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Protein

Probable tRNA pseudouridine synthase D

Gene

truD

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-1481-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:MTH_1529
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525461 – 415Probable tRNA pseudouridine synthase DAdd BLAST415

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1529

Structurei

3D structure databases

ProteinModelPortaliO27572
SMRiO27572
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 376TRUDUniRule annotationAdd BLAST221

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
KOiK06176
OMAiLRYERAM
OrthoDBiPOG093Z087N

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

O27572-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNAETYVTS TEGTGGRIRV HNRDFEVEEI PLTEPSGSGP NTWIWIEKEG
60 70 80 90 100
RTTLDVLLDI ARELHLDRRR MGFAGMKDKR AVTRQWICVS NTAPSEVKAI
110 120 130 140 150
EERIRNVKFL RVTANEKKLR MGQLLGNRFR ILIRDTEIDE PLETAKATLQ
160 170 180 190 200
ELEDKGVPNY YGWQRFGSPR ANTHLVGRAL VHGDVKGAVD SYIGNPLEGE
210 220 230 240 250
SEIVSEARRA YDRGDLEEAY ELMPSSMRYE RMMLRPMLRD LRRGEFSDES
260 270 280 290 300
YVRAIHALPK PLKRMFVHAY QSYLFNRAVS ERAALGINTH IPGDIVIDND
310 320 330 340 350
QHIIHDADPD ELEELILNFE AHPTAPLYGS KVPLASGRPG EIERRILEDE
360 370 380 390 400
GVSLEDFNSI KVPKLGSHGM RRAIRFRIWD VDAHESQEGL TVEFSIPRGC
410
YATSVLREIM KKDVV
Length:415
Mass (Da):47,347
Last modified:January 1, 1998 - v1
Checksum:i10E4063BCA150183
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB86003.1
PIRiH69070
RefSeqiWP_010877138.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB86003; AAB86003; MTH_1529
GeneIDi1471798
KEGGimth:MTH_1529
PATRICifig|187420.15.peg.1491

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB86003.1
PIRiH69070
RefSeqiWP_010877138.1, NC_000916.1

3D structure databases

ProteinModelPortaliO27572
SMRiO27572
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1529

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB86003; AAB86003; MTH_1529
GeneIDi1471798
KEGGimth:MTH_1529
PATRICifig|187420.15.peg.1491

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
KOiK06176
OMAiLRYERAM
OrthoDBiPOG093Z087N

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-1481-MONOMER

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_METTH
AccessioniPrimary (citable) accession number: O27572
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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