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Protein

RIO-type serine/threonine-protein kinase Rio2

Gene

rio2

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+, Mn2+Note: Mg2+. Mn2+ is seen in the crystal structure; there are 2 Mn2+ ions in the ATP-bound crystal and 1 Mn2+ in the ADP-bound crystal.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi103Magnesium 11 Publication1
Binding sitei120ATP1 Publication1
Binding sitei126ATPCombined sources1 Publication1
Active sitei218Proton acceptorPROSITE-ProRule annotation1
Binding sitei222ATP; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi223Magnesium 21 Publication1
Binding sitei223ATPCombined sources1 Publication1
Metal bindingi235Magnesium 11 Publication1
Metal bindingi235Magnesium 21 Publication1
Binding sitei235ATPCombined sources2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi98 – 106ATPPROSITE-ProRule annotation9
Nucleotide bindingi180 – 186ATPCombined sources2 Publications7

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 414

Names & Taxonomyi

Protein namesi
Recommended name:
RIO-type serine/threonine-protein kinase Rio2 (EC:2.7.11.1)
Short name:
AfRio2
Gene namesi
Name:rio2
Ordered Locus Names:AF_2426
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003473341 – 282RIO-type serine/threonine-protein kinase Rio2Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128Phosphoserine; by autocatalysis1 Publication1

Post-translational modificationi

Autophosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO30245

PTM databases

iPTMnetiO30245

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi224325.AF2426

Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO30245
SMRiO30245
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO30245

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 282Protein kinasePROSITE-ProRule annotationAdd BLAST191

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01181 Archaea
COG0478 LUCA
KOiK07179
OMAiFITHDER
OrthoDBiPOG093Z07MT

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR015285 RIO2_wHTH_N
IPR000687 RIO_kinase
IPR008266 Tyr_kinase_AS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF09202 Rio2_N, 1 hit
SMARTiView protein in SMART
SM00090 RIO, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF56112 SSF56112, 1 hit

Sequencei

Sequence statusi: Complete.

O30245-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIAELYGKM GKHSWRIMDA IFKNLWDYEY VPLQLISSHA RIGEEKARNI
60 70 80 90 100
LKYLSDLRVV QNRQKDYEGS TFTFIGLSLY SLHRLVRSGK VDAIGKLMGE
110 120 130 140 150
GKESAVFNCY SEKFGECVVK FHKVGHTSFK KVKEKRDYGD LHFSVLAIRS
160 170 180 190 200
ARNEFRALQK LQGLAVPKVY AWEGNAVLME LIDAKELYRV RVENPDEVLD
210 220 230 240 250
MILEEVAKFY HRGIVHGDLS QYNVLVSEEG IWIIDFPQSV EVGEEGWREI
260 270 280
LERDVRNIIT YFSRTYRTEK DINSAIDRIL QE
Length:282
Mass (Da):32,809
Last modified:January 1, 1998 - v1
Checksum:i7DE69AF0EF8DB24D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB91236.1
PIRiC69553
RefSeqiWP_010879913.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB91236; AAB91236; AF_2426
GeneIDi24796150
KEGGiafu:AF_2426

Similar proteinsi

Entry informationi

Entry nameiRIO2_ARCFU
AccessioniPrimary (citable) accession number: O30245
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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