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Entry version 103 (22 Apr 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Tyrocidine synthase 2

Gene

tycB

Organism
Brevibacillus parabrevis
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates the second to fourth amino acids in tyrocidine (in tyrocidine A, Pro, Phe, and D-Phe) and epimerizes the last one.

Miscellaneous

Tyrocidine is a mixture of four cyclic decapeptides, tyrocidine A (D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu), B, C, and D, in which Phe, at positions 3, 4, and Tyr residues are gradually replaced by Trp, depending on the relative concentrations of these amino acids in the growth medium.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 3 phosphopantetheines covalently.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tyrocidine biosynthesis

This protein is involved in the pathway tyrocidine biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway tyrocidine biosynthesis and in Antibiotic biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase, Multifunctional enzyme
Biological processAntibiotic biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O30408

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00180

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrocidine synthase 2
Alternative name(s):
Tyrocidine synthase II
Including the following 4 domains:
ATP-dependent proline adenylase
Short name:
ProA
Alternative name(s):
Proline activase
ATP-dependent phenylalanine adenylase
Short name:
PheA
Alternative name(s):
Phenylalanine activase
ATP-dependent D-phenylalanine adenylase
Short name:
D-PheA
Alternative name(s):
D-phenylalanine activase
Phenylalanine racemase [ATP-hydrolyzing] (EC:5.1.1.11)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tycB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrevibacillus parabrevis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri54914 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930941 – 3587Tyrocidine synthase 2Add BLAST3587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1007O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2042O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3075O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O30408

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Large multienzyme complex of TycA, TycB and TycC.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13587
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O30408

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini972 – 1047Carrier 1PROSITE-ProRule annotationAdd BLAST76
Domaini2007 – 2082Carrier 2PROSITE-ProRule annotationAdd BLAST76
Domaini3040 – 3114Carrier 3PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni466 – 1045Domain 1 (Proline-activating)Add BLAST580
Regioni1522 – 2081Domain 2 (Phenylalanine-activating)Add BLAST560
Regioni2540 – 3122Domain 3 (D-phenylalanine-activating)Add BLAST583

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of three modules, including a C-terminal epimerization domain. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional), and N methylation (optional).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K16123

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 3 hits
3.30.559.10, 4 hits
3.40.50.12780, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 3 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 3 hits
TIGR01720, NRPS-para261, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O30408-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVFSKEQVQ DMYALTPMQE GMLFHALLDQ EHNSHLVQMS ISLQGDLDVG
60 70 80 90 100
LFTDSLHVLV ERYDVFRTLF LYEKLKQPLQ VVLKQRPIPI EFYDLSACDE
110 120 130 140 150
SEKQLRYTQY KRADQERTFH LAKDPLMRVA LFQMSQHDYQ VIWSFHHILM
160 170 180 190 200
DGWCFSIIFD DLLAIYLSLQ NKTALSLEPV QPYSRFINWL EKQNKQAALN
210 220 230 240 250
YWSDYLEAYE QKTTLPKKEA AFAKAFQPTQ YRFSLNRTLT KQLGTIASQN
260 270 280 290 300
QVTLSTVIQT IWGVLLQKYN AAHDVLFGSV VSGRPTDIVG IDKMVGLFIN
310 320 330 340 350
TIPFRVQAKA GQTFSELLQA VHKRTLQSQP YEHVPLYDIQ TQSVLKQELI
360 370 380 390 400
DHLLVIENYP LVEALQKKAL NQQIGFTITA VEMFEPTNYD LTVMVMPKEE
410 420 430 440 450
LAFRFDYNAA LFDEQVVQKL AGHLQQIADC VANNSGVELC QIPLLTEAET
460 470 480 490 500
SQLLAKRTET AADYPAATMH ELFSRQAEKT PEQVAVVFAD QHLTYRELDE
510 520 530 540 550
KSNQLARFLR KKGIGTGSLV GTLLDRSLDM IVGILGVLKA GGAFVPIDPE
560 570 580 590 600
LPAERIAYML THSRVPLVVT QNHLRAKVTT PTETIDINTA VIGEESRAPI
610 620 630 640 650
ESLNQPHDLF YIIYTSGTTG QPKGVMLEHR NMANLMHFTF DQTNIAFHEK
660 670 680 690 700
VLQYTTCSFD VCYQEIFSTL LSGGQLYLIT NELRRHVEKL FAFIQEKQIS
710 720 730 740 750
ILSLPVSFLK FIFNEQDYAQ SFPRCVKHII TAGEQLVVTH ELQKYLRQHR
760 770 780 790 800
VFLHNHYGPS ETHVVTTCTM DPGQAIPELP PIGKPISNTG IYILDEGLQL
810 820 830 840 850
KPEGIVGELY ISGANVGRGY LHQPELTAEK FLDNPYQPGE RMYRTGDLAL
860 870 880 890 900
WLPDGQLEFL GRIDHQVKIR GHRIELGEIE SRLLNHPAIK EAVVIDRADE
910 920 930 940 950
TGGKFLCAYV VLQKALSDEE MRAYLAQALP EYMIPSFFVT LERIPVTPNG
960 970 980 990 1000
KTDRRALPKP EGSAKTKADY VAPTTELEQK LVAIWEQILG VSPIGIQDHF
1010 1020 1030 1040 1050
FTLGGHSLKA IQLISRIQKE CQADVPLRVL FEQPTIQALA AYVEGGEESA
1060 1070 1080 1090 1100
YLAIPQAEPQ AYYPVSSAQK RMLILNQLDP HSTVYNLPVA MILEGTLDKA
1110 1120 1130 1140 1150
RLEHAISNLV ARHESLRTSF HTINGEPVSR IHEQGHLPIV YLETAEEQVN
1160 1170 1180 1190 1200
EVILGFMQPF DLVTAPLCRV GLVKLAENRH VLIIDMHHII SDGVSSQLIL
1210 1220 1230 1240 1250
NDFSRLYQNK ALPEQRIHYK DFAVWEKAWT QTTDYQKQEK YWLDRFAGEI
1260 1270 1280 1290 1300
PVLNLPMDYP RPAVQSFEGE RYLFRTEKQL LESLQDVAQK TGTTLYMVLL
1310 1320 1330 1340 1350
AAYHVLLSKY SGQDDVMIGT VTAGRVHPDT ESMTGMFVNT LAMRNQSAPT
1360 1370 1380 1390 1400
KTFRQFLLEV KDNTLAAFEH GQYPFEELVE KLAIQRNRSR NPLFDTLFIL
1410 1420 1430 1440 1450
QNMDADLIEL DGLTVTPYVP EGEVAKFDLS LEASENQAGL SFCFEFCTKL
1460 1470 1480 1490 1500
FARETIERMS LHYLQILQAV SANTEQELAQ IEMLTAHEKQ ELLVHFNDTA
1510 1520 1530 1540 1550
ALYPAESTLS QLFEDQAQKT PEQTAVVFGD KRLTYRELNE RANQLAHTLR
1560 1570 1580 1590 1600
AKGVQAEQSV GIMAQRSLEM AIGIIAILKA GGAYVPIDPD YPNERIAYML
1610 1620 1630 1640 1650
EDCRRLVLTQ QQLAEKMTAN VECLYLDEEG SYSPQTENIE PIHTAADLAY
1660 1670 1680 1690 1700
IIYTSGTTGR PKGVMVEHRG IVNSVTWNRD EFALSVRDSG TLSLSFAFDA
1710 1720 1730 1740 1750
FALTFFTLIV SGSTVVLMPD HEAKDPIALR NLIAAWECSY VVFVPSMFQA
1760 1770 1780 1790 1800
ILECSTPADI RSIQAVMLGG EKLSPKLVQL CKAMHPQMSV MNAYGPTESS
1810 1820 1830 1840 1850
VMATYLRDTQ PDQPITIGRP IANTAIYIVD QHHQLLPVGV VGEICIGGHG
1860 1870 1880 1890 1900
LARGYWKKPE LTAEKFVANP AVPGERMYKT GDLGRWLHDG TIDFIGRVDD
1910 1920 1930 1940 1950
QIKVRGYRIE VGEIEAVLLA YDQTNEAIVV AYQDDRGDSY LAAYVTGKTA
1960 1970 1980 1990 2000
IEESELRAHL LRELPAYMVP TYLIQLDAFP LTPNGKVDRK ALPKPEGKPA
2010 2020 2030 2040 2050
TGAAYVAPAT EVEAKLVAIW ENALGISGVG VLDHFFELGG HSLKAMTVVA
2060 2070 2080 2090 2100
QVHREFQIDL LLKQFFAAPT IRDLARLIEH SEQAAGAAIQ PAEPQAYYPV
2110 2120 2130 2140 2150
SSAQQRMYLL HQLEGAGISY NTPGIIMLEG KLDREQLANA LQALVDRHDI
2160 2170 2180 2190 2200
LRTSFEMVGD ELVQKIHDRV AVNMEYVTAE EQQIDDLFHA FVRPFDLSVP
2210 2220 2230 2240 2250
PLLRMSLVKL ADERHLLLYD MHHIAADAAS ITILFDELAE LYQGRELPEM
2260 2270 2280 2290 2300
RIQYKDFAVW QKALHESDAF KQQEAYWLST FAGNITAVDV PTDFPRPAVK
2310 2320 2330 2340 2350
SFAGGQVTLS MDQELLSALH ELAAHTNTTL FMVLLAAYNV LLAKYAGQDD
2360 2370 2380 2390 2400
IIVGTPISGR SRAELAPVVG MFVHTLAIRN KPTAEKTFKQ FLQEVKQNAL
2410 2420 2430 2440 2450
DAFDHQDYPF ESLVEKLGIP RDPGRNPLFD TMFILQNDEL HAKTLDQLVY
2460 2470 2480 2490 2500
RPYESDSALD VAKFDLSFHL TERETDLFLR LEYCTKLFKQ QTVERMAHHF
2510 2520 2530 2540 2550
LQILRAVTAN PENELQEIEM LTAAEKQMLL VAFNDTHREY RADQTIQQLF
2560 2570 2580 2590 2600
EELAEKMPEH TALVFEEKRM SFRELNERAN QLAAVLREKG VGPAQIVALL
2610 2620 2630 2640 2650
VERSAEMVIA TLATLKAGGA FLPVDPDYPE ERIRYMLEDS QAKLVVTHAH
2660 2670 2680 2690 2700
LLHKVSSQSE VVDVDDPGSY ATQTDNLPCA NTPSDLAYII YTSGTTGKPK
2710 2720 2730 2740 2750
GVMLEHKGVA NLQAVFAHHL GVTPQDRAGH FASISFDASV WDMFGPLLSG
2760 2770 2780 2790 2800
ATLYVLSRDV INDFQRFAEY VRDNAITFLT LPPTYAIYLE PEQVPSLRTL
2810 2820 2830 2840 2850
ITAGSASSVA LVDKWKEKVT YVNGYGPTES TVCATLWKAK PDEPVETITI
2860 2870 2880 2890 2900
GKPIQNTKLY IVDDQLQLKA PGQMGELCIS GLSLARGYWN RPELTAEKFV
2910 2920 2930 2940 2950
DNPFVPGTKM YRTGDLARWL PDGTIEYLGR IDHQVKIRGH RVELGEVESV
2960 2970 2980 2990 3000
LLRYDTVKEA AAITHEDDRG QAYLCAYYVA EGEATPAQLR AYMENELPNY
3010 3020 3030 3040 3050
MVPAFFIQLE KMPLTPNDKI DRKALPKPNQ EENRTEQYAA PQTELEQLLA
3060 3070 3080 3090 3100
GIWADVLGIK QVGTQDNFFE LGGDSIKAIQ VSTRLNASGW TLAMKELFQY
3110 3120 3130 3140 3150
PTIEEAALRV IPNSRESEQG VVEGEIALTP IQKWFFANNF TDRHHWNQAV
3160 3170 3180 3190 3200
MLFREDGFDE GLVRQAFQQI VEHHDALRMV YKQEDGAIKQ INRGLTDERF
3210 3220 3230 3240 3250
RFYSYDLKNH ANSEARILEL SDQIQSSIDL EHGPLVHVAL FATKDGDHLL
3260 3270 3280 3290 3300
VAIHHLVVDG VSWRILFEDF SSAYSQALHQ QEIVLPKKTD SFKDWAAQLQ
3310 3320 3330 3340 3350
KYADSDELLR EVAYWHNLET TTTTAALPTD FVTADRKQKH TRTLSFALTV
3360 3370 3380 3390 3400
PQTENLLRHV HHAYHTEMND LLLTALGLAV KDWAHTNGVV INLEGHGRED
3410 3420 3430 3440 3450
IQNEMNVTRT IGWFTSQYPV VLDMEKAEDL PYQIKQTKEN LRRIPKKGIG
3460 3470 3480 3490 3500
YEILRTLTTS QLQPPLAFTL RPEISFNYLG QFESDGKTGG FTFSPLGTGQ
3510 3520 3530 3540 3550
LFSPESERVF LLDISAMIED GELRISVGYS RLQYEEKTIA SLADSYRKHL
3560 3570 3580
LGIIEHCMAK EEGEYTPSDL GDEELSMEEL ENILEWI
Length:3,587
Mass (Da):404,817
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i322B8471BBB28B47
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF004835 Genomic DNA Translation: AAC45929.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:AAC45929

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004835 Genomic DNA Translation: AAC45929.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5M6PX-ray2.60A/B3113-3587[»]
SMRiO30408
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiO30408

Genome annotation databases

KEGGiag:AAC45929

Phylogenomic databases

KOiK16123

Enzyme and pathway databases

UniPathwayiUPA00180
SABIO-RKiO30408

Family and domain databases

Gene3Di1.10.1200.10, 3 hits
3.30.559.10, 4 hits
3.40.50.12780, 2 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 3 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 3 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 3 hits
SUPFAMiSSF47336, SSF47336, 3 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 3 hits
TIGR01720, NRPS-para261, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYCB_BREPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O30408
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: April 22, 2020
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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