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Entry version 129 (12 Aug 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit E

Gene

gatE

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:MONOMER-14999
MTHE187420:G1G16-672-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit E (EC:6.3.5.-)
Short name:
Glu-ADT subunit E
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gatE
Ordered Locus Names:MTH_707
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri187420 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005223 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001400751 – 619Glutamyl-tRNA(Gln) amidotransferase subunit EAdd BLAST619

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O26803

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of GatD and GatE.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1619
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O26803

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O26803

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GatB/GatE family. GatE subfamily.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030702_0_0_2

KEGG Orthology (KO)

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KOi
K03330

Identification of Orthologs from Complete Genome Data

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OMAi
SGFQRTM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.410, 1 hit
1.10.150.380, 1 hit
3.30.1360.30, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00588, GatE, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017959, Asn/Gln-tRNA_amidoTrfase_suB/E
IPR006075, Asn/Gln-tRNA_Trfase_suB/E_cat
IPR018027, Asn/Gln_amidotransferase
IPR003789, Asn/Gln_tRNA_amidoTrase-B-like
IPR004115, GAD-like_sf
IPR029351, GAD_dom
IPR042114, GatB_C_1
IPR023168, GatB_Yqey_C_2
IPR004414, GatE
IPR017958, Gln-tRNA_amidoTrfase_suB_CS
IPR014746, Gln_synth/guanido_kin_cat_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11659, PTHR11659, 1 hit
PTHR11659:SF2, PTHR11659:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02938, GAD, 1 hit
PF02934, GatB_N, 1 hit
PF02637, GatB_Yqey, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00845, GatB_Yqey, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55261, SSF55261, 1 hit
SSF55931, SSF55931, 1 hit
SSF89095, SSF89095, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00134, gatE_arch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01234, GATB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O26803-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDWEKVGLKM GLEIHQQLDT ESKLFCPCRT ELTDSEPDHD IVRNLRPTQS
60 70 80 90 100
ELGKFDRAAF EEAMRKLHFH YENYHEETCL VEADEEPPHP LNPEALEIAV
110 120 130 140 150
TIALLLNMRV VDEFHTMRKQ VIDGSNTGGF QRTGLVATDG HLETPQGTVK
160 170 180 190 200
IENLCLEEDA ARRIRETGDG VVFRLDRLGI PLVEITTDPS MSDPQQLREV
210 220 230 240 250
AYQIGQILRS TRVKRGLGTI RQDLNISIRD GARVEVKGVQ DLDLIPEIVE
260 270 280 290 300
REVKRQLSLV EIRDTLQERG AVVEDKIFDV SEVFADTESR IISSAESVLA
310 320 330 340 350
VKLRGFDGLI GVEIQPGRRL GTEMADYAKK RGVSGIFHTD ELPAYGITEE
360 370 380 390 400
EVRGLRDAVG ASQGDAVVMV AHERVTAENA LREVIRRAEM AIQGVPEETR
410 420 430 440 450
KALPDGNTQY LRPLPTSSRM YLETDIPLFR IEDDLLEGIR RNLPELPSEK
460 470 480 490 500
KERIMRDYGL SEDLASQLVK RNLVDEFEAL TEFRVDTTVI ASLLAYTLRE
510 520 530 540 550
LRREGHDVDG LGLDELRDAI KLLEVGKISK DALRDIVACM ADEGLAAEDA
560 570 580 590 600
ARKLNLLLLA EDEIESIIQE IVEGNLDMIS ERGMGAMGPL MGQAMGRLRG
610
RADGKVVNRI LREKIQERL
Length:619
Mass (Da):69,533
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD362944674300A32
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85212.1

Protein sequence database of the Protein Information Resource

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PIRi
D69194

NCBI Reference Sequences

More...
RefSeqi
WP_010876346.1, NC_000916.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAB85212; AAB85212; MTH_707

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1470668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mth:MTH_707

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|187420.15.peg.690

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85212.1
PIRiD69194
RefSeqiWP_010876346.1, NC_000916.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D6FX-ray3.15C/D1-619[»]
SMRiO26803
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiO26803

Genome annotation databases

EnsemblBacteriaiAAB85212; AAB85212; MTH_707
GeneIDi1470668
KEGGimth:MTH_707
PATRICifig|187420.15.peg.690

Phylogenomic databases

HOGENOMiCLU_030702_0_0_2
KOiK03330
OMAiSGFQRTM

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14999
MTHE187420:G1G16-672-MONOMER

Miscellaneous databases

EvolutionaryTraceiO26803

Family and domain databases

Gene3Di1.10.10.410, 1 hit
1.10.150.380, 1 hit
3.30.1360.30, 1 hit
HAMAPiMF_00588, GatE, 1 hit
InterProiView protein in InterPro
IPR017959, Asn/Gln-tRNA_amidoTrfase_suB/E
IPR006075, Asn/Gln-tRNA_Trfase_suB/E_cat
IPR018027, Asn/Gln_amidotransferase
IPR003789, Asn/Gln_tRNA_amidoTrase-B-like
IPR004115, GAD-like_sf
IPR029351, GAD_dom
IPR042114, GatB_C_1
IPR023168, GatB_Yqey_C_2
IPR004414, GatE
IPR017958, Gln-tRNA_amidoTrfase_suB_CS
IPR014746, Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11659, PTHR11659, 1 hit
PTHR11659:SF2, PTHR11659:SF2, 1 hit
PfamiView protein in Pfam
PF02938, GAD, 1 hit
PF02934, GatB_N, 1 hit
PF02637, GatB_Yqey, 1 hit
SMARTiView protein in SMART
SM00845, GatB_Yqey, 1 hit
SUPFAMiSSF55261, SSF55261, 1 hit
SSF55931, SSF55931, 1 hit
SSF89095, SSF89095, 1 hit
TIGRFAMsiTIGR00134, gatE_arch, 1 hit
PROSITEiView protein in PROSITE
PS01234, GATB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGATE_METTH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O26803
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: August 12, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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