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Protein
Submitted name:

Cation-transporting ATPase, P-type (CopA)

Gene

HP_1503

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93PROSITE-ProRule annotation1
Metal bindingi96PROSITE-ProRule annotation1

GO - Molecular functioni

  • copper-transporting ATPase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • nucleotide binding Source: InterPro

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMetal-bindingPROSITE-ProRule annotation

Enzyme and pathway databases

BioCyciHPY:HP1503-MONOMER

Names & Taxonomyi

Protein namesi
Submitted name:
Cation-transporting ATPase, P-type (CopA)Imported
Gene namesi
Ordered Locus Names:HP_1503Imported
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei165 – 185HelicalUniRule annotationAdd BLAST21
Transmembranei214 – 232HelicalUniRule annotationAdd BLAST19
Transmembranei244 – 266HelicalUniRule annotationAdd BLAST23
Transmembranei425 – 446HelicalUniRule annotationAdd BLAST22
Transmembranei452 – 481HelicalUniRule annotationAdd BLAST30
Transmembranei735 – 759HelicalUniRule annotationAdd BLAST25
Transmembranei765 – 783HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO26033

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ureIQ090683EBI-7498734,EBI-7667832

Protein-protein interaction databases

DIPiDIP-3099N
IntActiO26033, 8 interactors
MINTiO26033
STRINGi85962.HP1503

Structurei

3D structure databases

ProteinModelPortaliO26033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 148HMAInterPro annotationAdd BLAST66

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105C59 Bacteria
COG2217 LUCA
KOiK17686
OMAiCAACGWL

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR021993 ATPase-cat-bd
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF12156 ATPase-cat_bd, 1 hit
PF00403 HMA, 1 hit
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

O26033-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKCSHCQLEF KESELFKEVI NHKELHFCCT GCARVYALLL DLNLESFYDK
60 70 80 90 100
LNDSTLAPVT PQDSMSALEL EQALEENNKG DFILNLLLEK THCNACLWLN
110 120 130 140 150
QKVLERLSGV KKVSVNFTTH HLQIVFEKSL NPKEIIQKIE SLGYGAKIYN
160 170 180 190 200
AQNYTLKAQK EQRSYLLTLS VGFFATMNLM FIAIAKYASY GGASYGGANY
210 220 230 240 250
GAGMDKLMQR NLDLVSLFLS LLVLVVVGRF FIKGAFYGLK NGVLGMDLSV
260 270 280 290 300
SFGALSAFVY SVYAMLVSQE TYFEASSTIL TLVFGSKFLE LKARLFANEK
310 320 330 340 350
CLALESHEIH SVIVVENGKQ TEKHPKDVAI GSVVWVPSGA KIALDGVLLN
360 370 380 390 400
NASVDASLIS GEFKPLELGV NDPILGGYVN VGVPFSYQVS ANFQNSRLSG
410 420 430 440 450
LLETLKKSFL EKPLIESSAN QIADIFSKAV LFLAFVSFLL WQFGLGGNFE
460 470 480 490 500
KALMVCISVL VISCPCAFAL ATPIALVIGV FKNPLIVFKE ALFLETLAKV
510 520 530 540 550
KKIFIDKTGT LTQKEVLLKE KIIYEEFDGR LLKSLLKVRE HLAHSAILKS
560 570 580 590 600
LDGDEVSLEK IEFFAHGLKA SYQNETLLVG SLKFLGSMGV DIPMKESANI
610 620 630 640 650
MVGFAKNETL CALFILEERL KANAKEVVQA LQNKGLELEI LSGDNESSVK
660 670 680 690 700
ECAKKLGISN YHAHLTPEDK AQTISSYKGV CAMVGDGNND ALALKQASVS
710 720 730 740 750
LGFEKSALSK SACDILLLEE DLSLLKKAFD NAQKVYQVVL QNIVLSLIYN
760 770 780
AILIPVAMLG YINPLIASLS MSASSLLVVL NSLRLKRS
Length:788
Mass (Da):86,535
Last modified:January 1, 1998 - v1
Checksum:i4A26106CF6CDBB85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08539.1
PIRiG64707
RefSeqiNP_208294.1, NC_000915.1
WP_000650233.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08539; AAD08539; HP_1503
GeneIDi899788
KEGGiheo:C694_07785
hpy:HP1503
PATRICifig|85962.47.peg.1616

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08539.1
PIRiG64707
RefSeqiNP_208294.1, NC_000915.1
WP_000650233.1, NC_018939.1

3D structure databases

ProteinModelPortaliO26033
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3099N
IntActiO26033, 8 interactors
MINTiO26033
STRINGi85962.HP1503

Proteomic databases

PaxDbiO26033

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08539; AAD08539; HP_1503
GeneIDi899788
KEGGiheo:C694_07785
hpy:HP1503
PATRICifig|85962.47.peg.1616

Phylogenomic databases

eggNOGiENOG4105C59 Bacteria
COG2217 LUCA
KOiK17686
OMAiCAACGWL

Enzyme and pathway databases

BioCyciHPY:HP1503-MONOMER

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR021993 ATPase-cat-bd
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF12156 ATPase-cat_bd, 1 hit
PF00403 HMA, 1 hit
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS50846 HMA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO26033_HELPY
AccessioniPrimary (citable) accession number: O26033
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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