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Entry version 147 (12 Aug 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Probable copper-exporting P-type ATPase

Gene

copA

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably involved in copper and silver export.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by Cu+ and Ag+ and inhibited by vanadate. Activated by CopZ in its Cu+-bound form.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Shows higher affinity for Cu+ compared with Ag+.
  1. KM=0.25 mM for ATP2 Publications
  1. Vmax=14.9 µmol/h/mg enzyme with Ag+ as substrate2 Publications
  2. Vmax=3.7 µmol/h/mg enzyme with Cu+ as substrate2 Publications

pH dependencei

Optimum pH is 6.1-6.5.2 Publications

Temperature dependencei

Optimum temperature is 75 degrees Celsius.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi27CopperPROSITE-ProRule annotation1
Metal bindingi30CopperPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4244-aspartylphosphate intermediateBy similarity1
Metal bindingi618MagnesiumPROSITE-ProRule annotation1
Metal bindingi622MagnesiumPROSITE-ProRule annotation1
Metal bindingi751CopperPROSITE-ProRule annotation1
Metal bindingi754CopperPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi457 – 462ATPSequence analysis6
Nucleotide bindingi490 – 501ATPSequence analysisAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.3.54, 414

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O29777

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.5.7, the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable copper-exporting P-type ATPase (EC:7.2.2.81 Publication)
Alternative name(s):
Copper-exporting P-type ATPase A
Cu(+)-exporting ATPase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:copA
Synonyms:pacS
Ordered Locus Names:AF_0473
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224325 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002199 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 101CytoplasmicSequence analysisAdd BLAST101
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 128ExtracellularSequence analysis6
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 159CytoplasmicSequence analysis10
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 186ExtracellularSequence analysis6
Transmembranei187 – 204HelicalSequence analysisAdd BLAST18
Topological domaini205 – 339CytoplasmicSequence analysisAdd BLAST135
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 364ExtracellularSequence analysis4
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 680CytoplasmicSequence analysisAdd BLAST295
Transmembranei681 – 701HelicalSequence analysisAdd BLAST21
Topological domaini702 – 704ExtracellularSequence analysis3
Transmembranei705 – 725HelicalSequence analysisAdd BLAST21
Topological domaini726 – 804CytoplasmicSequence analysisAdd BLAST79

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27C → A: Reduction in ATPase activity; when associated with A-30. 2 Publications1
Mutagenesisi30C → A: Reduction in ATPase activity; when associated with A-27. 2 Publications1
Mutagenesisi380C → A: Abolishes activity. 2 Publications1
Mutagenesisi382C → A or S: Abolishes activity. 2 Publications1
Mutagenesisi751C → A: No effect on ATPase activity; when associated with A-754. Reduction in ATPase activity; when associated with A-27; A-30 and A-754. 2 Publications1
Mutagenesisi754C → A: No effect on ATPase activity, when associated with A-751. Reduction in ATPase activity; when associated with A-27; A-30 and A-751. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003506011 – 804Probable copper-exporting P-type ATPaseAdd BLAST804

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O29777

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CopZ probably in the CopZ Cu+-bound form.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O29777
With#Exp.IntAct
itself2EBI-9016967,EBI-9016967

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-46021N

STRING: functional protein association networks

More...
STRINGi
224325.AF_0473

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1804
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O29777

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O29777

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 83HMA 1PROSITE-ProRule annotationAdd BLAST67
Domaini741 – 802HMA 2PROSITE-ProRule annotationAdd BLAST62

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG01576, Archaea
arCOG02763, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001771_0_3_2

KEGG Orthology (KO)

More...
KOi
K17686

Identification of Orthologs from Complete Genome Data

More...
OMAi
HWMLPAW

Database of Orthologous Groups

More...
OrthoDBi
21472at2157

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00371, HMA, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR017969, Heavy-metal-associated_CS
IPR006122, HMA_Cu_ion-bd
IPR006121, HMA_dom
IPR036163, HMA_dom_sf
IPR027256, P-typ_ATPase_IB
IPR001757, P_typ_ATPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00403, HMA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55008, SSF55008, 2 hits
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01525, ATPase-IB_hvy, 1 hit
TIGR01494, ATPase_P-type, 1 hit
TIGR00003, TIGR00003, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit
PS01047, HMA_1, 1 hit
PS50846, HMA_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O29777-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKDTYISSA SKTPPMERTV RVTGMTCAMC VKSIETAVGS LEGVEEVRVN
60 70 80 90 100
LATETAFIRF DEKRIDFETI KRVIEDLGYG VVDEQAAVSA EVEHLSRMKR
110 120 130 140 150
KLYVAAFAGV LLLFLAHFIS LPYEDFVQLL IALPAIFYSG SSIFKAAFSA
160 170 180 190 200
LRRRTLNMDV MYSMGVGAAF LASVLSTAGV LPREYSFYET SVLLLAFLLL
210 220 230 240 250
GRTLEARAKS RTGEAIKKLV GLQAKTAVVI RDGKEIAVPV EEVAVGDIVI
260 270 280 290 300
VRPGEKIPVD GVVVEGESYV DESMISGEPV PVLKSKGDEV FGATINNTGV
310 320 330 340 350
LKIRATRVGG ETLLAQIVKL VEDAMGSKPP IQRLADKVVA YFIPTVLLVA
360 370 380 390 400
ISAFIYWYFI AHAPLLFAFT TLIAVLVVAC PCAFGLATPT ALTVGMGKGA
410 420 430 440 450
ELGILIKNAD ALEVAEKVTA VIFDKTGTLT KGKPEVTDLV PLNGDERELL
460 470 480 490 500
RLAAIAERRS EHPIAEAIVK KALEHGIELG EPEKVEVIAG EGVVADGILV
510 520 530 540 550
GNKRLMEDFG VAVSNEVELA LEKLEREAKT AVIVARNGRV EGIIAVSDTL
560 570 580 590 600
KESAKPAVQE LKRMGIKVGM ITGDNWRSAE AISRELNLDL VIAEVLPHQK
610 620 630 640 650
SEEVKKLQAK EVVAFVGDGI NDAPALAQAD LGIAVGSGSD VAVESGDIVL
660 670 680 690 700
IRDDLRDVVA AIQLSRKTMS KIKQNIFWAL IYNVILIPAA AGLLYPIFGV
710 720 730 740 750
VFRPEFAGLA MAMSSVSVVA NSLLLRNYVP PIRRGGDSVE KIVLELSGLS
760 770 780 790 800
CHHCVARVKK ALEEAGAKVE KVDLNEAVVA GNKEDVDKYI KAVEAAGYQA

KLRS
Length:804
Mass (Da):86,432
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i610EB948C1D6B16F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB90763.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A69309

NCBI Reference Sequences

More...
RefSeqi
WP_010877980.1, NC_000917.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAB90763; AAB90763; AF_0473

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24794013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afu:AF_0473

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB90763.1
PIRiA69309
RefSeqiWP_010877980.1, NC_000917.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B8EX-ray2.30A/B/C407-671[»]
2HC8X-ray1.65A214-325[»]
2VOYelectron microscopy18.00F214-326[»]
I410-663[»]
J432-549[»]
3A1CX-ray1.85A/B398-673[»]
3A1DX-ray1.85A/B398-673[»]
3A1EX-ray1.95A/B398-673[»]
3FRYX-ray2.00A/B736-804[»]
3J08electron microscopy-A/B93-737[»]
3J09electron microscopy-A/B15-737[»]
SMRiO29777
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-46021N
STRINGi224325.AF_0473

Protein family/group databases

TCDBi3.A.3.5.7, the p-type atpase (p-atpase) superfamily

Proteomic databases

PRIDEiO29777

Genome annotation databases

EnsemblBacteriaiAAB90763; AAB90763; AF_0473
GeneIDi24794013
KEGGiafu:AF_0473

Phylogenomic databases

eggNOGiarCOG01576, Archaea
arCOG02763, Archaea
HOGENOMiCLU_001771_0_3_2
KOiK17686
OMAiHWMLPAW
OrthoDBi21472at2157

Enzyme and pathway databases

BRENDAi3.6.3.54, 414
SABIO-RKiO29777

Miscellaneous databases

EvolutionaryTraceiO29777

Family and domain databases

CDDicd00371, HMA, 2 hits
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR017969, Heavy-metal-associated_CS
IPR006122, HMA_Cu_ion-bd
IPR006121, HMA_dom
IPR036163, HMA_dom_sf
IPR027256, P-typ_ATPase_IB
IPR001757, P_typ_ATPase
PfamiView protein in Pfam
PF00403, HMA, 1 hit
SUPFAMiSSF55008, SSF55008, 2 hits
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01525, ATPase-IB_hvy, 1 hit
TIGR01494, ATPase_P-type, 1 hit
TIGR00003, TIGR00003, 1 hit
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit
PS01047, HMA_1, 1 hit
PS50846, HMA_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOPA_ARCFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O29777
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: January 1, 1998
Last modified: August 12, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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