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UniProtKB - O30408 (TYCB_BREPA)

Entry version 109 (23 Feb 2022)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
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Protein

Tyrocidine synthase 2

Gene

tycB

Organism
Brevibacillus parabrevis
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates the second to fourth amino acids in tyrocidine (in tyrocidine A, Pro, Phe, and D-Phe) and epimerizes the last one.

Miscellaneous

Tyrocidine is a mixture of four cyclic decapeptides, tyrocidine A (D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu), B, C, and D, in which Phe, at positions 3, 4, and Tyr residues are gradually replaced by Trp, depending on the relative concentrations of these amino acids in the growth medium.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 3 phosphopantetheines covalently.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tyrocidine biosynthesis

This protein is involved in the pathway tyrocidine biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway tyrocidine biosynthesis and in Antibiotic biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase, Multifunctional enzyme
Biological processAntibiotic biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		O30408

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00180

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrocidine synthase 2
Alternative name(s):
Tyrocidine synthase II
Including the following 4 domains:
ATP-dependent proline adenylase
Short name:
ProA
Alternative name(s):
Proline activase
ATP-dependent phenylalanine adenylase
Short name:
PheA
Alternative name(s):
Phenylalanine activase
ATP-dependent D-phenylalanine adenylase
Short name:
D-PheA
Alternative name(s):
D-phenylalanine activase
Phenylalanine racemase [ATP-hydrolyzing] (EC:5.1.1.11)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tycB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrevibacillus parabrevis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri54914 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Bacilli › Bacillales › Paenibacillaceae › Brevibacillus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930941 – 3587Tyrocidine synthase 2Add BLAST3587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1007O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2042O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3075O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Large multienzyme complex of TycA, TycB and TycC.

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		54914.AV540_22695

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13587
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O30408

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini972 – 1047Carrier 1PROSITE-ProRule annotationAdd BLAST76
Domaini2007 – 2082Carrier 2PROSITE-ProRule annotationAdd BLAST76
Domaini3040 – 3114Carrier 3PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni466 – 1045Domain 1 (Proline-activating)Add BLAST580
Regioni1522 – 2081Domain 2 (Phenylalanine-activating)Add BLAST560
Regioni2540 – 3122Domain 3 (D-phenylalanine-activating)Add BLAST583
Regioni3017 – 3040DisorderedSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of three modules, including a C-terminal epimerization domain. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional), and N methylation (optional).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 3 hits
3.30.300.30, 3 hits
3.30.559.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 3 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00823, PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336, SSF47336, 3 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01733, AA-adenyl-dom, 3 hits
TIGR01720, NRPS-para261, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O30408-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVFSKEQVQ DMYALTPMQE GMLFHALLDQ EHNSHLVQMS ISLQGDLDVG 
        60         70         80         90        100
LFTDSLHVLV ERYDVFRTLF LYEKLKQPLQ VVLKQRPIPI EFYDLSACDE 
       110        120        130        140        150
SEKQLRYTQY KRADQERTFH LAKDPLMRVA LFQMSQHDYQ VIWSFHHILM 
       160        170        180        190        200
DGWCFSIIFD DLLAIYLSLQ NKTALSLEPV QPYSRFINWL EKQNKQAALN 
       210        220        230        240        250
YWSDYLEAYE QKTTLPKKEA AFAKAFQPTQ YRFSLNRTLT KQLGTIASQN 
       260        270        280        290        300
QVTLSTVIQT IWGVLLQKYN AAHDVLFGSV VSGRPTDIVG IDKMVGLFIN 
       310        320        330        340        350
TIPFRVQAKA GQTFSELLQA VHKRTLQSQP YEHVPLYDIQ TQSVLKQELI 
       360        370        380        390        400
DHLLVIENYP LVEALQKKAL NQQIGFTITA VEMFEPTNYD LTVMVMPKEE 
       410        420        430        440        450
LAFRFDYNAA LFDEQVVQKL AGHLQQIADC VANNSGVELC QIPLLTEAET 
       460        470        480        490        500
SQLLAKRTET AADYPAATMH ELFSRQAEKT PEQVAVVFAD QHLTYRELDE 
       510        520        530        540        550
KSNQLARFLR KKGIGTGSLV GTLLDRSLDM IVGILGVLKA GGAFVPIDPE 
       560        570        580        590        600
LPAERIAYML THSRVPLVVT QNHLRAKVTT PTETIDINTA VIGEESRAPI 
       610        620        630        640        650
ESLNQPHDLF YIIYTSGTTG QPKGVMLEHR NMANLMHFTF DQTNIAFHEK 
       660        670        680        690        700
VLQYTTCSFD VCYQEIFSTL LSGGQLYLIT NELRRHVEKL FAFIQEKQIS 
       710        720        730        740        750
ILSLPVSFLK FIFNEQDYAQ SFPRCVKHII TAGEQLVVTH ELQKYLRQHR 
       760        770        780        790        800
VFLHNHYGPS ETHVVTTCTM DPGQAIPELP PIGKPISNTG IYILDEGLQL 
       810        820        830        840        850
KPEGIVGELY ISGANVGRGY LHQPELTAEK FLDNPYQPGE RMYRTGDLAL 
       860        870        880        890        900
WLPDGQLEFL GRIDHQVKIR GHRIELGEIE SRLLNHPAIK EAVVIDRADE 
       910        920        930        940        950
TGGKFLCAYV VLQKALSDEE MRAYLAQALP EYMIPSFFVT LERIPVTPNG 
       960        970        980        990       1000
KTDRRALPKP EGSAKTKADY VAPTTELEQK LVAIWEQILG VSPIGIQDHF 
      1010       1020       1030       1040       1050
FTLGGHSLKA IQLISRIQKE CQADVPLRVL FEQPTIQALA AYVEGGEESA 
      1060       1070       1080       1090       1100
YLAIPQAEPQ AYYPVSSAQK RMLILNQLDP HSTVYNLPVA MILEGTLDKA 
      1110       1120       1130       1140       1150
RLEHAISNLV ARHESLRTSF HTINGEPVSR IHEQGHLPIV YLETAEEQVN 
      1160       1170       1180       1190       1200
EVILGFMQPF DLVTAPLCRV GLVKLAENRH VLIIDMHHII SDGVSSQLIL 
      1210       1220       1230       1240       1250
NDFSRLYQNK ALPEQRIHYK DFAVWEKAWT QTTDYQKQEK YWLDRFAGEI 
      1260       1270       1280       1290       1300
PVLNLPMDYP RPAVQSFEGE RYLFRTEKQL LESLQDVAQK TGTTLYMVLL 
      1310       1320       1330       1340       1350
AAYHVLLSKY SGQDDVMIGT VTAGRVHPDT ESMTGMFVNT LAMRNQSAPT 
      1360       1370       1380       1390       1400
KTFRQFLLEV KDNTLAAFEH GQYPFEELVE KLAIQRNRSR NPLFDTLFIL 
      1410       1420       1430       1440       1450
QNMDADLIEL DGLTVTPYVP EGEVAKFDLS LEASENQAGL SFCFEFCTKL 
      1460       1470       1480       1490       1500
FARETIERMS LHYLQILQAV SANTEQELAQ IEMLTAHEKQ ELLVHFNDTA 
      1510       1520       1530       1540       1550
ALYPAESTLS QLFEDQAQKT PEQTAVVFGD KRLTYRELNE RANQLAHTLR 
      1560       1570       1580       1590       1600
AKGVQAEQSV GIMAQRSLEM AIGIIAILKA GGAYVPIDPD YPNERIAYML 
      1610       1620       1630       1640       1650
EDCRRLVLTQ QQLAEKMTAN VECLYLDEEG SYSPQTENIE PIHTAADLAY 
      1660       1670       1680       1690       1700
IIYTSGTTGR PKGVMVEHRG IVNSVTWNRD EFALSVRDSG TLSLSFAFDA 
      1710       1720       1730       1740       1750
FALTFFTLIV SGSTVVLMPD HEAKDPIALR NLIAAWECSY VVFVPSMFQA 
      1760       1770       1780       1790       1800
ILECSTPADI RSIQAVMLGG EKLSPKLVQL CKAMHPQMSV MNAYGPTESS 
      1810       1820       1830       1840       1850
VMATYLRDTQ PDQPITIGRP IANTAIYIVD QHHQLLPVGV VGEICIGGHG 
      1860       1870       1880       1890       1900
LARGYWKKPE LTAEKFVANP AVPGERMYKT GDLGRWLHDG TIDFIGRVDD 
      1910       1920       1930       1940       1950
QIKVRGYRIE VGEIEAVLLA YDQTNEAIVV AYQDDRGDSY LAAYVTGKTA 
      1960       1970       1980       1990       2000
IEESELRAHL LRELPAYMVP TYLIQLDAFP LTPNGKVDRK ALPKPEGKPA 
      2010       2020       2030       2040       2050
TGAAYVAPAT EVEAKLVAIW ENALGISGVG VLDHFFELGG HSLKAMTVVA 
      2060       2070       2080       2090       2100
QVHREFQIDL LLKQFFAAPT IRDLARLIEH SEQAAGAAIQ PAEPQAYYPV 
      2110       2120       2130       2140       2150
SSAQQRMYLL HQLEGAGISY NTPGIIMLEG KLDREQLANA LQALVDRHDI 
      2160       2170       2180       2190       2200
LRTSFEMVGD ELVQKIHDRV AVNMEYVTAE EQQIDDLFHA FVRPFDLSVP 
      2210       2220       2230       2240       2250
PLLRMSLVKL ADERHLLLYD MHHIAADAAS ITILFDELAE LYQGRELPEM 
      2260       2270       2280       2290       2300
RIQYKDFAVW QKALHESDAF KQQEAYWLST FAGNITAVDV PTDFPRPAVK 
      2310       2320       2330       2340       2350
SFAGGQVTLS MDQELLSALH ELAAHTNTTL FMVLLAAYNV LLAKYAGQDD 
      2360       2370       2380       2390       2400
IIVGTPISGR SRAELAPVVG MFVHTLAIRN KPTAEKTFKQ FLQEVKQNAL 
      2410       2420       2430       2440       2450
DAFDHQDYPF ESLVEKLGIP RDPGRNPLFD TMFILQNDEL HAKTLDQLVY 
      2460       2470       2480       2490       2500
RPYESDSALD VAKFDLSFHL TERETDLFLR LEYCTKLFKQ QTVERMAHHF 
      2510       2520       2530       2540       2550
LQILRAVTAN PENELQEIEM LTAAEKQMLL VAFNDTHREY RADQTIQQLF 
      2560       2570       2580       2590       2600
EELAEKMPEH TALVFEEKRM SFRELNERAN QLAAVLREKG VGPAQIVALL 
      2610       2620       2630       2640       2650
VERSAEMVIA TLATLKAGGA FLPVDPDYPE ERIRYMLEDS QAKLVVTHAH 
      2660       2670       2680       2690       2700
LLHKVSSQSE VVDVDDPGSY ATQTDNLPCA NTPSDLAYII YTSGTTGKPK 
      2710       2720       2730       2740       2750
GVMLEHKGVA NLQAVFAHHL GVTPQDRAGH FASISFDASV WDMFGPLLSG 
      2760       2770       2780       2790       2800
ATLYVLSRDV INDFQRFAEY VRDNAITFLT LPPTYAIYLE PEQVPSLRTL 
      2810       2820       2830       2840       2850
ITAGSASSVA LVDKWKEKVT YVNGYGPTES TVCATLWKAK PDEPVETITI 
      2860       2870       2880       2890       2900
GKPIQNTKLY IVDDQLQLKA PGQMGELCIS GLSLARGYWN RPELTAEKFV 
      2910       2920       2930       2940       2950
DNPFVPGTKM YRTGDLARWL PDGTIEYLGR IDHQVKIRGH RVELGEVESV 
      2960       2970       2980       2990       3000
LLRYDTVKEA AAITHEDDRG QAYLCAYYVA EGEATPAQLR AYMENELPNY 
      3010       3020       3030       3040       3050
MVPAFFIQLE KMPLTPNDKI DRKALPKPNQ EENRTEQYAA PQTELEQLLA 
      3060       3070       3080       3090       3100
GIWADVLGIK QVGTQDNFFE LGGDSIKAIQ VSTRLNASGW TLAMKELFQY 
      3110       3120       3130       3140       3150
PTIEEAALRV IPNSRESEQG VVEGEIALTP IQKWFFANNF TDRHHWNQAV 
      3160       3170       3180       3190       3200
MLFREDGFDE GLVRQAFQQI VEHHDALRMV YKQEDGAIKQ INRGLTDERF 
      3210       3220       3230       3240       3250
RFYSYDLKNH ANSEARILEL SDQIQSSIDL EHGPLVHVAL FATKDGDHLL 
      3260       3270       3280       3290       3300
VAIHHLVVDG VSWRILFEDF SSAYSQALHQ QEIVLPKKTD SFKDWAAQLQ 
      3310       3320       3330       3340       3350
KYADSDELLR EVAYWHNLET TTTTAALPTD FVTADRKQKH TRTLSFALTV 
      3360       3370       3380       3390       3400
PQTENLLRHV HHAYHTEMND LLLTALGLAV KDWAHTNGVV INLEGHGRED 
      3410       3420       3430       3440       3450
IQNEMNVTRT IGWFTSQYPV VLDMEKAEDL PYQIKQTKEN LRRIPKKGIG 
      3460       3470       3480       3490       3500
YEILRTLTTS QLQPPLAFTL RPEISFNYLG QFESDGKTGG FTFSPLGTGQ 
      3510       3520       3530       3540       3550
LFSPESERVF LLDISAMIED GELRISVGYS RLQYEEKTIA SLADSYRKHL 
      3560       3570       3580 
LGIIEHCMAK EEGEYTPSDL GDEELSMEEL ENILEWI
Length:3,587
Mass (Da):404,817
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i322B8471BBB28B47
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF004835 Genomic DNA Translation: AAC45929.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ag:AAC45929

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004835 Genomic DNA Translation: AAC45929.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

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Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6TA8X-ray2.40A/B3113-3587[»]
SMRiO30408
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi54914.AV540_22695

Genome annotation databases

KEGGiag:AAC45929

Enzyme and pathway databases

UniPathwayiUPA00180
SABIO-RKiO30408

Family and domain databases

Gene3Di1.10.1200.10, 3 hits
3.30.300.30, 3 hits
3.30.559.10, 4 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 3 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 3 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 3 hits
SUPFAMiSSF47336, SSF47336, 3 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 3 hits
TIGR01720, NRPS-para261, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYCB_BREPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O30408
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: February 23, 2022
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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