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Entry version 89 (17 Jun 2020)
Sequence version 1 (01 Jan 1998)
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Protein
Submitted name:

Cation efflux system protein (CzcA)

Gene

HP_0969

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
HPY:HP0969-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.6.1.14 the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cation efflux system protein (CzcA)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:HP_0969Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei330 – 353HelicalSequence analysisAdd BLAST24
Transmembranei360 – 377HelicalSequence analysisAdd BLAST18
Transmembranei389 – 411HelicalSequence analysisAdd BLAST23
Transmembranei432 – 457HelicalSequence analysisAdd BLAST26
Transmembranei469 – 492HelicalSequence analysisAdd BLAST24
Transmembranei524 – 542HelicalSequence analysisAdd BLAST19
Transmembranei858 – 877HelicalSequence analysisAdd BLAST20
Transmembranei884 – 904HelicalSequence analysisAdd BLAST21
Transmembranei910 – 934HelicalSequence analysisAdd BLAST25
Transmembranei955 – 975HelicalSequence analysisAdd BLAST21
Transmembranei987 – 1014HelicalSequence analysisAdd BLAST28

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O25622

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-3083N

Protein interaction database and analysis system

More...
IntActi
O25622, 5 interactors

Molecular INTeraction database

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MINTi
O25622

STRING: functional protein association networks

More...
STRINGi
85962.C694_04990

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4108IJF Bacteria
COG3696 LUCA

KEGG Orthology (KO)

More...
KOi
K15726

Identification of Orthologs from Complete Genome Data

More...
OMAi
IFMFTID

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004763 CzcA/CusA/SilA/NccA/HelA/CnrA

The PANTHER Classification System

More...
PANTHERi
PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714 SSF82714, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00914 2A0601, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O25622-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLASIIEFS LRQRVIVIVG AILILFFGTY SFINTPVDAF PDISPTQVKI
60 70 80 90 100
ILKLPGSSPE EMENNIVRPL ELELLGLKGQ KSLRSVSKYS ISDITIDFDD
110 120 130 140 150
SVDIYLARNI VNERLSSVMK DLPVGVEGGM APIVTPLSDI FMFTIDGNIT
160 170 180 190 200
EIEKRQLLDF VIRPQLRMIS GVADVNSIGG FSRAFVIVPD FNDMARLGVS
210 220 230 240 250
ISDLESAVRV NLRNSGAGRV DRDGETFLVK IQTASLSLED IGKITVSTNL
260 270 280 290 300
GHLHIKDFAK VISQSRTRLG FVTKDGVGET TEGLVLSLKD ANTKEIITQV
310 320 330 340 350
YQKLEELKPF LPNGVSINVF YDRSEFTQKA IATVSKTLIE AVVLIIITLF
360 370 380 390 400
LFLGNLRASV AVGVILPLSL SVAFIFIKFS DLTLNLMSLG GLVIAIGMLI
410 420 430 440 450
DSAVVVVENA FEKLSANTKT TKLHAIYRSC KEIAVSVVSG VVIIIVFFVP
460 470 480 490 500
ILTLQGLEGK MFRPLAQSIV YALLGTLVLS ITIIPVVSSL VLKATPHSET
510 520 530 540 550
FLTRFLNRIY APLLEFFVHN PKKVILGAFV FLIASLSLFP FVGKNFMPVL
560 570 580 590 600
DEGDVVLSVE TTPSISLDQS RDLMLNIESA IKKHVKEVKS IVARTGSDEL
610 620 630 640 650
GLDLGGLNQT DTFISFIPKK EWSVKTKDEL LEKIMDSLKD FKGINFSFTQ
660 670 680 690 700
PIEMRISEML TGVRGDLAVK IFGDGISELN ELSFQIAQAL KGIKGSSEVL
710 720 730 740 750
TTLNEGVNYL YVTPNKESMA DVGITSDEFS KFLKSALEGL VVDVIPTGIS
760 770 780 790 800
RTPVMIRQES DFASSITKIK SLALTSKYGV LVPITSIAKI EEVDGPVSVV
810 820 830 840 850
RENSMRMSVV RSNVVGRDLK SFVEEAKKVI AQNIKLPPSY YITYGGQFEN
860 870 880 890 900
QQRANKRLST VIPLSILAIF FILFFTFKSI PLALLILLNI PFAVTGGLIA
910 920 930 940 950
LFAVGEYISV PASVGFIALF GIAVLNGVVM IGYFKELLLQ GKSVEECVLL
960 970 980 990 1000
GAKRRLRPVL MTACIAGLGL LPLLFSHSVG SEVQKPLAIV VLGGLVTSSA
1010 1020
LTLLLLPPMF MLIAKKIKIV
Length:1,020
Mass (Da):111,323
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C0D3B12ADCF4731
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08012.1

Protein sequence database of the Protein Information Resource

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PIRi
A64641

NCBI Reference Sequences

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RefSeqi
NP_207760.1, NC_000915.1
WP_000978968.1, NC_018939.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD08012; AAD08012; HP_0969

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
899501

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpy:HP0969

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|85962.8.peg.1007

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08012.1
PIRiA64641
RefSeqiNP_207760.1, NC_000915.1
WP_000978968.1, NC_018939.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-3083N
IntActiO25622, 5 interactors
MINTiO25622
STRINGi85962.C694_04990

Protein family/group databases

TCDBi2.A.6.1.14 the resistance-nodulation-cell division (rnd) superfamily

Proteomic databases

PaxDbiO25622

Genome annotation databases

EnsemblBacteriaiAAD08012; AAD08012; HP_0969
GeneIDi899501
KEGGihpy:HP0969
PATRICifig|85962.8.peg.1007

Phylogenomic databases

eggNOGiENOG4108IJF Bacteria
COG3696 LUCA
KOiK15726
OMAiIFMFTID

Enzyme and pathway databases

BioCyciHPY:HP0969-MONOMER

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004763 CzcA/CusA/SilA/NccA/HelA/CnrA
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits
TIGRFAMsiTIGR00914 2A0601, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO25622_HELPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O25622
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 17, 2020
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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