UniProtKB - O29912 (PCNA_ARCFU)
Protein
DNA polymerase sliding clamp
Gene
pcn
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Functioni
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA polymerase processivity factor activity Source: UniProtKB-UniRule
GO - Biological processi
- DNA replication Source: UniProtKB-KW
- regulation of DNA replication Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA replication |
Enzyme and pathway databases
BRENDAi | 3.1.26.4, 414 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA polymerase sliding clampUniRule annotationAlternative name(s): Proliferating cell nuclear antigen homologUniRule annotation Short name: PCNAUniRule annotation |
Gene namesi | Name:pcnUniRule annotation Ordered Locus Names:AF_0335 |
Organismi | Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) |
Taxonomic identifieri | 224325 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149192 | 1 – 245 | DNA polymerase sliding clampAdd BLAST | 245 |
Interactioni
Subunit structurei
Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
UniRule annotationProtein-protein interaction databases
STRINGi | 224325.AF_0335 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O29912 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O29912 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PCNA family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG00488, Archaea |
HOGENOMi | CLU_043978_1_1_2 |
OMAi | EMKLINM |
OrthoDBi | 70433at2157 |
Family and domain databases
HAMAPi | MF_00317, DNApol_clamp_arch, 1 hit |
IDEALi | IID90026 |
InterProi | View protein in InterPro IPR000730, Pr_cel_nuc_antig IPR022649, Pr_cel_nuc_antig_C IPR022659, Pr_cel_nuc_antig_CS IPR022648, Pr_cel_nuc_antig_N |
PANTHERi | PTHR11352:SF0, PTHR11352:SF0, 1 hit |
Pfami | View protein in Pfam PF02747, PCNA_C, 1 hit PF00705, PCNA_N, 1 hit |
PRINTSi | PR00339, PCNACYCLIN |
PROSITEi | View protein in PROSITE PS01251, PCNA_1, 1 hit |
i Sequence
Sequence statusi: Complete.
O29912-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIDVIMTGEL LKTVTRAIVA LVSEARIHFL EKGLHSRAVD PANVAMVIVD
60 70 80 90 100
IPKDSFEVYN IDEEKTIGVD MDRIFDISKS ISTKDLVELI VEDESTLKVK
110 120 130 140 150
FGSVEYKVAL IDPSAIRKEP RIPELELPAK IVMDAGEFKK AIAAADKISD
160 170 180 190 200
QVIFRSDKEG FRIEAKGDVD SIVFHMTETE LIEFNGGEAR SMFSVDYLKE
210 220 230 240
FCKVAGSGDL LTIHLGTNYP VRLVFELVGG RAKVEYILAP RIESE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000782 Genomic DNA Translation: AAB90899.1 |
PIRi | G69291 |
RefSeqi | WP_010877842.1, NC_000917.1 |
Genome annotation databases
EnsemblBacteriai | AAB90899; AAB90899; AF_0335 |
GeneIDi | 24793874 |
KEGGi | afu:AF_0335 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000782 Genomic DNA Translation: AAB90899.1 |
PIRi | G69291 |
RefSeqi | WP_010877842.1, NC_000917.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RWZ | X-ray | 1.80 | A | 1-245 | [»] | |
1RXM | X-ray | 2.80 | A | 1-245 | [»] | |
1RXZ | X-ray | 2.00 | A | 1-245 | [»] | |
3P83 | X-ray | 3.05 | A/B/C | 1-245 | [»] | |
SMRi | O29912 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 224325.AF_0335 |
Genome annotation databases
EnsemblBacteriai | AAB90899; AAB90899; AF_0335 |
GeneIDi | 24793874 |
KEGGi | afu:AF_0335 |
Phylogenomic databases
eggNOGi | arCOG00488, Archaea |
HOGENOMi | CLU_043978_1_1_2 |
OMAi | EMKLINM |
OrthoDBi | 70433at2157 |
Enzyme and pathway databases
BRENDAi | 3.1.26.4, 414 |
Miscellaneous databases
EvolutionaryTracei | O29912 |
Family and domain databases
HAMAPi | MF_00317, DNApol_clamp_arch, 1 hit |
IDEALi | IID90026 |
InterProi | View protein in InterPro IPR000730, Pr_cel_nuc_antig IPR022649, Pr_cel_nuc_antig_C IPR022659, Pr_cel_nuc_antig_CS IPR022648, Pr_cel_nuc_antig_N |
PANTHERi | PTHR11352:SF0, PTHR11352:SF0, 1 hit |
Pfami | View protein in Pfam PF02747, PCNA_C, 1 hit PF00705, PCNA_N, 1 hit |
PRINTSi | PR00339, PCNACYCLIN |
PROSITEi | View protein in PROSITE PS01251, PCNA_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCNA_ARCFU | |
Accessioni | O29912Primary (citable) accession number: O29912 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families