thsB

Functionⁱ

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.By similarity

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein folding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thermosome subunit beta Alternative name(s): Chaperonin subunit beta Thermosome subunit 2
Gene namesⁱ	Name:thsB Ordered Locus Names:AF_1451
Organismⁱ	Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifierⁱ	224325 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › Archaeoglobus fulgidus
Proteomesⁱ	UP000002199 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000128382	1 – 545	Thermosome subunit betaAdd BLAST		545

Proteomic databases

PRIDEⁱ	O28821

PRIDEⁱ

O28821

Interactionⁱ

Subunit structureⁱ

Forms a Heterooligomeric complex of two stacked eight-membered rings.By similarity

GO - Molecular functionⁱ

unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	224325.AF1451

STRINGⁱ

224325.AF1451

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O28821
SMRⁱ	O28821
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGⁱ	arCOG01257 Archaea COG0459 LUCA
KEGG Orthology (KO) More...KOⁱ	K22447
OMAⁱ	QFCLSPP
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z02BT

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03343 cpn60, 1 hit
Gene3Dⁱ	1.10.560.10, 2 hits 3.30.260.10, 2 hits 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf IPR012714 Thermosome_arc
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 2 hits SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 2 hits
TIGRFAMsⁱ	TIGR02339 thermosome_arch, 1 hit
PROSITEⁱ	View protein in PROSITE PS00750 TCP1_1, 1 hit PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O28821-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATLQGQPVL ILREGTQRTV GRDAQRMNIM AARVIAEAVR STLGPKGMDK 
        60         70         80         90        100
MLVDSLGDVV ITNDGVTILK EIDVEHPAAK MIIEVAKTQD NEVGDGTTTA 
       110        120        130        140        150
VVLAGELLKR AEELLDQEIH PAIIANGYRY AAEKALEILN EIAIPISKDD 
       160        170        180        190        200
DEILKKIATT AMTGKGAEVA IDKLAEIAVN AVKMIAEESN GQVEVNTDYI 
       210        220        230        240        250
KIEKRQGGSI EETELVDGIV LDKEVVHPGM PKRVENAKIL LLDSALEVKE 
       260        270        280        290        300
TEIDAKIRIT DPEKLQKFIE QEEAMLKEMV DKIVNAGANV VFCQKGIDDL 
       310        320        330        340        350
AQYYLAKAGV LAVRRVKKSD MEKLAKATGA KVLTDLRDIS SEDLGEAALV 
       360        370        380        390        400
EERKVGDEKM VFVTGCKNPK AVTILVRGGT EHVVEEIARG IEDAVRAVAC 
       410        420        430        440        450
AVEDGKVVVG AGAPEIEVSL KLREWAPSLG GREQLAVEAF ATALEIIPRT 
       460        470        480        490        500
LAENAGLDPI DVLVELKAAH EKGQKYAGVD VDTGKVVDMK ERGVFEPLRV 
       510        520        530        540 
KTQAIGSATE VAVMILRIDD IIAAKGLEKE KGGGGEGGMP EMPEF

Length:545

Mass (Da):58,684

Last modified:January 1, 1998 - v1

Checksum:ⁱCA3DA663A4A842F2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE000782 Genomic DNA Translation: AAB89798.1
PIRⁱ	B69431
NCBI Reference Sequences More...RefSeqⁱ	WP_010878948.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaⁱ	AAB89798; AAB89798; AF_1451
GeneIDⁱ	24795063
KEGGⁱ	afu:AF_1451

Protein	Similar proteins		Species	Score	Length
O28821	Thermosome subunit beta		ARCFL		545
Thermosome, various subunit, archaeal		Archaeoglobus fulgidus DSM 8774		545

Protein	Similar proteins		Species	Score	Length
O28821	Thermosome subunit beta		ARCFL		545
Thermosome, various subunit, archaeal		Archaeoglobus fulgidus DSM 8774		545

Protein	Similar proteins		Species	Score	Length
O28821	Thermosome subunit beta		THEKO		546
Thermosome subunit		PYRAB		550
Thermosome, subunit alpha		PYRSN		550
Thermosome subunit		PYRHO		549
UPI0004166359		Carboxydothermus ferrireducens		549
+1105

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE000782 Genomic DNA Translation: AAB89798.1
PIRⁱ	B69431
NCBI Reference Sequences More...RefSeqⁱ	WP_010878948.1, NC_000917.1

3D structure databases

ProteinModelPortalⁱ	O28821
SMRⁱ	O28821
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	224325.AF1451

STRINGⁱ

224325.AF1451

Proteomic databases

PRIDEⁱ	O28821

PRIDEⁱ

O28821

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAB89798; AAB89798; AF_1451
GeneIDⁱ	24795063
KEGGⁱ	afu:AF_1451

Phylogenomic databases

eggNOGⁱ	arCOG01257 Archaea COG0459 LUCA
KEGG Orthology (KO) More...KOⁱ	K22447
OMAⁱ	QFCLSPP
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z02BT

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03343 cpn60, 1 hit
Gene3Dⁱ	1.10.560.10, 2 hits 3.30.260.10, 2 hits 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf IPR012714 Thermosome_arc
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 2 hits SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 2 hits
TIGRFAMsⁱ	TIGR02339 thermosome_arch, 1 hit
PROSITEⁱ	View protein in PROSITE PS00750 TCP1_1, 1 hit PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THSB_ARCFU
Accessionⁱ	O28821Primary (citable) accession number: O28821
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	January 1, 1998
	Last modified:	May 23, 2018
	This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

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UniProtKB - O28821 (THSB_ARCFU)

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Thermosome subunit beta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Molecule processing

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3D structure databases

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ