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UniProtKB - O25867 (TRPC_HELPY)
Protein
Tryptophan biosynthesis protein TrpCF
Gene
trpC
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
By similarityCatalytic activityi
- EC:5.3.1.24
- 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+ = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2OEC:4.1.1.48
: L-tryptophan biosynthesis Pathwayi
This protein is involved in step 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate. This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- indole-3-glycerol-phosphate synthase activity Source: GO_Central
- phosphoribosylanthranilate isomerase activity Source: GO_Central
GO - Biological processi
- tryptophan biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Decarboxylase, Isomerase, Lyase, Multifunctional enzyme |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00035;UER00042 UPA00035;UER00043 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:trpC Ordered Locus Names:HP_1279 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000154280 | 1 – 452 | Tryptophan biosynthesis protein TrpCFAdd BLAST | 452 |
Proteomic databases
PaxDbi | O25867 |
Interactioni
Protein-protein interaction databases
IntActi | O25867, 2 interactors |
MINTi | O25867 |
STRINGi | 85962.C694_06610 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 253 | Indole-3-glycerol phosphate synthaseAdd BLAST | 253 | |
Regioni | 254 – 448 | N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST | 195 |
Sequence similaritiesi
In the N-terminal section; belongs to the TrpC family.Curated
In the C-terminal section; belongs to the TrpF family.Curated
Phylogenomic databases
eggNOGi | COG0134, Bacteria COG0135, Bacteria |
OMAi | YDIIGIN |
PhylomeDBi | O25867 |
Family and domain databases
CDDi | cd00331, IGPS, 1 hit cd00405, PRAI, 1 hit |
Gene3Di | 3.20.20.70, 2 hits |
HAMAPi | MF_00134_B, IGPS_B, 1 hit MF_00135, PRAI, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR045186, Indole-3-glycerol_P_synth IPR013798, Indole-3-glycerol_P_synth_dom IPR001468, Indole-3-GlycerolPSynthase_CS IPR001240, PRAI_dom IPR011060, RibuloseP-bd_barrel |
PANTHERi | PTHR22854, PTHR22854, 1 hit |
Pfami | View protein in Pfam PF00218, IGPS, 1 hit PF00697, PRAI, 1 hit |
SUPFAMi | SSF51366, SSF51366, 2 hits |
PROSITEi | View protein in PROSITE PS00614, IGPS, 1 hit |
i Sequence
Sequence statusi: Complete.
O25867-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSVLENILK DKLLEVSDLK KNHALPININ PSDRDFKKAL LEKKTSFILE
60 70 80 90 100
CKKASPSKGL IRKDFDLLKI TKTYEKFASC ISVLADSKYF LGSYENIKIV
110 120 130 140 150
SQHSTKPILC KDFIIDAFQI KLARMMGANA VLLMLSVLDD KNYLELFNLA
160 170 180 190 200
KSLNMSVLTE VSNQQEIEHL LKLQYDIIGI NNRDLHTLKT DINHTLKLRP
210 220 230 240 250
LLPKDALIIS ESGIYSHAQI KALAPYVNGF LVGSSLMKEK DLKKACIKLI
260 270 280 290 300
LGENKVCGLT RIKDAKAVYK NHFIYGGLIF EKSSPRYIKP KEALKITKAV
310 320 330 340 350
KKLDFVGVFV KDSIKKIQKI VKKLDLKAVQ LYGYSQKEIA QLKKALPKTC
360 370 380 390 400
AIWQVISVMS AKDLVPKTKE ASLILYDTKG DKMGGNGVSF DWEILENVKT
410 420 430 440 450
PFMLAGGLNL DNIQKALKVE ALGLDFNSGL EISPGIKNKD KIKRLARILR
EY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD08324.1 |
PIRi | G64679 |
RefSeqi | NP_208071.1, NC_000915.1 WP_001141446.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD08324; AAD08324; HP_1279 |
KEGGi | hpy:HP_1279 |
PATRICi | fig|85962.47.peg.1372 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD08324.1 |
PIRi | G64679 |
RefSeqi | NP_208071.1, NC_000915.1 WP_001141446.1, NC_018939.1 |
3D structure databases
AlphaFoldDBi | O25867 |
SMRi | O25867 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | O25867, 2 interactors |
MINTi | O25867 |
STRINGi | 85962.C694_06610 |
Proteomic databases
PaxDbi | O25867 |
Genome annotation databases
EnsemblBacteriai | AAD08324; AAD08324; HP_1279 |
KEGGi | hpy:HP_1279 |
PATRICi | fig|85962.47.peg.1372 |
Phylogenomic databases
eggNOGi | COG0134, Bacteria COG0135, Bacteria |
OMAi | YDIIGIN |
PhylomeDBi | O25867 |
Enzyme and pathway databases
UniPathwayi | UPA00035;UER00042 UPA00035;UER00043 |
Family and domain databases
CDDi | cd00331, IGPS, 1 hit cd00405, PRAI, 1 hit |
Gene3Di | 3.20.20.70, 2 hits |
HAMAPi | MF_00134_B, IGPS_B, 1 hit MF_00135, PRAI, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR045186, Indole-3-glycerol_P_synth IPR013798, Indole-3-glycerol_P_synth_dom IPR001468, Indole-3-GlycerolPSynthase_CS IPR001240, PRAI_dom IPR011060, RibuloseP-bd_barrel |
PANTHERi | PTHR22854, PTHR22854, 1 hit |
Pfami | View protein in Pfam PF00218, IGPS, 1 hit PF00697, PRAI, 1 hit |
SUPFAMi | SSF51366, SSF51366, 2 hits |
PROSITEi | View protein in PROSITE PS00614, IGPS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRPC_HELPY | |
Accessioni | O25867Primary (citable) accession number: O25867 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families