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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).By similarity

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Mg2+By similarity

Activity regulationi

Feedback inhibited by histidine.By similarity

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-1458-MONOMER
UniPathwayi
UPA00031;UER00006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase (EC:2.4.2.17)
Short name:
ATP-PRT
Short name:
ATP-PRTase
Gene namesi
Name:hisG
Ordered Locus Names:MTH_1506
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001518861 – 287ATP phosphoribosyltransferaseAdd BLAST287

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1506

Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO27550
SMRiO27550
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO27550

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG02208 Archaea
COG0040 LUCA
KOiK00765
OMAiYVMMDYD
OrthoDBiPOG093Z06DC

Family and domain databases

Gene3Di3.30.70.120, 1 hit
HAMAPiMF_00079 HisG_Long, 1 hit
InterProiView protein in InterPro
IPR013820 ATP_PRibTrfase_cat
IPR018198 ATP_PRibTrfase_CS
IPR001348 ATP_PRibTrfase_HisG
IPR020621 ATP_PRibTrfase_HisG_long
IPR013115 HisG_C
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
PANTHERiPTHR21403 PTHR21403, 1 hit
PfamiView protein in Pfam
PF01634 HisG, 1 hit
PF08029 HisG_C, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit
TIGRFAMsiTIGR00070 hisG, 1 hit
TIGR03455 HisG_C-term, 1 hit
PROSITEiView protein in PROSITE
PS01316 ATP_P_PHORIBOSYLTR, 1 hit

Sequencei

Sequence statusi: Complete.

O27550-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIRIAVPSK GRISEPAIRL LENAGVGLKD TVNRKLFSKT QHPQIEVMFS
60 70 80 90 100
RAADIPEFVA DGAADLGITG YDLIVERGSD VEILEDLKYG RASLVLAAPE
110 120 130 140 150
DSTIRGPEDI PRGAVIATEF PGITENYLRE HGIDAEVVEL TGSTEIAPFI
160 170 180 190 200
GVADLITDLS STGTTLRMNH LRVIDTILES SVKLIANRES YATKSGIIEE
210 220 230 240 250
LRTGIRGVID AEGKRLVMLN IDRKNLDRVR ALMPGMTGPT VSEVLSDNGV
260 270 280
VAVHAVVDEK EVFNLINRLK AVGARDILVV PIERIIP
Length:287
Mass (Da):31,165
Last modified:January 1, 1998 - v1
Checksum:iEFAA5D8BF9755F48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85981.1
PIRiH69067
RefSeqiWP_010877116.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB85981; AAB85981; MTH_1506
GeneIDi1471775
KEGGimth:MTH_1506
PATRICifig|187420.15.peg.1469

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85981.1
PIRiH69067
RefSeqiWP_010877116.1, NC_000916.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VD3X-ray2.45A/B2-287[»]
ProteinModelPortaliO27550
SMRiO27550
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1506

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB85981; AAB85981; MTH_1506
GeneIDi1471775
KEGGimth:MTH_1506
PATRICifig|187420.15.peg.1469

Phylogenomic databases

eggNOGiarCOG02208 Archaea
COG0040 LUCA
KOiK00765
OMAiYVMMDYD
OrthoDBiPOG093Z06DC

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00006

BioCyciMTHE187420:G1G16-1458-MONOMER

Miscellaneous databases

EvolutionaryTraceiO27550

Family and domain databases

Gene3Di3.30.70.120, 1 hit
HAMAPiMF_00079 HisG_Long, 1 hit
InterProiView protein in InterPro
IPR013820 ATP_PRibTrfase_cat
IPR018198 ATP_PRibTrfase_CS
IPR001348 ATP_PRibTrfase_HisG
IPR020621 ATP_PRibTrfase_HisG_long
IPR013115 HisG_C
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
PANTHERiPTHR21403 PTHR21403, 1 hit
PfamiView protein in Pfam
PF01634 HisG, 1 hit
PF08029 HisG_C, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit
TIGRFAMsiTIGR00070 hisG, 1 hit
TIGR03455 HisG_C-term, 1 hit
PROSITEiView protein in PROSITE
PS01316 ATP_P_PHORIBOSYLTR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHIS1_METTH
AccessioniPrimary (citable) accession number: O27550
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 10, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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