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UniProtKB - O25991 (MNME_HELPY)

Entry version 123 (29 Sep 2021)
Sequence version 1 (01 Jan 1998)
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Protein

tRNA modification GTPase MnmE

Gene

mnmE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.

UniRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

K+UniRule annotationNote: Binds 1 potassium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei32FormyltetrahydrofolateUniRule annotation1
Binding sitei89FormyltetrahydrofolateUniRule annotation1
Binding sitei128FormyltetrahydrofolateUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi234PotassiumUniRule annotation1
Metal bindingi238MagnesiumUniRule annotation1
Metal bindingi253Potassium; via carbonyl oxygenUniRule annotation1
Metal bindingi255Potassium; via carbonyl oxygenUniRule annotation1
Metal bindingi258PotassiumUniRule annotation1
Metal bindingi259MagnesiumUniRule annotation1
Binding sitei461FormyltetrahydrofolateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi234 – 239GTPUniRule annotation6
Nucleotide bindingi253 – 259GTPUniRule annotation7
Nucleotide bindingi278 – 281GTPUniRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processtRNA processing
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		HPY:HP1452-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA modification GTPase MnmEUniRule annotation (EC:3.6.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mnmEUniRule annotation
Synonyms:thdFUniRule annotation, trmEUniRule annotation
Ordered Locus Names:HP_1452
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001888821 – 461tRNA modification GTPase MnmEAdd BLAST461

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O25991

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

UniRule annotation

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-3365N

Protein interaction database and analysis system

More...IntActi		O25991, 3 interactors

Molecular INTeraction database

More...MINTi		O25991

STRING: functional protein association networks

More...STRINGi		85962.C694_07520

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O25991

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini224 – 387TrmE-type GAdd BLAST164

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0486, Bacteria

Identification of Orthologs from Complete Genome Data

More...OMAi		EFHCHGG

Database for complete collections of gene phylogenies

More...PhylomeDBi		O25991

Family and domain databases

Conserved Domains Database

More...CDDi		cd04164, trmE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.430, 1 hit
3.30.1360.120, 1 hit
3.40.50.300, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00379, GTPase_MnmE, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031168, G_TrmE
IPR006073, GTP-bd
IPR018948, GTP-bd_TrmE_N
IPR004520, GTPase_MnmE
IPR027368, MnmE_dom2
IPR025867, MnmE_helical
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR027266, TrmE/GcvT_dom1

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01926, MMR_HSR1, 1 hit
PF12631, MnmE_helical, 1 hit
PF10396, TrmE_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00450, mnmE_trmE_thdF, 1 hit
TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51709, G_TRME, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O25991-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNTSSSTTL TMNDTIAAIA TPLGKGAISI IKISGHNALN ILKQLTQKQD 
        60         70         80         90        100
FTPRYAYVHD IFSNGVLLDK ALVIYFKAPY SFTGEDVCEI QCHGSPLLAQ 
       110        120        130        140        150
NILQACLNLG ARLAKAGEFS KKAFLNHKMD LSEIEASVQL ILCEDESVLN 
       160        170        180        190        200
ALARQLKGEL KIFIEEARGN LLKLLASSEV LIDYSEEDIP SDFLDGVSLN 
       210        220        230        240        250
LEKQIASFKD LLDFSNAQKQ RNKGHALSIV GKPNAGKSSL LNAMLLEERA 
       260        270        280        290        300
LVSDIKGTTR DTIEEVIELK GHKVRLIDTA GIRESADKIE RLGIEKSLKS 
       310        320        330        340        350
LENCDIILGV FDLSKPLEKE DFNLIDTLNR AKKPCIVVLN KNDLAPKLEL 
       360        370        380        390        400
EILKSYLKIP YTLLETNTLN SKACLKDLSQ KISAFFPKLD TQNKLLLTSL 
       410        420        430        440        450
AQKIALENAI TELQNAKNHL ETLELFSYHI LSAIENLNLL TRPYETSQML 
       460 
DSMFSEFCLG K
Length:461
Mass (Da):51,170
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF7E5C4E3F66636D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08492.1

Protein sequence database of the Protein Information Resource

More...PIRi		D64701

NCBI Reference Sequences

More...RefSeqi		NP_208243.1, NC_000915.1
WP_000799508.1, NC_018939.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAD08492; AAD08492; HP_1452

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hpy:HP1452

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|85962.8.peg.1524

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08492.1
PIRiD64701
RefSeqiNP_208243.1, NC_000915.1
WP_000799508.1, NC_018939.1

3D structure databases

SMRiO25991
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-3365N
IntActiO25991, 3 interactors
MINTiO25991
STRINGi85962.C694_07520

Proteomic databases

PaxDbiO25991

Genome annotation databases

EnsemblBacteriaiAAD08492; AAD08492; HP_1452
KEGGihpy:HP1452
PATRICifig|85962.8.peg.1524

Phylogenomic databases

eggNOGiCOG0486, Bacteria
OMAiEFHCHGG
PhylomeDBiO25991

Enzyme and pathway databases

BioCyciHPY:HP1452-MONOMER

Family and domain databases

CDDicd04164, trmE, 1 hit
Gene3Di1.20.120.430, 1 hit
3.30.1360.120, 1 hit
3.40.50.300, 1 hit
HAMAPiMF_00379, GTPase_MnmE, 1 hit
InterProiView protein in InterPro
IPR031168, G_TrmE
IPR006073, GTP-bd
IPR018948, GTP-bd_TrmE_N
IPR004520, GTPase_MnmE
IPR027368, MnmE_dom2
IPR025867, MnmE_helical
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR027266, TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01926, MMR_HSR1, 1 hit
PF12631, MnmE_helical, 1 hit
PF10396, TrmE_N, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00450, mnmE_trmE_thdF, 1 hit
TIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51709, G_TRME, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMNME_HELPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O25991
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 1, 1998
Last modified: September 29, 2021
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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