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UniProtKB - O26244 (MFNB_METTH)
Protein
(5-formylfuran-3-yl)methyl phosphate synthase
Gene
mfnB
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Functioni
Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
UniRule annotationCatalytic activityi
- 2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphateUniRule annotationEC:4.2.3.153UniRule annotation
: methanofuran biosynthesis Pathwayi
This protein is involved in the pathway methanofuran biosynthesis, which is part of Cofactor biosynthesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway methanofuran biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 27 | Schiff-base intermediate with substrateUniRule annotation | 1 | |
Active sitei | 85 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- carbon-carbon lyase activity Source: UniProtKB-UniRule
GO - Biological processi
- methanofuran biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Lyase |
Ligand | Schiff base |
Enzyme and pathway databases
UniPathwayi | UPA00080 |
Names & Taxonomyi
Protein namesi | Recommended name: (5-formylfuran-3-yl)methyl phosphate synthaseUniRule annotation (EC:4.2.3.153UniRule annotation)Alternative name(s): 4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate synthaseUniRule annotation Short name: 4-HFC-P synthaseUniRule annotation |
Gene namesi | Name:mfnBUniRule annotation Ordered Locus Names:MTH_141 |
Organismi | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) |
Taxonomic identifieri | 187420 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanomada group › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000134868 | 1 – 236 | (5-formylfuran-3-yl)methyl phosphate synthaseAdd BLAST | 236 |
Family & Domainsi
Sequence similaritiesi
Belongs to the MfnB family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_068659_0_0_2 |
OMAi | NFPWVIR |
Family and domain databases
HAMAPi | MF_00681, MfnB, 1 hit |
InterProi | View protein in InterPro IPR007565, 4HFCP_synth IPR035081, 4HFCP_synth_arc |
Pfami | View protein in Pfam PF04476, 4HFCP_synth, 1 hit |
PIRSFi | PIRSF015957, UCP015957, 1 hit |
i Sequence
Sequence statusi: Complete.
O26244-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLLISPINT EEALEAIEGG ADIVDVKNPA EGSLGANFPW VIRRVREMTP
60 70 80 90 100
EDMLVSATLG DVPYKPGTVS LAAMGALVSG ADYIKVGLYG TRNYDEAVDV
110 120 130 140 150
MKNVVRAVKD QSDAIVVAAG YADAHRVGAV EPMEIPRVAA DSGADLAMLD
160 170 180 190 200
TAVKDGKTLF DFMDMEKLES FVSAARDHGL KSALAGSVGR EHLKPLHEIG
210 220 230
CDVVGIRGAA CVGGDRNTGR IHRDAVRELK ELLDSF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000666 Genomic DNA Translation: AAB84647.1 |
PIRi | G69054 |
RefSeqi | WP_010875780.1, NC_000916.1 |
Genome annotation databases
EnsemblBacteriai | AAB84647; AAB84647; MTH_141 |
GeneIDi | 1470102 |
KEGGi | mth:MTH_141 |
PATRICi | fig|187420.15.peg.114 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000666 Genomic DNA Translation: AAB84647.1 |
PIRi | G69054 |
RefSeqi | WP_010875780.1, NC_000916.1 |
3D structure databases
SMRi | O26244 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 187420.MTH_141 |
Genome annotation databases
EnsemblBacteriai | AAB84647; AAB84647; MTH_141 |
GeneIDi | 1470102 |
KEGGi | mth:MTH_141 |
PATRICi | fig|187420.15.peg.114 |
Phylogenomic databases
HOGENOMi | CLU_068659_0_0_2 |
OMAi | NFPWVIR |
Enzyme and pathway databases
UniPathwayi | UPA00080 |
Family and domain databases
HAMAPi | MF_00681, MfnB, 1 hit |
InterProi | View protein in InterPro IPR007565, 4HFCP_synth IPR035081, 4HFCP_synth_arc |
Pfami | View protein in Pfam PF04476, 4HFCP_synth, 1 hit |
PIRSFi | PIRSF015957, UCP015957, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MFNB_METTH | |
Accessioni | O26244Primary (citable) accession number: O26244 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2003 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families