We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - O29758 (RRP4_ARCFU)
Protein
Exosome complex component Rrp4
Gene
rrp4
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Status
Functioni
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome (Probable).
2 PublicationsGO - Molecular functioni
- poly(A) binding Source: InterPro
GO - Biological processi
- RNA catabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Exosome complex component Rrp4UniRule annotation |
Gene namesi | Name:rrp4UniRule annotation Ordered Locus Names:AF_0492 |
Organismi | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) |
Taxonomic identifieri | 224325 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
- exosome (RNase complex) Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, ExosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050145 | 1 – 223 | Exosome complex component Rrp4Add BLAST | 223 |
Interactioni
Subunit structurei
Component of the archaeal exosome complex.
Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
UniRule annotation2 PublicationsProtein-protein interaction databases
STRINGi | 224325.AF_0492 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O29758 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O29758 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 127 | S1 motifUniRule annotationAdd BLAST | 70 | |
Domaini | 135 – 193 | KHUniRule annotationAdd BLAST | 59 |
Domaini
Contains an N-terminal domain that mediates interactions with the hexameric ring, a central S1 domain and a C-terminal KH domain.1 Publication
Sequence similaritiesi
Belongs to the RRP4 family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG00678, Archaea |
HOGENOMi | CLU_071769_0_0_2 |
OMAi | GPYIPEV |
OrthoDBi | 93052at2157 |
PhylomeDBi | O29758 |
Family and domain databases
Gene3Di | 3.30.1370.10, 1 hit |
HAMAPi | MF_00623, Exosome_Rrp4, 1 hit |
InterProi | View protein in InterPro IPR026699, Exosome_RNA_bind1/RRP40/RRP4 IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR012340, NA-bd_OB-fold IPR023474, Rrp4 IPR022967, S1_dom IPR003029, S1_domain |
PANTHERi | PTHR21321, PTHR21321, 1 hit |
Pfami | View protein in Pfam PF15985, KH_6, 1 hit PF00575, S1, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 1 hit SM00316, S1, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit SSF54791, SSF54791, 1 hit |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 1 hit PS50126, S1, 1 hit |
i Sequence
Sequence statusi: Complete.
O29758-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKIVLPGDL LSTNPRAAGY GTYVEGGKVY AKIIGLFDQT ETHVRVIPLK
60 70 80 90 100
GRYTPSVGDV VIGIIREVAA NGWAVDIYSP YQAFLPVSEN PEMKPNKKPN
110 120 130 140 150
EVLDIGDAII AKVLNIDPKM KVTLTMKDRI CRPIRFGRIV AINPARVPRV
160 170 180 190 200
IGKKGSMIKL LKSELDVQIV VGQNGLIWVN GDRRKVSIAE EAIYLIEQEA
210 220
HTEGLTDRVA EFIKRRKADV GIQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000782 Genomic DNA Translation: AAB90745.1 |
PIRi | D69311 |
RefSeqi | WP_010877999.1, NC_000917.1 |
Genome annotation databases
EnsemblBacteriai | AAB90745; AAB90745; AF_0492 |
GeneIDi | 24794032 |
KEGGi | afu:AF_0492 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000782 Genomic DNA Translation: AAB90745.1 |
PIRi | D69311 |
RefSeqi | WP_010877999.1, NC_000917.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2BA0 | X-ray | 2.70 | A/B/C | 1-223 | [»] | |
SMRi | O29758 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 224325.AF_0492 |
Genome annotation databases
EnsemblBacteriai | AAB90745; AAB90745; AF_0492 |
GeneIDi | 24794032 |
KEGGi | afu:AF_0492 |
Phylogenomic databases
eggNOGi | arCOG00678, Archaea |
HOGENOMi | CLU_071769_0_0_2 |
OMAi | GPYIPEV |
OrthoDBi | 93052at2157 |
PhylomeDBi | O29758 |
Miscellaneous databases
EvolutionaryTracei | O29758 |
Family and domain databases
Gene3Di | 3.30.1370.10, 1 hit |
HAMAPi | MF_00623, Exosome_Rrp4, 1 hit |
InterProi | View protein in InterPro IPR026699, Exosome_RNA_bind1/RRP40/RRP4 IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR012340, NA-bd_OB-fold IPR023474, Rrp4 IPR022967, S1_dom IPR003029, S1_domain |
PANTHERi | PTHR21321, PTHR21321, 1 hit |
Pfami | View protein in Pfam PF15985, KH_6, 1 hit PF00575, S1, 1 hit |
SMARTi | View protein in SMART SM00322, KH, 1 hit SM00316, S1, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit SSF54791, SSF54791, 1 hit |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 1 hit PS50126, S1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RRP4_ARCFU | |
Accessioni | O29758Primary (citable) accession number: O29758 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 25, 2003 |
Last sequence update: | January 1, 1998 | |
Last modified: | September 29, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families