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UniProtKB - O25584 (SURE_HELPY)
Protein
5'-nucleotidase SurE
Gene
surE
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
UniRule annotationCatalytic activityi
- EC:3.1.3.5UniRule annotation
Cofactori
a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 9 | Divalent metal cationUniRule annotation | 1 | |
Metal bindingi | 10 | Divalent metal cationUniRule annotation | 1 | |
Metal bindingi | 40 | Divalent metal cationUniRule annotation | 1 | |
Metal bindingi | 97 | Divalent metal cationUniRule annotation | 1 |
GO - Molecular functioni
- 3'-nucleotidase activity Source: GO_Central
- 5'-nucleotidase activity Source: GO_Central
- exopolyphosphatase activity Source: GO_Central
- metal ion binding Source: UniProtKB-UniRule
- nucleotide binding Source: UniProtKB-KW
GO - Biological processi
- UMP catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 5'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation)Alternative name(s): Nucleoside 5'-monophosphate phosphohydrolaseUniRule annotation |
Gene namesi | Name:surEUniRule annotation Ordered Locus Names:HP_0930 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000111817 | 1 – 267 | 5'-nucleotidase SurEAdd BLAST | 267 |
Proteomic databases
PaxDbi | O25584 |
Family & Domainsi
Sequence similaritiesi
Belongs to the SurE nucleotidase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0496, Bacteria |
OMAi | DCVHIAL |
PhylomeDBi | O25584 |
Family and domain databases
Gene3Di | 3.40.1210.10, 1 hit |
HAMAPi | MF_00060, SurE, 1 hit |
InterProi | View protein in InterPro IPR030048, SurE IPR002828, SurE-like_Pase/nucleotidase IPR036523, SurE-like_sf |
PANTHERi | PTHR30457, PTHR30457, 1 hit |
Pfami | View protein in Pfam PF01975, SurE, 1 hit |
SUPFAMi | SSF64167, SSF64167, 1 hit |
TIGRFAMsi | TIGR00087, surE, 1 hit |
i Sequence
Sequence statusi: Complete.
O25584-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKILLTNDD GYHAKGIKAL EQALEEMAEI YVVAPKHEKS ACSQCITITA
60 70 80 90 100
PLRAEKIKGK EGRHYRIDDG TPSDCVYLAI NELFKHVCFD LVISGINLGS
110 120 130 140 150
NMGEDTIYSG TVAGAIEGTI QGVPSIAISQ ILSNKNKNTP LSFDLAQKII
160 170 180 190 200
QDLVQNIFTK GYPLKGRKLL NVNVPNCSLQ EYQGERITPK GYRLYKKEVH
210 220 230 240 250
KRTDPKNESY FWLGLHPLEW QKRENEDRLS DFDAIASNHA SITPLNLDLT
260
SYDDLKSLES WHEGMLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07975.1 |
PIRi | B64636 |
RefSeqi | NP_207722.1, NC_000915.1 WP_000722451.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD07975; AAD07975; HP_0930 |
KEGGi | hpy:HP_0930 |
PATRICi | fig|85962.47.peg.995 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07975.1 |
PIRi | B64636 |
RefSeqi | NP_207722.1, NC_000915.1 WP_000722451.1, NC_018939.1 |
3D structure databases
SMRi | O25584 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 85962.C694_04785 |
Proteomic databases
PaxDbi | O25584 |
Genome annotation databases
EnsemblBacteriai | AAD07975; AAD07975; HP_0930 |
KEGGi | hpy:HP_0930 |
PATRICi | fig|85962.47.peg.995 |
Phylogenomic databases
eggNOGi | COG0496, Bacteria |
OMAi | DCVHIAL |
PhylomeDBi | O25584 |
Family and domain databases
Gene3Di | 3.40.1210.10, 1 hit |
HAMAPi | MF_00060, SurE, 1 hit |
InterProi | View protein in InterPro IPR030048, SurE IPR002828, SurE-like_Pase/nucleotidase IPR036523, SurE-like_sf |
PANTHERi | PTHR30457, PTHR30457, 1 hit |
Pfami | View protein in Pfam PF01975, SurE, 1 hit |
SUPFAMi | SSF64167, SSF64167, 1 hit |
TIGRFAMsi | TIGR00087, surE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SURE_HELPY | |
Accessioni | O25584Primary (citable) accession number: O25584 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families