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Entry version 127 (07 Apr 2021)
Sequence version 1 (01 Jan 1998)
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Protein
Submitted name:

Adenylylsulfate reductase, subunit A (AprA)

Gene

AF_1670

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADARBA annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei74ADP analogCombined sources1
Binding sitei74SubstrateCombined sources1
Binding sitei95ADP analogCombined sources1
Binding sitei95AMPCombined sources1
Binding sitei141SubstrateCombined sources1
Binding sitei145ADP analogCombined sources1
Binding sitei145AMPCombined sources1
Binding sitei214FAD; via carbonyl oxygenCombined sources1
Binding sitei234SubstrateCombined sources1
Binding sitei265ADP analogCombined sources1
Binding sitei265FAD cofactor analogCombined sources1
Binding sitei265SubstrateCombined sources1
Binding sitei277AMPCombined sources1
Binding sitei282AMP; via carbonyl oxygenCombined sources1
Binding sitei317ADP analogCombined sources1
Binding sitei317AMPCombined sources1
Binding sitei361SubstrateCombined sources1
Binding sitei365FADCombined sources1
Binding sitei397FADCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei398Proton donor/acceptorCombined sources1
Binding sitei439FAD cofactor analog; via amide nitrogenCombined sources1
Binding sitei439FAD; via amide nitrogenCombined sources1
Binding sitei449FADCombined sources1
Binding sitei449FAD cofactor analogCombined sources1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei449Important for catalytic activityCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi32 – 33FADCombined sources2
Nucleotide bindingi32 – 33FAD cofactor analogCombined sources2
Nucleotide bindingi56 – 57FADCombined sources2
Nucleotide bindingi56 – 57FAD cofactor analogCombined sources2
Nucleotide bindingi63 – 65FADCombined sources3
Nucleotide bindingi63 – 65FAD cofactor analogCombined sources3
Nucleotide bindingi72 – 74FADCombined sources3
Nucleotide bindingi72 – 74FAD cofactor analogCombined sources3
Nucleotide bindingi175 – 176FADCombined sources2
Nucleotide bindingi175 – 176FAD cofactor analogCombined sources2
Nucleotide bindingi234 – 235FADCombined sources2
Nucleotide bindingi234 – 235FAD cofactor analogCombined sources2
Nucleotide bindingi239 – 242FADCombined sources4
Nucleotide bindingi239 – 242FAD cofactor analogCombined sources4
Nucleotide bindingi264 – 265AMPCombined sources2
Nucleotide bindingi273 – 277ADP analogCombined sources5
Nucleotide bindingi397 – 398FAD cofactor analogCombined sources2
Nucleotide bindingi398 – 399ADP analogCombined sources2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseARBA annotation
LigandFADCombined sources, Flavoprotein, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.8.99.2, 414

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Adenylylsulfate reductase, subunit A (AprA)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:AF_1670Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224325 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002199 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224325.AF_1670

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O28603

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O28603

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 263FAD_binding_2InterPro annotationAdd BLAST240
Domaini520 – 635Succ_DH_flav_CInterPro annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili543 – 563Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG00573, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014312_8_3_2

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARKETRW

Database of Orthologous Groups

More...
OrthoDBi
18247at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.700.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011803, AprA
IPR003953, FAD-binding_2
IPR036188, FAD/NAD-bd_sf
IPR037099, Fum_R/Succ_DH_flav-like_C_sf
IPR015939, Fum_Rdtase/Succ_DH_flav-like_C
IPR011280, Succ_DH/Fum_Rdt_flav_su
IPR027477, Succ_DH/fumarate_Rdtase_cat_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11632:SF53, PTHR11632:SF53, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00890, FAD_binding_2, 1 hit
PF02910, Succ_DH_flav_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46977, SSF46977, 1 hit
SSF51905, SSF51905, 1 hit
SSF56425, SSF56425, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02061, aprA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O28603-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVYYPKKYEL YKADEVPTEV VETDILIIGG GFSGCGAAYE AAYWAKLGGL
60 70 80 90 100
KVTLVEKAAV ERSGAVAQGL SAINTYIDLT GRSERQNTLE DYVRYVTLDM
110 120 130 140 150
MGLAREDLVA DYARHVDGTV HLFEKWGLPI WKTPDGKYVR EGQWQIMIHG
160 170 180 190 200
ESYKPIIAEA AKMAVGEENI YERVFIFELL KDKNDPNAVA GAVGFSVREP
210 220 230 240 250
KFYVFKAKAV ILATGGATLL FRPRSTGEAA GRTWYAIFDT GSGYYMGLKA
260 270 280 290 300
GAMLTQFEHR FIPFRFKDGY GPVGAWFLFF KCKAKNAYGE EYIKTRAAEL
310 320 330 340 350
EKYKPYGAAQ PIPTPLRNHQ VMLEIMDGNQ PIYMHTEEAL AELAGGDKKK
360 370 380 390 400
LKHIYEEAFE DFLDMTVSQA LLWACQNIDP QEQPSEAAPA EPYIMGSHSG
410 420 430 440 450
EAGFWVCGPE DLMPEEYAKL FPLKYNRMTT VKGLFAIGDC AGANPHKFSS
460 470 480 490 500
GSFTEGRIAA KAAVRFILEQ KPNPEIDDAV VEELKKKAYA PMERFMQYKD
510 520 530 540 550
LSTADDVNPE YILPWQGLVR LQKIMDEYAA GIATIYKTNE KMLQRALELL
560 570 580 590 600
AFLKEDLEKL AARDLHELMR AWELVHRVWT AEAHVRHMLF RKETRWPGYY
610 620 630 640
YRTDYPELND EEWKCFVCSK YDAEKDEWTF EKVPYVQVIE WSF
Length:643
Mass (Da):73,270
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA57091382F2E9F4A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89579.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E69458

NCBI Reference Sequences

More...
RefSeqi
WP_010879166.1, NC_000917.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAB89579; AAB89579; AF_1670

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24795413

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afu:AF_1670

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89579.1
PIRiE69458
RefSeqiWP_010879166.1, NC_000917.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JNRX-ray1.60A/C1-643[»]
1JNZX-ray2.50A/C1-643[»]
2FJAX-ray2.00A/C1-643[»]
2FJBX-ray1.70A/C1-643[»]
2FJDX-ray1.84A/C1-643[»]
2FJEX-ray1.80A/C1-643[»]
SMRiO28603
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi224325.AF_1670

Genome annotation databases

EnsemblBacteriaiAAB89579; AAB89579; AF_1670
GeneIDi24795413
KEGGiafu:AF_1670

Phylogenomic databases

eggNOGiarCOG00573, Archaea
HOGENOMiCLU_014312_8_3_2
OMAiARKETRW
OrthoDBi18247at2157

Enzyme and pathway databases

BRENDAi1.8.99.2, 414

Miscellaneous databases

EvolutionaryTraceiO28603

Family and domain databases

Gene3Di3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR011803, AprA
IPR003953, FAD-binding_2
IPR036188, FAD/NAD-bd_sf
IPR037099, Fum_R/Succ_DH_flav-like_C_sf
IPR015939, Fum_Rdtase/Succ_DH_flav-like_C
IPR011280, Succ_DH/Fum_Rdt_flav_su
IPR027477, Succ_DH/fumarate_Rdtase_cat_sf
PANTHERiPTHR11632:SF53, PTHR11632:SF53, 1 hit
PfamiView protein in Pfam
PF00890, FAD_binding_2, 1 hit
PF02910, Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977, SSF46977, 1 hit
SSF51905, SSF51905, 1 hit
SSF56425, SSF56425, 1 hit
TIGRFAMsiTIGR02061, aprA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO28603_ARCFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O28603
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: April 7, 2021
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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