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Entry version 84 (02 Jun 2021)
Sequence version 1 (01 Jan 1998)
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Protein
Submitted name:

Conserved hypothetical secreted protein

Gene

HP_1075

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi46Calcium 1Combined sources1
Metal bindingi46Calcium 2Combined sources1
Metal bindingi49Calcium 1Combined sources1
Metal bindingi49Calcium 2Combined sources1
Metal bindingi62Calcium 3; via pros nitrogenCombined sources1
Metal bindingi128Calcium 1; via pros nitrogenCombined sources1
Metal bindingi173Calcium 4Combined sources1
Metal bindingi176Calcium 4Combined sources1
Metal bindingi184Zinc 1; via pros nitrogenCombined sources1
Metal bindingi187Zinc 1Combined sources1
Metal bindingi254Calcium 3Combined sources1
Metal bindingi320Zinc 2Combined sources1
Metal bindingi321Zinc 2Combined sources1
Metal bindingi347Zinc 2Combined sources1
Metal bindingi382Calcium 5Combined sources1
Metal bindingi383Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi386Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi396Calcium 5Combined sources1
Metal bindingi398Calcium 4; via carbonyl oxygenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumCombined sources, Metal-bindingCombined sources, ZincCombined sources

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M99.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Conserved hypothetical secreted proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:HP_1075Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O25708

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-3761N

Protein interaction database and analysis system

More...
IntActi
O25708, 1 interactor

Molecular INTeraction database

More...
MINTi
O25708

STRING: functional protein association networks

More...
STRINGi
85962.C694_05555

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O25708

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 267Peptidase_M99InterPro annotationAdd BLAST267
Domaini268 – 340Peptidase_M99_mInterPro annotationAdd BLAST73
Domaini341 – 438Peptidase_M99_CInterPro annotationAdd BLAST98

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3608, Bacteria

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFYAINQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033398, M99_beta-barrel
IPR033397, Metallo_peptidase_C
IPR031489, Peptidase_M99

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17033, Peptidase_M99, 1 hit
PF17129, Peptidase_M99_C, 1 hit
PF17130, Peptidase_M99_m, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O25708-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKIWLLVWG LCSWVFLHAI EMIEKAPTNV EDRDKAPHLL LLAGIQGDEP
60 70 80 90 100
GGFNATNLFL MHYSVLKGLV EVVPVLNKPS MLRNHRGLYG DMNRKFAALD
110 120 130 140 150
KNDPEYPTIQ EIKSLIAKPS IDAVLHLHDG GGYYRPVYVD AMLNPKRWGN
160 170 180 190 200
CFIIDQDEVK GAKFPNLLAF ANNTIESINA HLLHPIEEYH LKNTRTAQGD
210 220 230 240 250
TEMQKALTFY AINQKKSAFA NEASKELPLA SRVFYHLQAI EGLLNQLNIP
260 270 280 290 300
FKRDFDLNPN SVHALINDKN LWAKISSLPK MPLFNLRPKL NHFPLPHNTK
310 320 330 340 350
IPQIPIESNA YIVGLVKNKQ EVFLKYGNKL MTRLSPFYIE FDPSLEEVKM
360 370 380 390 400
QIDNKDQMVK IGSVVEVKES FYIHAMDNIR ANVIGFSVSN ENKPNEAGYT
410 420 430
IKFKDFQKRF SLDKQERIYR IEFYKNNAFS GMILVKFV
Length:438
Mass (Da):50,233
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F15B63DF80D1A54
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08118.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C64654

NCBI Reference Sequences

More...
RefSeqi
NP_207866.1, NC_000915.1
WP_000725381.1, NC_000915.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD08118; AAD08118; HP_1075

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpy:HP1075

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|85962.8.peg.1124

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08118.1
PIRiC64654
RefSeqiNP_207866.1, NC_000915.1
WP_000725381.1, NC_000915.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q6MX-ray1.60A22-438[»]
4Q6NX-ray1.55A22-438[»]
4Q6OX-ray1.41A22-438[»]
4Q6PX-ray2.62A22-438[»]
4Q6QX-ray2.40A22-438[»]
SMRiO25708
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-3761N
IntActiO25708, 1 interactor
MINTiO25708
STRINGi85962.C694_05555

Protein family/group databases

MEROPSiM99.001

Proteomic databases

PaxDbiO25708

Genome annotation databases

EnsemblBacteriaiAAD08118; AAD08118; HP_1075
KEGGihpy:HP1075
PATRICifig|85962.8.peg.1124

Phylogenomic databases

eggNOGiCOG3608, Bacteria
OMAiTFYAINQ

Family and domain databases

InterProiView protein in InterPro
IPR033398, M99_beta-barrel
IPR033397, Metallo_peptidase_C
IPR031489, Peptidase_M99
PfamiView protein in Pfam
PF17033, Peptidase_M99, 1 hit
PF17129, Peptidase_M99_C, 1 hit
PF17130, Peptidase_M99_m, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO25708_HELPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O25708
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 2, 2021
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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