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UniProtKB - O25549 (RUVA_HELPY)
Protein
Holliday junction ATP-dependent DNA helicase RuvA
Gene
ruvA
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
UniRule annotationCatalytic activityi
- EC:3.6.4.12UniRule annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: RHEA
- DNA binding Source: UniProtKB-KW
- four-way junction helicase activity Source: UniProtKB-UniRule
GO - Biological processi
- DNA recombination Source: UniProtKB-UniRule
- DNA repair Source: UniProtKB-UniRule
- SOS response Source: UniProtKB-UniRule
Keywordsi
Molecular function | DNA-binding, Helicase, Hydrolase |
Biological process | DNA damage, DNA recombination, DNA repair, SOS response |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation) |
Gene namesi | Name:ruvAUniRule annotation Ordered Locus Names:HP_0883 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094639 | 1 – 183 | Holliday junction ATP-dependent DNA helicase RuvAAdd BLAST | 183 |
Proteomic databases
PaxDbi | O25549 |
Interactioni
Subunit structurei
Forms a complex with RuvB.
UniRule annotationProtein-protein interaction databases
IntActi | O25549, 1 interactor |
STRINGi | 85962.C694_04525 |
Family & Domainsi
Sequence similaritiesi
Belongs to the RuvA family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0632, Bacteria |
OMAi | VGMAVQC |
PhylomeDBi | O25549 |
Family and domain databases
CDDi | cd14332, UBA_RuvA_C, 1 hit |
HAMAPi | MF_00031, DNA_helic_RuvA, 1 hit |
InterProi | View protein in InterPro IPR013849, DNA_helicase_Holl-junc_RuvA_I IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif IPR012340, NA-bd_OB-fold IPR000085, RuvA IPR010994, RuvA_2-like IPR011114, RuvA_C IPR036267, RuvA_C_sf |
Pfami | View protein in Pfam PF07499, RuvA_C, 1 hit PF01330, RuvA_N, 1 hit |
SMARTi | View protein in SMART SM00278, HhH1, 2 hits |
SUPFAMi | SSF46929, SSF46929, 1 hit SSF47781, SSF47781, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00084, ruvA, 1 hit |
i Sequence
Sequence statusi: Complete.
O25549-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIVGLIGVVE KISALEVHIE VQGVVYGVQV SMRTAALLEA GQKARLKILQ
60 70 80 90 100
VIKEDAHLLY GFLEEGEKIL FERLLKINGV GGRIALAILS SFSPNEFESI
110 120 130 140 150
IATKEVKRLQ QVPGIGKKLA DKIMVDLIGF FIQDENRPAR NEVFLALESL
160 170 180
GFKSAEINQV LKTLKPNLSI EAAIKEALQQ LRS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07932.1 |
PIRi | C64630 |
RefSeqi | NP_207676.1, NC_000915.1 WP_000635172.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD07932; AAD07932; HP_0883 |
KEGGi | hpy:HP_0883 |
PATRICi | fig|85962.47.peg.939 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07932.1 |
PIRi | C64630 |
RefSeqi | NP_207676.1, NC_000915.1 WP_000635172.1, NC_018939.1 |
3D structure databases
SMRi | O25549 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | O25549, 1 interactor |
STRINGi | 85962.C694_04525 |
Proteomic databases
PaxDbi | O25549 |
Genome annotation databases
EnsemblBacteriai | AAD07932; AAD07932; HP_0883 |
KEGGi | hpy:HP_0883 |
PATRICi | fig|85962.47.peg.939 |
Phylogenomic databases
eggNOGi | COG0632, Bacteria |
OMAi | VGMAVQC |
PhylomeDBi | O25549 |
Family and domain databases
CDDi | cd14332, UBA_RuvA_C, 1 hit |
HAMAPi | MF_00031, DNA_helic_RuvA, 1 hit |
InterProi | View protein in InterPro IPR013849, DNA_helicase_Holl-junc_RuvA_I IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif IPR012340, NA-bd_OB-fold IPR000085, RuvA IPR010994, RuvA_2-like IPR011114, RuvA_C IPR036267, RuvA_C_sf |
Pfami | View protein in Pfam PF07499, RuvA_C, 1 hit PF01330, RuvA_N, 1 hit |
SMARTi | View protein in SMART SM00278, HhH1, 2 hits |
SUPFAMi | SSF46929, SSF46929, 1 hit SSF47781, SSF47781, 1 hit SSF50249, SSF50249, 1 hit |
TIGRFAMsi | TIGR00084, ruvA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RUVA_HELPY | |
Accessioni | O25549Primary (citable) accession number: O25549 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families