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Entry version 138 (29 Sep 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Bifunctional DNA-directed RNA polymerase subunit beta-beta'

Gene

rpoBC

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

UniRule annotation

Miscellaneous

Fusion of rpoB and rpoC occurs naturally in Helicobacter species and at least some Wolbachia; the protein has been artificially split in two in H.pylori. The split protein seems to function normally.1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1449Zinc 1UniRule annotation1
Metal bindingi1451Zinc 1UniRule annotation1
Metal bindingi1465Zinc 1UniRule annotation1
Metal bindingi1468Zinc 1UniRule annotation1
Metal bindingi1849MagnesiumUniRule annotation1
Metal bindingi1851MagnesiumUniRule annotation1
Metal bindingi1853MagnesiumUniRule annotation1
Metal bindingi2179Zinc 2UniRule annotation1
Metal bindingi2253Zinc 2UniRule annotation1
Metal bindingi2260Zinc 2UniRule annotation1
Metal bindingi2263Zinc 2UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription
LigandMagnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
HPY:HP1198-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional DNA-directed RNA polymerase subunit beta-beta' (EC:2.7.7.6UniRule annotation)
Including the following 2 domains:
DNA-directed RNA polymerase subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
DNA-directed RNA polymerase subunit beta'UniRule annotation
Alternative name(s):
RNA polymerase subunit beta'UniRule annotation
Transcriptase subunit beta'UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpoBC
Ordered Locus Names:HP_1198
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000480051 – 2890Bifunctional DNA-directed RNA polymerase subunit beta-beta'Add BLAST2890

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.1 Publication

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O25806

PRoteomics IDEntifications database

More...
PRIDEi
O25806

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta/beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

UniRule annotation

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-3257N

Protein interaction database and analysis system

More...
IntActi
O25806, 35 interactors

Molecular INTeraction database

More...
MINTi
O25806

STRING: functional protein association networks

More...
STRINGi
85962.C694_06195

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O25806

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1377DNA-directed RNA polymerase subunit betaAdd BLAST1377
Regioni1384 – 2890DNA-directed RNA polymerase subunit beta'Add BLAST1507

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the RNA polymerase beta chain family.Curated
In the C-terminal section; belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0085, Bacteria
COG0086, Bacteria

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTEKIDD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O25806

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00653, RNA_pol_B_RPB2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.30, 1 hit
1.10.274.100, 2 hits
2.30.150.10, 1 hit
2.40.270.10, 1 hit
2.40.50.150, 1 hit
3.90.1110.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01321, RNApol_bact_RpoB, 1 hit
MF_01322, RNApol_bact_RpoC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042107, DNA-dir_RNA_pol_bsu_ext_1_sf
IPR019462, DNA-dir_RNA_pol_bsu_external_1
IPR015712, DNA-dir_RNA_pol_su2
IPR007120, DNA-dir_RNAP_su2_dom
IPR037033, DNA-dir_RNAP_su2_hyb_sf
IPR012754, DNA-dir_RpoC_beta_prime
IPR000722, RNA_pol_asu
IPR010243, RNA_pol_bsu_bac
IPR007121, RNA_pol_bsu_CS
IPR007644, RNA_pol_bsu_protrusion
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR007642, RNA_pol_Rpb2_2
IPR037034, RNA_pol_Rpb2_2_sf
IPR007645, RNA_pol_Rpb2_3
IPR007641, RNA_pol_Rpb2_7
IPR014724, RNA_pol_RPB2_OB-fold
IPR038120, Rpb1_funnel_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
PF04563, RNA_pol_Rpb2_1, 1 hit
PF04561, RNA_pol_Rpb2_2, 2 hits
PF04565, RNA_pol_Rpb2_3, 1 hit
PF10385, RNA_pol_Rpb2_45, 1 hit
PF00562, RNA_pol_Rpb2_6, 1 hit
PF04560, RNA_pol_Rpb2_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00663, RPOLA_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02013, rpoB, 1 hit
TIGR02386, rpoC_TIGR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01166, RNA_POL_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O25806-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKKIPLKNR LRADFTKTPT DLEVPNLLLL QRDSYDSFLY SKEGKESGIE
60 70 80 90 100
KVFKSIFPIQ DEHNRITLEY AGCEFGKSKY TVREAMERGI TYSIPLKIKV
110 120 130 140 150
RLILWEKDTK SGEKNGIKDI KEQSIFIREI PLMTERTSFI INGVERVVVN
160 170 180 190 200
QLHRSPGVIF KEEESSTSLN KLIYTGQIIP DRGSWLYFEY DSKDVLYARI
210 220 230 240 250
NKRRKVPVTI LFRAMDYQKQ DIIKMFYPLV KVRYENDKYL IPFASLDANQ
260 270 280 290 300
RMEFDLKDPQ GKVILLAGKK LTSRKIKELK ENHLEWVEYP MDILLNRHLA
310 320 330 340 350
EPVMVGKEVL LDMLTQLDKN KLEKIHDLGV QEFVIINDLA LGHDASIIQS
360 370 380 390 400
FSADSESLKL LKQTEKIDDE NALAAIRIHK VMKPGDPVTT EVAKQFVKKL
410 420 430 440 450
FFDPERYDLT MVGRMKMNHK LGLHVPDYIT TLTHEDIITT VKYLMKIKNN
460 470 480 490 500
QGKIDDRDHL GNRRIRAVGE LLANELHSGL VKMQKTIKDK LTTMSGAFDS
510 520 530 540 550
LMPHDLVNSK MITSTIMEFF MGGQLSQFMD QTNPLSEVTH KRRLSALGEG
560 570 580 590 600
GLVKDRVGFE ARDVHPTHYG RICPIETPEG QNIGLINTLS TFTRVNDLGF
610 620 630 640 650
IEAPYKKVVD GKVVGETIYL TAIQEDSHII APASTPIDEE GNILGDLIET
660 670 680 690 700
RVEGEIVLNE KSKVTLMDLS SSMLVGVAAS LIPFLEHDDA NRALMGTNMQ
710 720 730 740 750
RQAVPLLRSD APIVGTGIEK IIARDSWGAI KANRAGVVEK IDSKNIYILG
760 770 780 790 800
ESKEEAYIDA YSLQKNLRTN QNTSFNQVPI VKVGDKVGAG QIIADGPSMD
810 820 830 840 850
RGELALGKNV RVAFMPWNGY NFEDAIVVSE CITKDDIFTS THIYEKEVDA
860 870 880 890 900
RELKHGVEEF TADIPDVKEE ALAHLDESGI VKVGTYVSAG MILVGKTSPK
910 920 930 940 950
GEIKSTPEER LLRAIFGDKA GHVVNKSLYC PPSLEGTVID VKVFTKKGYE
960 970 980 990 1000
KDARVLSAYE EEKAKLDMEH FDRLTMLNRE ELLRVSSLLS QAILEEPFSH
1010 1020 1030 1040 1050
NGKDYKEGDQ IPKEEIASIN RFTLASLVKK YSKEVQNHYE ITKNNFLEQK
1060 1070 1080 1090 1100
KVLGEEHEEK LSILEKDDIL PNGVIKKVKL YIATKRKLKV GDKMAGRHGN
1110 1120 1130 1140 1150
KGIVSNIVPV ADMPYTADGE PVDIVLNPLG VPSRMNIGQI LEMHLGLVGK
1160 1170 1180 1190 1200
EFGKQIARML EDKTKDFAKE LRAKMLEIAN AINEKDPLTI HALENCSDEE
1210 1220 1230 1240 1250
LLEYAKDWSK GVKMAIPVFE GISQEKFYKL FELAKIAMDG KMDLYDGRTG
1260 1270 1280 1290 1300
EKMRERVNVG YMYMIKLHHL VDEKVHARST GPYSLVTHQP VGGKALFGGQ
1310 1320 1330 1340 1350
RFGEMEVWAL EAYGAAHTLK EMLTIKSDDI RGRENAYRAI AKGEQVGESE
1360 1370 1380 1390 1400
IPETFYVLTK ELQSLALDIN IFGDDVDEDG APKPIVIKED DRPKDFSSFQ
1410 1420 1430 1440 1450
LTLASPEKIH SWSYGEVKKP ETINYRTLKP ERDGLFCMKI FGPTKDYECL
1460 1470 1480 1490 1500
CGKYKKPRFK DIGTCEKCGV AITHSKVRRF RMGHIELATP VAHIWYVNSL
1510 1520 1530 1540 1550
PSRIGTLLGV KMKDLERVLY YEAYIVKEPG EAAYDNEGTK LVMKYDILNE
1560 1570 1580 1590 1600
EQYQNISRRY EDRGFVAQMG GEAIKDLLEE IDLITLLQSL KEEVKDTNSD
1610 1620 1630 1640 1650
AKKKKLIKRL KVVESFLNSG NRPEWMMLTV LPVLPPDLRP LVALDGGKFA
1660 1670 1680 1690 1700
VSDVNELYRR VINRNQRLKR LMELGAPEII VRNEKRMLQE AVDVLFDNGR
1710 1720 1730 1740 1750
STNAVKGANK RPLKSLSEII KGKQGRFRQN LLGKRVDFSG RSVIVVGPNL
1760 1770 1780 1790 1800
KMDECGLPKN MALELFKPHL LSKLEERGYA TTLKQAKRMI EQKSNEVWEC
1810 1820 1830 1840 1850
LQEITEGYPV LLNRAPTLHK QSIQAFHPKL IDGKAIQLHP LVCSAFNADF
1860 1870 1880 1890 1900
DGDQMAVHVP LSQEAIAECK VLMLSSMNIL LPASGKAVAI PSQDMVLGLY
1910 1920 1930 1940 1950
YLSLEKSGVK GEHKLFSSVN EIITAIDTKE LDIHAKIRVL DQGNIIATSA
1960 1970 1980 1990 2000
GRMIIKSILP DFIPTDLWNR PMKKKDIGVL VDYVHKVGGI GITATFLDNL
2010 2020 2030 2040 2050
KTLGFRYATK AGISISMEDI ITPKDKQKMV EKAKVEVKKI QQQYDQGLLT
2060 2070 2080 2090 2100
DQERYNKIID TWTEVNDKMS KEMMTAIAQD KEGFNSIYMM ADSGARGSAA
2110 2120 2130 2140 2150
QIRQLSAMRG LMTKPDGSII ETPIISNFKE GLNVLEYFNS THGARKGLAD
2160 2170 2180 2190 2200
TALKTANAGY LTRKLIDVSQ NVKVVSDDCG THEGIEITDI AVGSELIEPL
2210 2220 2230 2240 2250
EERIFGRVLL EDVIDPITNE ILLYADTLID EEGAKKVVEA GIKSITIRTP
2260 2270 2280 2290 2300
VTCKAPKGVC AKCYGLNLGE GKMSYPGEAV GVVAAQSIGE PGTQLTLRTF
2310 2320 2330 2340 2350
HVGGTASRSQ DEREIVASKE GFVRFYNLRT YTNKEGKNII ANRRNASILV
2360 2370 2380 2390 2400
VEPKIKAPFD GELRIETVYE EVVVSVKNGD QEAKFVLRRS DIVKPSELAG
2410 2420 2430 2440 2450
VGGKIEGKVY LPYASGHKVH KGGSIADIIQ EGWNVPNRIP YASELLVKDN
2460 2470 2480 2490 2500
DPIAQDVYAK EKGVIKYYVL EANHLERTHG IKKGDMVSEK GLFAVIADDN
2510 2520 2530 2540 2550
GREAARHYIA RGSEILIDDN SEVSTNSVIS KPTTNTFKTI ATWDPYNTPI
2560 2570 2580 2590 2600
IADFKGKVGF VDVIAGVTVA EKEDENTGIT SLVVNDYIPS GYKPSLFLEG
2610 2620 2630 2640 2650
ANGEEMRYFL EPKTSIAISD GSSVEQAEVL AKIPKATVKS RDITGGLPRV
2660 2670 2680 2690 2700
SELFEARKPK PKDVAILSEV DGIVSFGKPI RNKEHIIVTS KDGRSMDYFV
2710 2720 2730 2740 2750
DKGKQILVHA DEFVHAGEAM TDGVISSHDI LRISGEKELY KYIVSEVQQV
2760 2770 2780 2790 2800
YRRQGVSIAD KHIEIIVSQM LRQVRILDSG DSKFIEGDLV SKKLFKEENA
2810 2820 2830 2840 2850
RVIALKGEPA IAEPVLLGIT RAAIGSDSII SAASFQETTK VLTEASIAMK
2860 2870 2880 2890
KDFLEDLKEN VVLGRMIPVG TGMYKNKKIV LRALEDNSKF
Length:2,890
Mass (Da):323,575
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B733A607AF07C98
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08242.1
AF068776 Genomic DNA Translation: AAC25190.1
AF068254 Genomic DNA Translation: AAC25712.1
AF068774 Genomic DNA Translation: AAC25188.1
AF068775 Genomic DNA Translation: AAC25189.1

Protein sequence database of the Protein Information Resource

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PIRi
F64669

NCBI Reference Sequences

More...
RefSeqi
NP_207989.1, NC_000915.1
WP_000037869.1, NC_018939.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD08242; AAD08242; HP_1198

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpy:HP1198

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|85962.47.peg.1287

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08242.1
AF068776 Genomic DNA Translation: AAC25190.1
AF068254 Genomic DNA Translation: AAC25712.1
AF068774 Genomic DNA Translation: AAC25188.1
AF068775 Genomic DNA Translation: AAC25189.1
PIRiF64669
RefSeqiNP_207989.1, NC_000915.1
WP_000037869.1, NC_018939.1

3D structure databases

SMRiO25806
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-3257N
IntActiO25806, 35 interactors
MINTiO25806
STRINGi85962.C694_06195

Proteomic databases

PaxDbiO25806
PRIDEiO25806

Genome annotation databases

EnsemblBacteriaiAAD08242; AAD08242; HP_1198
KEGGihpy:HP1198
PATRICifig|85962.47.peg.1287

Phylogenomic databases

eggNOGiCOG0085, Bacteria
COG0086, Bacteria
OMAiQTEKIDD
PhylomeDBiO25806

Enzyme and pathway databases

BioCyciHPY:HP1198-MONOMER

Family and domain databases

CDDicd00653, RNA_pol_B_RPB2, 1 hit
Gene3Di1.10.132.30, 1 hit
1.10.274.100, 2 hits
2.30.150.10, 1 hit
2.40.270.10, 1 hit
2.40.50.150, 1 hit
3.90.1110.10, 1 hit
HAMAPiMF_01321, RNApol_bact_RpoB, 1 hit
MF_01322, RNApol_bact_RpoC, 1 hit
InterProiView protein in InterPro
IPR042107, DNA-dir_RNA_pol_bsu_ext_1_sf
IPR019462, DNA-dir_RNA_pol_bsu_external_1
IPR015712, DNA-dir_RNA_pol_su2
IPR007120, DNA-dir_RNAP_su2_dom
IPR037033, DNA-dir_RNAP_su2_hyb_sf
IPR012754, DNA-dir_RpoC_beta_prime
IPR000722, RNA_pol_asu
IPR010243, RNA_pol_bsu_bac
IPR007121, RNA_pol_bsu_CS
IPR007644, RNA_pol_bsu_protrusion
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR007642, RNA_pol_Rpb2_2
IPR037034, RNA_pol_Rpb2_2_sf
IPR007645, RNA_pol_Rpb2_3
IPR007641, RNA_pol_Rpb2_7
IPR014724, RNA_pol_RPB2_OB-fold
IPR038120, Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
PF04563, RNA_pol_Rpb2_1, 1 hit
PF04561, RNA_pol_Rpb2_2, 2 hits
PF04565, RNA_pol_Rpb2_3, 1 hit
PF10385, RNA_pol_Rpb2_45, 1 hit
PF00562, RNA_pol_Rpb2_6, 1 hit
PF04560, RNA_pol_Rpb2_7, 1 hit
SMARTiView protein in SMART
SM00663, RPOLA_N, 1 hit
TIGRFAMsiTIGR02013, rpoB, 1 hit
TIGR02386, rpoC_TIGR, 1 hit
PROSITEiView protein in PROSITE
PS01166, RNA_POL_BETA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOBC_HELPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O25806
Secondary accession number(s): Q9R3R4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 1, 1998
Last modified: September 29, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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