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UniProtKB - O25899 (TONB_HELPY)
Protein
Protein TonB
Gene
tonB
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
By similarityGO - Molecular functioni
- energy transducer activity Source: GO_Central
- siderophore transmembrane transporter activity Source: InterPro
GO - Biological processi
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Protein TonB |
Gene namesi | Name:tonB Ordered Locus Names:HP_1341 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane By similarity; Single-pass membrane protein By similarity; Periplasmic side By similarity
Plasma Membrane
- plasma membrane protein complex Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- outer membrane-bounded periplasmic space Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 14 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 15 – 35 | Helical; Signal-anchorSequence analysisAdd BLAST | 21 | |
Topological domaini | 36 – 285 | PeriplasmicSequence analysisAdd BLAST | 250 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000196198 | 1 – 285 | Protein TonBAdd BLAST | 285 |
Proteomic databases
PaxDbi | O25899 |
Interactioni
Protein-protein interaction databases
IntActi | O25899, 1 interactor |
MINTi | O25899 |
STRINGi | 85962.C694_06920 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | O25899 |
SMRi | O25899 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 55 – 187 | DisorderedSequence analysisAdd BLAST | 133 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 69 – 97 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 109 – 178 | Basic and acidic residuesSequence analysisAdd BLAST | 70 |
Sequence similaritiesi
Belongs to the TonB family.Curated
Keywords - Domaini
Repeat, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0810, Bacteria |
OMAi | SEAQAYN |
Family and domain databases
InterProi | View protein in InterPro IPR003538, TonB IPR006260, TonB/TolA_C IPR037682, TonB_C |
Pfami | View protein in Pfam PF03544, TonB_C, 1 hit |
PRINTSi | PR01374, TONBPROTEIN |
TIGRFAMsi | TIGR01352, tonB_Cterm, 1 hit |
i Sequence
Sequence statusi: Complete.
O25899-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKISPSPRKL SKVSTSVSFL ISFALYAIGF GYFLLREDAP EPLAQAGTTK
60 70 80 90 100
VTMSLASINT NSNTKTNAES AKPKEEPKEK PKKEEPKKEE PKKEVTKPKP
110 120 130 140 150
KPKPKPKPKP KPKPEPKPEP KPEPKPEPKV EEVKKEEPKE EPKKEEAKEE
160 170 180 190 200
AKEKSAPKQV TTKDIVKEKD KQEESNKTSE GATSEAQAYN PGVSNEFLMK
210 220 230 240 250
IQTAISSKNR YPKMAQIRGI EGEVLVSFTI NADGSVTDIK VVKSNTTDIL
260 270 280
NHAALEAIKS AAHLFPKPEE TVHLKIPIAY SLKED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD08383.1 |
PIRi | E64687 |
RefSeqi | NP_208133.1, NC_000915.1 WP_000703807.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD08383; AAD08383; HP_1341 |
KEGGi | hpy:HP_1341 |
PATRICi | fig|85962.47.peg.1436 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD08383.1 |
PIRi | E64687 |
RefSeqi | NP_208133.1, NC_000915.1 WP_000703807.1, NC_018939.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5LW8 | NMR | - | A | 194-285 | [»] | |
6SLY | NMR | - | A | 179-285 | [»] | |
BMRBi | O25899 | |||||
SMRi | O25899 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | O25899, 1 interactor |
MINTi | O25899 |
STRINGi | 85962.C694_06920 |
Proteomic databases
PaxDbi | O25899 |
Genome annotation databases
EnsemblBacteriai | AAD08383; AAD08383; HP_1341 |
KEGGi | hpy:HP_1341 |
PATRICi | fig|85962.47.peg.1436 |
Phylogenomic databases
eggNOGi | COG0810, Bacteria |
OMAi | SEAQAYN |
Family and domain databases
InterProi | View protein in InterPro IPR003538, TonB IPR006260, TonB/TolA_C IPR037682, TonB_C |
Pfami | View protein in Pfam PF03544, TonB_C, 1 hit |
PRINTSi | PR01374, TONBPROTEIN |
TIGRFAMsi | TIGR01352, tonB_Cterm, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TONB_HELPY | |
Accessioni | O25899Primary (citable) accession number: O25899 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families