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Entry version 111 (18 Sep 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Acetate--CoA ligase [ADP-forming] I

Gene

AF_1211

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can use other substrates such as propionyl-CoA and butyryl-CoA, but not phenylacetyl-CoA. Seems to be involved primarily in the conversion of acetyl-CoA to acetate. Participates in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity requires divalent metal cations.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 95 sec(-1) for acetyl-CoA. kcat is 70 sec(-1) for ADP. kcat is 58 sec(-1) for phosphate. kcat is 138 sec(-1) for acetate. kcat is 11.5 sec(-1) for phenylacetate. kcat is 150 sec(-1) for ATP. kcat is 110 sec(-1) for CoA.1 Publication
  1. KM=10 µM for acetyl-CoA1 Publication
  2. KM=7 µM for ADP1 Publication
  3. KM=110 µM for phosphate1 Publication
  4. KM=340 µM for acetate1 Publication
  5. KM=100 µM for phenylacetate1 Publication
  6. KM=133 µM for ATP1 Publication
  7. KM=27 µM for CoA1 Publication

    pH dependencei

    Optimum pH is 7.0.1 Publication

    Temperature dependencei

    Optimum temperature is 77 degrees Celsius.1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi503 – 514ATPPROSITE-ProRule annotationAdd BLAST12

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLigase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    AFUL224325:G1G17-1245-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    6.2.1.B11 414

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Acetate--CoA ligase [ADP-forming] ICurated (EC:6.2.1.131 Publication)
    Alternative name(s):
    ADP-forming acetyl coenzyme A synthetase ICurated
    Short name:
    ACS ICurated
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Ordered Locus Names:AF_1211Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224325 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002199 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004305181 – 685Acetate--CoA ligase [ADP-forming] IAdd BLAST685

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    224325.AF_1211

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O29057

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini477 – 513ATP-graspPROSITE-ProRule annotationAdd BLAST37

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    In the N-terminal section; belongs to the acetate CoA ligase alpha subunit family.Curated
    In the C-terminal section; belongs to the acetate CoA ligase beta subunit family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    arCOG01340 Archaea
    COG1042 LUCA

    KEGG Orthology (KO)

    More...
    KOi
    K01905
    K22224

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    CVPPIFI

    Database of Orthologous Groups

    More...
    OrthoDBi
    2789at2157

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.1490.20, 1 hit
    3.40.50.261, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR014089 AcCoA-synth-alpha
    IPR011761 ATP-grasp
    IPR013815 ATP_grasp_subdomain_1
    IPR003781 CoA-bd
    IPR036291 NAD(P)-bd_dom_sf
    IPR032875 Succ_CoA_lig_flav_dom
    IPR016102 Succinyl-CoA_synth-like

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13380 CoA_binding_2, 1 hit
    PF13607 Succ_CoA_lig, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00881 CoA_binding, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51735 SSF51735, 1 hit
    SSF52210 SSF52210, 2 hits

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02717 AcCoA-syn-alpha, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50975 ATP_GRASP, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    O29057-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MERLFYPKVV AVIGASPQEG KVGNTIMKNL RNFSGTVYAV NPKYREILGF
    60 70 80 90 100
    PCYPSVLKIP ENVDLAIIVV PAKLVPKAVE ECGRKDVEGA VVISAGFKEA
    110 120 130 140 150
    GIEGAKLERE LVEVAERYGV KLVGPNCLGM INTEIAMNAT FSRVAPEKGR
    160 170 180 190 200
    IAFLSQSGAF ILAVLEWSKR NGVGFSKVVS LGNKAMLDES DFLEYLAKDD
    210 220 230 240 250
    STDVILIYME GVEDGRKFMR VAKSVARRKP VVVMKAGKSQ SGAKAASSHT
    260 270 280 290 300
    GSLAGSYEAY RAAFRQSGVI EASSVEELFD FALLLLKYRK AGNLAILTNS
    310 320 330 340 350
    GGPGVMAADA CDQFGVPLAN FNFETIRKLK EFLPAESNFY NPVDILGDAS
    360 370 380 390 400
    AERFSRSLQI LSEDENVDIV LTILTPTAQM DFLKAAESVV GKNAVCCFMG
    410 420 430 440 450
    GESVDESERI LRSSGIPNFF DPVRAVRAIS VLGRYSKISA KERVKEDLDV
    460 470 480 490 500
    SVEREKAEEI IEKLLESGGR VVGAEGLPVL EAYGIEVAPY GIARNVDEAR
    510 520 530 540 550
    DIAESIGYPV VLKVVSPDVV HKSDVGGVKL NVGENDLEKA FFEILSNVEG
    560 570 580 590 600
    RMPKARIEGV LVQKMVDGGK ELIVGMKRDP QFGPMIMFGM GGVYVEVLKD
    610 620 630 640 650
    VSFRIAPITR REAHEMVREV KAYRILRGLR GEKPADIDAI ADLLLRVSKL
    660 670 680
    SLDHPEVLEM DLNPVKVFES GYAVVDFRMV LGEEV
    Length:685
    Mass (Da):74,698
    Last modified:January 1, 1998 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFC4A6D8FE39942F
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AE000782 Genomic DNA Translation: AAB90033.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    B69401

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_010878706.1, NC_000917.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAB90033; AAB90033; AF_1211

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1484435

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    afu:AF_1211

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AE000782 Genomic DNA Translation: AAB90033.1
    PIRiB69401
    RefSeqiWP_010878706.1, NC_000917.1

    3D structure databases

    SMRiO29057
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi224325.AF_1211

    Genome annotation databases

    EnsemblBacteriaiAAB90033; AAB90033; AF_1211
    GeneIDi1484435
    KEGGiafu:AF_1211

    Phylogenomic databases

    eggNOGiarCOG01340 Archaea
    COG1042 LUCA
    KOiK01905
    K22224
    OMAiCVPPIFI
    OrthoDBi2789at2157

    Enzyme and pathway databases

    BioCyciAFUL224325:G1G17-1245-MONOMER
    BRENDAi6.2.1.B11 414

    Family and domain databases

    Gene3Di3.30.1490.20, 1 hit
    3.40.50.261, 2 hits
    InterProiView protein in InterPro
    IPR014089 AcCoA-synth-alpha
    IPR011761 ATP-grasp
    IPR013815 ATP_grasp_subdomain_1
    IPR003781 CoA-bd
    IPR036291 NAD(P)-bd_dom_sf
    IPR032875 Succ_CoA_lig_flav_dom
    IPR016102 Succinyl-CoA_synth-like
    PfamiView protein in Pfam
    PF13380 CoA_binding_2, 1 hit
    PF13607 Succ_CoA_lig, 1 hit
    SMARTiView protein in SMART
    SM00881 CoA_binding, 1 hit
    SUPFAMiSSF51735 SSF51735, 1 hit
    SSF52210 SSF52210, 2 hits
    TIGRFAMsiTIGR02717 AcCoA-syn-alpha, 1 hit
    PROSITEiView protein in PROSITE
    PS50975 ATP_GRASP, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACD1_ARCFU
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O29057
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 29, 2014
    Last sequence update: January 1, 1998
    Last modified: September 18, 2019
    This is version 111 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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