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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33UniRule annotation1
Metal bindingi33MagnesiumUniRule annotation1
Binding sitei51SubstrateUniRule annotation1
Active sitei82Proton acceptorUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei85SubstrateUniRule annotation1
Binding sitei204SubstrateUniRule annotation1
Metal bindingi223MagnesiumUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-213-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:MTH_232
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001237341 – 255Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)Add BLAST255

Proteomic databases

PRIDEiO26334

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi187420.MTH232

Structurei

3D structure databases

ProteinModelPortaliO26334
SMRiO26334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4
Regioni79 – 81Substrate bindingUniRule annotation3
Regioni210 – 212Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01532 Archaea
COG0020 LUCA
KOiK15888
OMAiFDRRDLW
OrthoDBiPOG093Z09YM

Family and domain databases

CDDicd00475 Cis_IPPS, 1 hit
Gene3Di3.40.1180.10, 1 hit
HAMAPiMF_01139 ISPT, 1 hit
InterProiView protein in InterPro
IPR001441 UPP_synth-like
IPR018520 UPP_synth-like_CS
IPR036424 UPP_synth-like_sf
PANTHERiPTHR10291 PTHR10291, 1 hit
PfamiView protein in Pfam
PF01255 Prenyltransf, 1 hit
SUPFAMiSSF64005 SSF64005, 1 hit
TIGRFAMsiTIGR00055 uppS, 1 hit
PROSITEiView protein in PROSITE
PS01066 UPP_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

O26334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLKPLYKL YEWYISRNLR RDRMPRHVAI IMDGNRRYSK LQGSMNPIEG
60 70 80 90 100
HKKGIETLEK VLDWCVDLGI EIVTAYAFST ENFKRPEKEV KGLMKLFREN
110 120 130 140 150
FEAIASNEKI HKNRVRVRAV GKLELLPEDV RRAIEIAEKS TEQYSDRLVN
160 170 180 190 200
IAIGYDGRQE IVDATRKIAE DVKAGLIDPE DIDEDMINRN LYTAGLEDPH
210 220 230 240 250
LIIRTSGEER LSGFLLWQSS YSELYFCDSL WPELRKVDFL RAIRSYQQRE

RRFGV
Length:255
Mass (Da):29,900
Last modified:January 1, 1998 - v1
Checksum:i370C6D8F85FFB8D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB84738.1
PIRiH69128
RefSeqiWP_010875871.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB84738; AAB84738; MTH_232
GeneIDi1470193
KEGGimth:MTH_232
PATRICifig|187420.15.peg.201

Similar proteinsi

Entry informationi

Entry nameiUPPS_METTH
AccessioniPrimary (citable) accession number: O26334
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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