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Protein

Homoserine kinase

Gene

thrB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (lysC)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi83 – 93ATPUniRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1050-MONOMER
UniPathwayiUPA00050; UER00064

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:HP_1050
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001565761 – 293Homoserine kinaseAdd BLAST293

Proteomic databases

PaxDbiO25690

Interactioni

Protein-protein interaction databases

DIPiDIP-3182N
IntActiO25690, 1 interactor
MINTiO25690
STRINGi85962.HP1050

Structurei

3D structure databases

ProteinModelPortaliO25690
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5I Bacteria
COG0083 LUCA
KOiK00872
OMAiPDNVAPC

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
HAMAPiMF_00384 Homoser_kinase, 1 hit
InterProiView protein in InterPro
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR000870 Homoserine_kinase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR20861:SF1 PTHR20861:SF1, 1 hit
PfamiView protein in Pfam
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF000676 Homoser_kin, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR00191 thrB, 1 hit
PROSITEiView protein in PROSITE
PS00627 GHMP_KINASES_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

O25690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSVPATSA NLGPGFDCLG LSLNLRNRFF IEPSSFHAVK LVGEGEGIPK
60 70 80 90 100
FLTNNIFTKV FYEILKKHGN DGSFKFLLHN KVPITRGMGS SSAMIVGAVA
110 120 130 140 150
SAFAFLGFDF DRENIVNTAL IYENHPDNIT PAVFGGYNAA FVEKKKVISL
160 170 180 190 200
KTKIPSFLKA VMVIPNRAIS TKQSRHLLPK RYSVQESVFN LSHASLMTMA
210 220 230 240 250
IVQGKWDLLR CCSKDRMHQY KRMQTYPVLF AIQKIALENN ALMSTLSGSG
260 270 280 290
SSFFNMCYEE DAPKLKQVLS KKFPKFRVAV LDFDNDGVLI EKD
Length:293
Mass (Da):32,663
Last modified:January 1, 1998 - v1
Checksum:iEB73D9C95E4F29AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08095.1
PIRiB64651
RefSeqiNP_207841.1, NC_000915.1
WP_000261726.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08095; AAD08095; HP_1050
GeneIDi899585
KEGGiheo:C694_05430
hpy:HP1050
PATRICifig|85962.47.peg.1129

Similar proteinsi

Entry informationi

Entry nameiKHSE_HELPY
AccessioniPrimary (citable) accession number: O25690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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