UniProtKB - O28219 (RFCS_ARCFU)
Protein
Replication factor C small subunit
Gene
rfcS
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Functioni
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 45 – 52 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- DNA clamp loader activity Source: UniProtKB-UniRule
GO - Biological processi
- DNA replication Source: UniProtKB-UniRule
Keywordsi
Biological process | DNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.4.B8, 414 |
Names & Taxonomyi
Protein namesi | Recommended name: Replication factor C small subunitShort name: RFC small subunit Alternative name(s): Clamp loader small subunit afRFC small subunit Short name: afRFCsm |
Gene namesi | Name:rfcS Ordered Locus Names:AF_2060 |
Organismi | Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) |
Taxonomic identifieri | 224325 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000135971 | 1 – 319 | Replication factor C small subunitAdd BLAST | 319 |
Interactioni
Subunit structurei
Heteropentamer composed of four small subunits (RfcS) and one large subunit (RfcL). Both subunits interact with PCNA.
1 PublicationProtein-protein interaction databases
STRINGi | 224325.AF_2060 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O28219 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O28219 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | arCOG00469, Archaea |
HOGENOMi | CLU_042324_1_0_2 |
OMAi | TEGANER |
OrthoDBi | 37207at2157 |
Family and domain databases
HAMAPi | MF_01509, RfcS, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR008921, DNA_pol3_clamp-load_cplx_C IPR027417, P-loop_NTPase IPR023748, Rep_factor-C_ssu_arc IPR013748, Rep_factorC_C |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF08542, Rep_fac_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF48019, SSF48019, 1 hit SSF52540, SSF52540, 1 hit |
i Sequence
Sequence statusi: Complete.
O28219-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENFEIWVEK YRPRTLDEVV GQDEVIQRLK GYVERKNIPH LLFSGPPGTG
60 70 80 90 100
KTATAIALAR DLFGENWRDN FIEMNASDER GIDVVRHKIK EFARTAPIGG
110 120 130 140 150
APFKIIFLDE ADALTADAQA ALRRTMEMYS KSCRFILSCN YVSRIIEPIQ
160 170 180 190 200
SRCAVFRFKP VPKEAMKKRL LEICEKEGVK ITEDGLEALI YISGGDFRKA
210 220 230 240 250
INALQGAAAI GEVVDADTIY QITATARPEE MTELIQTALK GNFMEARELL
260 270 280 290 300
DRLMVEYGMS GEDIVAQLFR EIISMPIKDS LKVQLIDKLG EVDFRLTEGA
310
NERIQLDAYL AYLSTLAKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000782 Genomic DNA Translation: AAB89191.1 |
PIRi | C69507 |
RefSeqi | WP_010879552.1, NC_000917.1 |
Genome annotation databases
EnsemblBacteriai | AAB89191; AAB89191; AF_2060 |
GeneIDi | 24795809 |
KEGGi | afu:AF_2060 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000782 Genomic DNA Translation: AAB89191.1 |
PIRi | C69507 |
RefSeqi | WP_010879552.1, NC_000917.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CHG | X-ray | 2.10 | A/B/C/D | 1-226 | [»] | |
2CHQ | X-ray | 3.50 | A/B/C | 1-319 | [»] | |
2CHV | X-ray | 4.00 | A/B/C/D/E/F | 1-319 | [»] | |
SMRi | O28219 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 224325.AF_2060 |
Genome annotation databases
EnsemblBacteriai | AAB89191; AAB89191; AF_2060 |
GeneIDi | 24795809 |
KEGGi | afu:AF_2060 |
Phylogenomic databases
eggNOGi | arCOG00469, Archaea |
HOGENOMi | CLU_042324_1_0_2 |
OMAi | TEGANER |
OrthoDBi | 37207at2157 |
Enzyme and pathway databases
BRENDAi | 3.6.4.B8, 414 |
Miscellaneous databases
EvolutionaryTracei | O28219 |
Family and domain databases
HAMAPi | MF_01509, RfcS, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR008921, DNA_pol3_clamp-load_cplx_C IPR027417, P-loop_NTPase IPR023748, Rep_factor-C_ssu_arc IPR013748, Rep_factorC_C |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF08542, Rep_fac_C, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF48019, SSF48019, 1 hit SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RFCS_ARCFU | |
Accessioni | O28219Primary (citable) accession number: O28219 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | January 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families