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Protein

Uridylate kinase

Gene

pyrH

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylation of UMP to UDP.UniRule annotation

Catalytic activityi

ATP + UMP = ADP + UDP.UniRule annotation

Activity regulationi

Inhibited by UTP.UniRule annotation

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UDP from UMP (UMPK route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridylate kinase (pyrH)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP from UMP (UMPK route), the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41UMP; via amide nitrogenUniRule annotation1
Binding sitei42ATP; via amide nitrogenUniRule annotation1
Binding sitei46ATPUniRule annotation1
Binding sitei63UMPUniRule annotation1
Binding sitei136ATPUniRule annotation1
Binding sitei137ATPUniRule annotation1
Binding sitei142ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei145ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 10ATPUniRule annotation2
Nucleotide bindingi110 – 116UMPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00159;UER00275

Names & Taxonomyi

Protein namesi
Recommended name:
Uridylate kinaseUniRule annotation (EC:2.7.4.22UniRule annotation)
Short name:
UKUniRule annotation
Alternative name(s):
Uridine monophosphate kinaseUniRule annotation
Short name:
UMP kinaseUniRule annotation
Short name:
UMPKUniRule annotation
Gene namesi
Name:pyrHUniRule annotation
Ordered Locus Names:AF_2042
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439141 – 219Uridylate kinaseAdd BLAST219

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi224325.AF2042

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO28237
SMRiO28237
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO28237

Family & Domainsi

Sequence similaritiesi

Belongs to the UMP kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00858 Archaea
COG0528 LUCA
KOiK09903
OMAiMGGTHPG
OrthoDBiPOG093Z0AM3

Family and domain databases

Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_01220_A PyrH_A, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR011817 Uridylate_kinase
IPR011818 Uridylate_kinase_arch/spir
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PIRSFiPIRSF005650 Uridylate_kin, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR02076 pyrH_arch, 1 hit

Sequencei

Sequence statusi: Complete.

O28237-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVVLSLGGS VLSNESEKIR EFAKTIESVA QQNQVFVVVG GGKLAREYIK
60 70 80 90 100
RARELGASET FCDYIGIAAT RLNAMLLISA IPSAAKKVPV DFMEAEELSK
110 120 130 140 150
LYRVVVMGGT FPGHTTDATA ALLAEFIKAD VFINATNVDG VYSADPKSDT
160 170 180 190 200
SAVKYDRLSP QQLVEIVSRS SAKAGTNVVI DLLAAKIIER SKIKTYVILG
210
TPENIMKAVK GEAVGTVIA
Length:219
Mass (Da):23,398
Last modified:January 1, 1998 - v1
Checksum:i751B894ED5261B91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89213.1
PIRiA69505
RefSeqiWP_010879534.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB89213; AAB89213; AF_2042
GeneIDi24795791
KEGGiafu:AF_2042

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89213.1
PIRiA69505
RefSeqiWP_010879534.1, NC_000917.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IJ9X-ray2.90A/B1-219[»]
ProteinModelPortaliO28237
SMRiO28237
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF2042

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89213; AAB89213; AF_2042
GeneIDi24795791
KEGGiafu:AF_2042

Phylogenomic databases

eggNOGiarCOG00858 Archaea
COG0528 LUCA
KOiK09903
OMAiMGGTHPG
OrthoDBiPOG093Z0AM3

Enzyme and pathway databases

UniPathwayi
UPA00159;UER00275

Miscellaneous databases

EvolutionaryTraceiO28237

Family and domain databases

Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_01220_A PyrH_A, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR011817 Uridylate_kinase
IPR011818 Uridylate_kinase_arch/spir
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PIRSFiPIRSF005650 Uridylate_kin, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR02076 pyrH_arch, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYRH_ARCFU
AccessioniPrimary (citable) accession number: O28237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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