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UniProtKB - O25711 (ATGTP_HELPY)
Protein
ATP/GTP phosphatase
Gene
HP_1079
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Has nucleotide phosphatase activity toward ATP and GTP, but not toward CTP, TTP and ADP.
1 PublicationCatalytic activityi
Kineticsi
kcat is 9.3 min(-1) and 0.57 min(-1) with ATP and GTP as substrate, respectively.
- KM=1.02 mM for ATP1 Publication
- KM=0.58 mM for GTP1 Publication
pH dependencei
Optimum pH is 6.0.1 Publication
Temperature dependencei
Optimum temperature is 45 degrees Celsius.1 Publication
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- GTPase activity Source: RHEA
- GTP binding Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Ligand | ATP-binding, GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
SABIO-RKi | O25711 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Ordered Locus Names:HP_1079, C694_05575 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000424563 | 1 – 370 | ATP/GTP phosphataseAdd BLAST | 370 |
Proteomic databases
PaxDbi | O25711 |
Interactioni
Protein-protein interaction databases
DIPi | DIP-3250N |
IntActi | O25711, 1 interactor |
MINTi | O25711 |
STRINGi | 85962.C694_05575 |
Structurei
3D structure databases
AlphaFoldDBi | O25711 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Phylogenomic databases
eggNOGi | COG1106, Bacteria |
HOGENOMi | CLU_063816_0_0_7 |
OMAi | FMTTHSQ |
PhylomeDBi | O25711 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003959, ATPase_AAA_core IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13304, AAA_21, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
i Sequence
Sequence statusi: Complete.
O25711-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIQSVRIKNF KNFKNTKIDG FTKLNIITGQ NNAGKSNLLE ALYYLVGKSM
60 70 80 90 100
HPCTNVLEIY DNIRKEPLTS ESKSLMFYGL DTKEEIQIVT TLDNNQTLDL
110 120 130 140 150
QIKFIASENQ KVIESQIIPT AEQTQMSSQL NFTLKKNNEE IYNDHLNIAK
160 170 180 190 200
VPNFPPIPNQ SGYNRQFKNF DSNQLQKLLP FESAVIIPSD VVYRQAHMIQ
210 220 230 240 250
AVSKICSNNQ LEEELNKHLN QFDNNIQAIS FNTNNQLKLK VKDIKEKVPL
260 270 280 290 300
SVFGDGLKKY LHIVSAFMAD NAKTIYIDEV ENGLHFSRMR LLLKNTIDFI
310 320 330 340 350
NNNKDGNLQV FMTTHSQEFI EILDQVIREK DFAHQTKLFC LKQDDQYVIP
360 370
RTYYGENLEY YFENEENLFG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD08125.1 CP003904 Genomic DNA Translation: AFV42292.1 |
PIRi | G64654 |
RefSeqi | NP_207870.1, NC_000915.1 WP_000616490.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD08125; AAD08125; HP_1079 |
KEGGi | heo:C694_05575 hpy:HP_1079 |
PATRICi | fig|85962.47.peg.1158 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD08125.1 CP003904 Genomic DNA Translation: AFV42292.1 |
PIRi | G64654 |
RefSeqi | NP_207870.1, NC_000915.1 WP_000616490.1, NC_018939.1 |
3D structure databases
AlphaFoldDBi | O25711 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
DIPi | DIP-3250N |
IntActi | O25711, 1 interactor |
MINTi | O25711 |
STRINGi | 85962.C694_05575 |
Proteomic databases
PaxDbi | O25711 |
Protocols and materials databases
DNASUi | 899615 |
Genome annotation databases
EnsemblBacteriai | AAD08125; AAD08125; HP_1079 |
KEGGi | heo:C694_05575 hpy:HP_1079 |
PATRICi | fig|85962.47.peg.1158 |
Phylogenomic databases
eggNOGi | COG1106, Bacteria |
HOGENOMi | CLU_063816_0_0_7 |
OMAi | FMTTHSQ |
PhylomeDBi | O25711 |
Enzyme and pathway databases
SABIO-RKi | O25711 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003959, ATPase_AAA_core IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13304, AAA_21, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ATGTP_HELPY | |
Accessioni | O25711Primary (citable) accession number: O25711 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 11, 2013 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |