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UniProtKB - O29844 (GGGPS_ARCFU)
Protein
Geranylgeranylglyceryl phosphate synthase
Gene
AF_0403
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Status
Functioni
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. To a much lesser extent, is also able to use heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) as the prenyl donor.
4 PublicationsCatalytic activityi
- (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphateUniRule annotation4 PublicationsEC:2.5.1.41UniRule annotation4 Publications
Cofactori
Mg2+UniRule annotation
: glycerophospholipid metabolism Pathwayi
This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation1 PublicationView all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 11 | Glycerol-1-phosphateUniRule annotationCombined sources1 Publication | 1 | |
Metal bindingi | 13 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 39 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 195 | Glycerol-1-phosphate; via amide nitrogenUniRule annotationCombined sources1 Publication | 1 |
GO - Molecular functioni
- magnesium ion binding Source: UniProtKB-UniRule
- phosphoglycerol geranylgeranyltransferase activity Source: UniProtKB-UniRule
- polyprenyltransferase activity Source: InterPro
GO - Biological processi
- glycerophospholipid biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00940 |
Names & Taxonomyi
Protein namesi | Recommended name: Geranylgeranylglyceryl phosphate synthaseUniRule annotationCurated (EC:2.5.1.41UniRule annotation4 Publications)Short name: AfGGGPS1 Publication Short name: GGGP synthase1 PublicationUniRule annotation Short name: GGGPSUniRule annotationCurated Alternative name(s): (S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotationCurated Phosphoglycerol geranylgeranyltransferaseUniRule annotationCurated |
Gene namesi | Ordered Locus Names:AF_0403 |
Organismi | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) |
Taxonomic identifieri | 224325 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 99 | W → A: Increased efficiency with HepPP as substrate, wich becomes similar to that of B.subtilis PcrB. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000138728 | 1 – 231 | Geranylgeranylglyceryl phosphate synthaseAdd BLAST | 231 |
Interactioni
Subunit structurei
Homodimer.
3 PublicationsProtein-protein interaction databases
STRINGi | 224325.AF_0403 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | O29844 |
SMRi | O29844 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O29844 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 165 – 170 | Glycerol-1-phosphate bindingUniRule annotationCombined sources1 Publication | 6 | |
Regioni | 215 – 216 | Glycerol-1-phosphate bindingUniRule annotationCombined sources1 Publication | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | arCOG01085, Archaea |
HOGENOMi | CLU_095211_0_0_2 |
OMAi | TGAHKEW |
OrthoDBi | 74340at2157 |
PhylomeDBi | O29844 |
Family and domain databases
CDDi | cd02812, PcrB_like, 1 hit |
Gene3Di | 3.20.20.390, 1 hit |
HAMAPi | MF_00112, GGGP_HepGP_synthase, 1 hit |
InterProi | View protein in InterPro IPR039074, GGGP/HepGP_synthase_I IPR038597, GGGP/HepGP_synthase_sf IPR008205, GGGP_HepGP_synthase IPR026438, GGGP_synthase_archaea |
PANTHERi | PTHR40029, PTHR40029, 1 hit |
Pfami | View protein in Pfam PF01884, PcrB, 1 hit |
TIGRFAMsi | TIGR01768, GGGP-family, 1 hit TIGR04146, GGGPS_Afulg, 1 hit |
i Sequence
Sequence statusi: Complete.
O29844-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRWRKWRHIT KLDPDRTNTD EIIKAVADSG TDAVMISGTQ NVTYEKARTL
60 70 80 90 100
IEKVSQYGLP IVVEPSDPSN VVYDVDYLFV PTVLNSADGD WITGKHAQWV
110 120 130 140 150
RMHYENLQKF TEIIESEFIQ IEGYIVLNPD SAVARVTKAL CNIDKELAAS
160 170 180 190 200
YALVGEKLFN LPIIYIEYSG TYGNPELVAE VKKVLDKARL FYGGGIDSRE
210 220 230
KAREMLRYAD TIIVGNVIYE KGIDAFLETL P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000782 Genomic DNA Translation: AAB90827.1 |
PIRi | C69300 |
RefSeqi | WP_010877910.1, NC_000917.1 |
Genome annotation databases
EnsemblBacteriai | AAB90827; AAB90827; AF_0403 |
GeneIDi | 24793941 |
KEGGi | afu:AF_0403 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000782 Genomic DNA Translation: AAB90827.1 |
PIRi | C69300 |
RefSeqi | WP_010877910.1, NC_000917.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2F6U | X-ray | 1.55 | A/B | 1-231 | [»] | |
2F6X | X-ray | 2.00 | A/B | 1-231 | [»] | |
AlphaFoldDBi | O29844 | |||||
SMRi | O29844 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 224325.AF_0403 |
Genome annotation databases
EnsemblBacteriai | AAB90827; AAB90827; AF_0403 |
GeneIDi | 24793941 |
KEGGi | afu:AF_0403 |
Phylogenomic databases
eggNOGi | arCOG01085, Archaea |
HOGENOMi | CLU_095211_0_0_2 |
OMAi | TGAHKEW |
OrthoDBi | 74340at2157 |
PhylomeDBi | O29844 |
Enzyme and pathway databases
UniPathwayi | UPA00940 |
Miscellaneous databases
EvolutionaryTracei | O29844 |
Family and domain databases
CDDi | cd02812, PcrB_like, 1 hit |
Gene3Di | 3.20.20.390, 1 hit |
HAMAPi | MF_00112, GGGP_HepGP_synthase, 1 hit |
InterProi | View protein in InterPro IPR039074, GGGP/HepGP_synthase_I IPR038597, GGGP/HepGP_synthase_sf IPR008205, GGGP_HepGP_synthase IPR026438, GGGP_synthase_archaea |
PANTHERi | PTHR40029, PTHR40029, 1 hit |
Pfami | View protein in Pfam PF01884, PcrB, 1 hit |
TIGRFAMsi | TIGR01768, GGGP-family, 1 hit TIGR04146, GGGPS_Afulg, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GGGPS_ARCFU | |
Accessioni | O29844Primary (citable) accession number: O29844 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families