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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124SubstrateUniRule annotation1
Binding sitei149SubstrateUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Binding sitei183SubstrateUniRule annotation1
Binding sitei184NADUniRule annotation1
Binding sitei236NADUniRule annotation1
Binding sitei271NADUniRule annotation1
Binding sitei339NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 152NADUniRule annotation3
Nucleotide bindingi213 – 218NADUniRule annotation6
Nucleotide bindingi292 – 294NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-1589-MONOMER
UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:MTH_1636
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001170081 – 417AdenosylhomocysteinaseAdd BLAST417

Proteomic databases

PRIDEiO27673

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1636

Structurei

3D structure databases

ProteinModelPortaliO27673
SMRiO27673
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04137 Archaea
COG0499 LUCA
KOiK01251
OMAiTGNRDII
OrthoDBiPOG093Z03XF

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 2 hits
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O27673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYKVKDISL APQGEKKIRW VQEHMPVLER IKSDFSEEKP FKGVTIGSCL
60 70 80 90 100
HLEPKTINLG LTLQAGGAEV AMTGCNPLST QDDATAAGAK MGLNMYGWRG
110 120 130 140 150
ETNEEYYENI HRVLDHEPEI LIDDGADMIF LVHRERPELL DGIIGACEET
160 170 180 190 200
TTGINRLRAM AADGALKFPV MAVNDAYTKY LFDNRYGTGQ STFDSIMGTT
210 220 230 240 250
NMLIAGKTVV VCGYGWCGRG IAMRAEGLGA SVIVTEVDPI RALEARMDGF
260 270 280 290 300
RVMKVSDAVK EADILITATG NTDVVSESEF MNMKDGCVMA NSGHFNVEIN
310 320 330 340 350
REALEELSRE TGKVKEDIEV FIMPDGRKIY LLAEGRLVNL ASERGQGHPA
360 370 380 390 400
EIMDMSFAMQ ALSARHLLQE KPDPGVYRAP DEIDLMVARM KLDAMGIEID
410
ELTEKQRLYL ENWEEGT
Length:417
Mass (Da):46,169
Last modified:January 1, 1998 - v1
Checksum:i793A940867EFEB74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB86109.1
PIRiF69085
RefSeqiWP_010877244.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB86109; AAB86109; MTH_1636
GeneIDi1470721
KEGGimth:MTH_1636
PATRICifig|187420.15.peg.1600

Similar proteinsi

Entry informationi

Entry nameiSAHH_METTH
AccessioniPrimary (citable) accession number: O27673
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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