Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein translocase subunit SecY

Gene

secY

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciHPY:HP1300-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:HP_1300
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalUniRule annotationAdd BLAST21
Transmembranei61 – 81HelicalUniRule annotationAdd BLAST21
Transmembranei104 – 124HelicalUniRule annotationAdd BLAST21
Transmembranei141 – 161HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21
Transmembranei203 – 223HelicalUniRule annotationAdd BLAST21
Transmembranei257 – 277HelicalUniRule annotationAdd BLAST21
Transmembranei300 – 320HelicalUniRule annotationAdd BLAST21
Transmembranei355 – 375HelicalUniRule annotationAdd BLAST21
Transmembranei377 – 397HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317251 – 420Protein translocase subunit SecYAdd BLAST420

Proteomic databases

PaxDbiO25879

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3770N
IntActiO25879, 1 interactor
MINTiO25879
STRINGi85962.HP1300

Structurei

3D structure databases

ProteinModelPortaliO25879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG Bacteria
COG0201 LUCA
KOiK03076
OMAiQTYVISQ

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
HAMAPiMF_01465 SecY, 1 hit
InterProiView protein in InterPro
IPR026593 SecY
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit

Sequencei

Sequence statusi: Complete.

O25879-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKAIASKIL ITLGFLFLYR VLAYIPIPGV DLAAIKAFFD SNSNNALGLF
60 70 80 90 100
NMFSGNAVSR LSIISLGIMP YITSSIIMEL LSATFPNLAK MKKERDGMQK
110 120 130 140 150
YMQIVRYLTI LITLIQAVSV SVGLRSISGG ANGAIMIDMQ VFMIVSAFSM
160 170 180 190 200
LTGTMLLMWI GEQITQRGVG NGISLIIFAG IVSGIPSAIS GTFNLVNTGV
210 220 230 240 250
INILMLIGIV LIVLATIFAI IYVELAERRI PISYARKVVM QNQNKRIMNY
260 270 280 290 300
IPIKLNLSGV IPPIFASALL VFPSTILQQA TSNKTLQAVA DFLSPQGYAY
310 320 330 340 350
NILMFLLIIF FAYFYSSIVF NSKDIADNLR RNGGYIPGLR PGEGTSSFLN
360 370 380 390 400
SVASKLTLWG SLYLALISTV PWILVKAMGV PFYFGGTAVL IVVQVAIDTM
410 420
KKIEAQIYMS KYKTLSAVGF
Length:420
Mass (Da):45,829
Last modified:January 1, 1998 - v1
Checksum:i9FD337091D905F9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08341.1
PIRiD64682
RefSeqiNP_208092.1, NC_000915.1
WP_001030187.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08341; AAD08341; HP_1300
GeneIDi899085
KEGGiheo:C694_06715
hpy:HP1300
PATRICifig|85962.47.peg.1394

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08341.1
PIRiD64682
RefSeqiNP_208092.1, NC_000915.1
WP_001030187.1, NC_018939.1

3D structure databases

ProteinModelPortaliO25879
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3770N
IntActiO25879, 1 interactor
MINTiO25879
STRINGi85962.HP1300

Proteomic databases

PaxDbiO25879

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08341; AAD08341; HP_1300
GeneIDi899085
KEGGiheo:C694_06715
hpy:HP1300
PATRICifig|85962.47.peg.1394

Phylogenomic databases

eggNOGiENOG4105CGG Bacteria
COG0201 LUCA
KOiK03076
OMAiQTYVISQ

Enzyme and pathway databases

BioCyciHPY:HP1300-MONOMER

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
HAMAPiMF_01465 SecY, 1 hit
InterProiView protein in InterPro
IPR026593 SecY
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSECY_HELPY
AccessioniPrimary (citable) accession number: O25879
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: October 10, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again