UniProtKB - O26253 (NADM_METTH)
Protein
Nicotinamide-nucleotide adenylyltransferase
Gene
MTH_150
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Functioni
Catalytic activityi
- EC:2.7.7.1
: NAD(+) biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide.Proteins known to be involved in this subpathway in this organism are:
- Nicotinamide-nucleotide adenylyltransferase (MTH_150)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- nicotinamide-nucleotide adenylyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- NAD biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Pyridine nucleotide biosynthesis |
Ligand | ATP-binding, NAD, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MTHE187420:G1G16-137-MONOMER |
BRENDAi | 2.7.7.1, 3256 |
SABIO-RKi | O26253 |
UniPathwayi | UPA00253;UER00600 |
Names & Taxonomyi
Protein namesi | Recommended name: Nicotinamide-nucleotide adenylyltransferase (EC:2.7.7.1)Alternative name(s): NAD(+) diphosphorylase NAD(+) pyrophosphorylase NMN adenylyltransferase |
Gene namesi | Ordered Locus Names:MTH_150 |
Organismi | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) |
Taxonomic identifieri | 187420 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanomada group › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000134995 | 1 – 178 | Nicotinamide-nucleotide adenylyltransferaseAdd BLAST | 178 |
Proteomic databases
PRIDEi | O26253 |
Interactioni
Subunit structurei
Homohexamer.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O26253 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O26253 |
Family & Domainsi
Sequence similaritiesi
Belongs to the archaeal NMN adenylyltransferase family.Curated
Phylogenomic databases
HOGENOMi | CLU_108783_0_0_2 |
OMAi | NSVWVSH |
Family and domain databases
CDDi | cd02166, NMNAT_Archaea, 1 hit |
Gene3Di | 3.40.50.620, 1 hit |
HAMAPi | MF_00243, NMN_adenylyltr, 1 hit |
InterProi | View protein in InterPro IPR004821, Cyt_trans-like IPR006418, NMN_Atrans_arc IPR014729, Rossmann-like_a/b/a_fold |
Pfami | View protein in Pfam PF01467, CTP_transf_like, 1 hit |
TIGRFAMsi | TIGR01527, arch_NMN_Atrans, 1 hit TIGR00125, cyt_tran_rel, 1 hit |
i Sequence
Sequence statusi: Complete.
O26253-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGLLVGRMQ PFHRGHLQVI KSILEEVDEL IICIGSAQLS HSIRDPFTAG
60 70 80 90 100
ERVMMLTKAL SENGIPASRY YIIPVQDIEC NALWVGHIKM LTPPFDRVYS
110 120 130 140 150
GNPLVQRLFS EDGYEVTAPP LFYRDRYSGT EVRRRMLDDG DWRSLLPESV
160 170
VEVIDEINGV ERIKHLAKKE VSELGGIS
Sequence cautioni
The sequence AAB84656 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000666 Genomic DNA Translation: AAB84656.1 Different initiation. |
PIRi | A69067 |
RefSeqi | WP_048060754.1, NC_000916.1 |
Genome annotation databases
EnsemblBacteriai | AAB84656; AAB84656; MTH_150 |
GeneIDi | 1470111 |
KEGGi | mth:MTH_150 |
PATRICi | fig|187420.15.peg.122 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000666 Genomic DNA Translation: AAB84656.1 Different initiation. |
PIRi | A69067 |
RefSeqi | WP_048060754.1, NC_000916.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EJ2 | X-ray | 1.90 | A | 1-178 | [»] | |
1HYB | X-ray | 2.00 | A | 1-178 | [»] | |
1M8F | X-ray | 2.40 | A | 1-178 | [»] | |
1M8G | X-ray | 2.00 | A | 1-178 | [»] | |
1M8J | X-ray | 2.40 | A | 1-178 | [»] | |
1M8K | X-ray | 3.00 | A/B/C | 1-178 | [»] | |
4YP5 | X-ray | 2.21 | A/B/C | 1-178 | [»] | |
4YP6 | X-ray | 1.90 | A/B/C | 1-178 | [»] | |
4YP7 | X-ray | 2.30 | A/B/C | 1-178 | [»] | |
SMRi | O26253 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PRIDEi | O26253 |
Genome annotation databases
EnsemblBacteriai | AAB84656; AAB84656; MTH_150 |
GeneIDi | 1470111 |
KEGGi | mth:MTH_150 |
PATRICi | fig|187420.15.peg.122 |
Phylogenomic databases
HOGENOMi | CLU_108783_0_0_2 |
OMAi | NSVWVSH |
Enzyme and pathway databases
UniPathwayi | UPA00253;UER00600 |
BioCyci | MTHE187420:G1G16-137-MONOMER |
BRENDAi | 2.7.7.1, 3256 |
SABIO-RKi | O26253 |
Miscellaneous databases
EvolutionaryTracei | O26253 |
Family and domain databases
CDDi | cd02166, NMNAT_Archaea, 1 hit |
Gene3Di | 3.40.50.620, 1 hit |
HAMAPi | MF_00243, NMN_adenylyltr, 1 hit |
InterProi | View protein in InterPro IPR004821, Cyt_trans-like IPR006418, NMN_Atrans_arc IPR014729, Rossmann-like_a/b/a_fold |
Pfami | View protein in Pfam PF01467, CTP_transf_like, 1 hit |
TIGRFAMsi | TIGR01527, arch_NMN_Atrans, 1 hit TIGR00125, cyt_tran_rel, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NADM_METTH | |
Accessioni | O26253Primary (citable) accession number: O26253 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families