQNTGYSVDG TFAQYGLADP DFVGRLPARL EFGPAAPVLC
160 170 180 190 200
AGVTVYKGLK ETEVRPGEWV LVSGIGGLGH MAVQYAKAMG MHVAAADIFP
210 220 230 240 250
DKLALAEKLG ADLVVDARAP DAVEEVQRRT GGLHGALVTA VSPKAMEQAY
260 270 280 290 300
SMLRSKGTMA LVGLPPGQIC LPVFDTVLKR ITVRGSIVGT RQDLEEALEF
310 320 330 340
AGEGKVAAHF SWDKIENINA IFERMEEGKI DGRIVLDLNG
Length:340
Mass (Da):36,235
Last modified:January 1, 1998 - v1
Checksum:iC1A04B5FEE5C95E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031940 Genomic DNA Translation: AAB87463.1
AE006469 Genomic DNA Translation: AAK65362.1
PIRiH95349
RefSeqiNP_435950.1, NC_003037.1
WP_010967682.1, NC_003037.1

Genome annotation databases

EnsemblBacteriaiAAK65362; AAK65362; SMa1296
GeneIDi1235740
25012428
KEGGisme:SMa1296
PATRICifig|266834.11.peg.726

Similar proteinsi

Entry informationi

Entry nameiADHA_RHIME
AccessioniPrimary (citable) accession number: O31186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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