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Entry version 100 (07 Oct 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
HPY:HP1450-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane protein insertase YidCUniRule annotation
Alternative name(s):
Foldase YidCUniRule annotation
Membrane integrase YidCUniRule annotation
Membrane protein YidCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yidCUniRule annotation
Ordered Locus Names:HP_1450
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalUniRule annotationAdd BLAST21
Transmembranei325 – 345HelicalUniRule annotationAdd BLAST21
Transmembranei348 – 368HelicalUniRule annotationAdd BLAST21
Transmembranei414 – 434HelicalUniRule annotationAdd BLAST21
Transmembranei449 – 469HelicalUniRule annotationAdd BLAST21
Transmembranei495 – 515HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001247191 – 547Membrane protein insertase YidCAdd BLAST547

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O25989

PRoteomics IDEntifications database

More...
PRIDEi
O25989

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.

UniRule annotation

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-3087N

Protein interaction database and analysis system

More...
IntActi
O25989, 3 interactors

Molecular INTeraction database

More...
MINTi
O25989

STRING: functional protein association networks

More...
STRINGi
85962.C694_07510

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
COG0706, Bacteria

KEGG Orthology (KO)

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KOi
K03217

Identification of Orthologs from Complete Genome Data

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OMAi
YKGMVSM

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01810, YidC_type1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019998, Membr_insert_YidC
IPR028055, Membr_insert_YidC/Oxa1_C
IPR028053, Membr_insert_YidC_N
IPR001708, YidC/ALB3/OXA1/COX18
IPR038210, YidC_periplasmic

The PANTHER Classification System

More...
PANTHERi
PTHR12428, PTHR12428, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02096, 60KD_IMP, 1 hit
PF14849, YidC_periplas, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01900, YIDCPROTEIN

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03593, yidC_nterm, 1 hit
TIGR03592, yidC_oxa1_cterm, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O25989-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKNNNNLRL ILAIALSFLF IALYSYFFQK PNKTTTQTTK QETTNNHTAT
60 70 80 90 100
SPNAPNAQHF STTQTTPQEN LLSTISFEHA RIEIDSLGRI KQVYLKDKKY
110 120 130 140 150
LTPKQKGFLE HVGHLFSSKE NAQPPLKELP LLAADKLKPL EVRFLDPTLN
160 170 180 190 200
NKAFNTPYSA SKTTLGPNEQ LVLTQDLGTL SIIKTLTFYD DLHYDLKIAF
210 220 230 240 250
KSPNNLIPSY VITNGYRPVA DLDSYTFSGV LLENSDKKIE KIEDKDAKEI
260 270 280 290 300
KRFSNTLFLS SVDRYFTTLL FTKDPQGFEA LIDSEIGTKN PLGFISLKNE
310 320 330 340 350
ANLHGYIGPK DYRSLKAISP MLTDVIEYGL ITFFAKGVFV LLDYLYQFVG
360 370 380 390 400
NWGWAIILLT IIVRIILYPL SYKGMVSMQK LKELAPKMKE LQEKYKGEPQ
410 420 430 440 450
KLQAHMMQLY KKHGANPLGG CLPLILQIPV FFAIYRVLYN AVELKSSEWI
460 470 480 490 500
LWIHDLSIMD PYFILPLLMG ASMYWHQSVT PNTMTDPMQA KIFKLLPLLF
510 520 530 540
TIFLITFPAG LVLYWTTNNI LSVLQQLIIN KVLENKKRMH AQNKKEH
Length:547
Mass (Da):62,584
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E5D32C3D3051F93
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08491.1

Protein sequence database of the Protein Information Resource

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PIRi
B64701

NCBI Reference Sequences

More...
RefSeqi
NP_208241.1, NC_000915.1
WP_000360153.1, NC_018939.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD08491; AAD08491; HP_1450

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
heo:C694_07510
hpy:HP1450

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|85962.47.peg.1559

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08491.1
PIRiB64701
RefSeqiNP_208241.1, NC_000915.1
WP_000360153.1, NC_018939.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-3087N
IntActiO25989, 3 interactors
MINTiO25989
STRINGi85962.C694_07510

Proteomic databases

PaxDbiO25989
PRIDEiO25989

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
899843

Genome annotation databases

EnsemblBacteriaiAAD08491; AAD08491; HP_1450
KEGGiheo:C694_07510
hpy:HP1450
PATRICifig|85962.47.peg.1559

Phylogenomic databases

eggNOGiCOG0706, Bacteria
KOiK03217
OMAiYKGMVSM

Enzyme and pathway databases

BioCyciHPY:HP1450-MONOMER

Family and domain databases

HAMAPiMF_01810, YidC_type1, 1 hit
InterProiView protein in InterPro
IPR019998, Membr_insert_YidC
IPR028055, Membr_insert_YidC/Oxa1_C
IPR028053, Membr_insert_YidC_N
IPR001708, YidC/ALB3/OXA1/COX18
IPR038210, YidC_periplasmic
PANTHERiPTHR12428, PTHR12428, 1 hit
PfamiView protein in Pfam
PF02096, 60KD_IMP, 1 hit
PF14849, YidC_periplas, 1 hit
PRINTSiPR01900, YIDCPROTEIN
TIGRFAMsiTIGR03593, yidC_nterm, 1 hit
TIGR03592, yidC_oxa1_cterm, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYIDC_HELPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O25989
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: January 1, 1998
Last modified: October 7, 2020
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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