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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75SubstrateUniRule annotation1
Binding sitei89Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0865-MONOMER
UniPathwayi
UPA00610;UER00666

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotation
Ordered Locus Names:HP_0865
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001828691 – 145Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST145

Proteomic databases

PaxDbiO25536

Interactioni

Protein-protein interaction databases

IntActiO25536, 1 interactor
STRINGi85962.HP0865

Structurei

3D structure databases

ProteinModelPortaliO25536
SMRiO25536
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 64Substrate bindingUniRule annotation3
Regioni79 – 81Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z1K Bacteria
COG0756 LUCA
KOiK01520
OMAiGVILINH

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00116 dUTPase_bact, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR008181 dUTPase_1
IPR033704 dUTPase_trimeric
PANTHERiPTHR11241 PTHR11241, 1 hit
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR00576 dut, 1 hit

Sequencei

Sequence statusi: Complete.

O25536-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIKIQKIHP NALIPKYQTD GSSGFDLHAV EEVMIKPHSV GLVKIGICLS
60 70 80 90 100
LEVGYELQVR TRSGLALNHQ VMVLNSPGTV DNDYRGEIKV ILANLSDKDF
110 120 130 140
KVQVGDRIAQ GVVQKTYKAE FIECEQLDET SRGSGGFGST GVSKA
Length:145
Mass (Da):15,801
Last modified:January 1, 1998 - v1
Checksum:i98504D2FC8605013
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07907.1
PIRiA64628
RefSeqiNP_207659.1, NC_000915.1
WP_000694145.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD07907; AAD07907; HP_0865
GeneIDi899394
KEGGiheo:C694_04430
hpy:HP0865
PATRICifig|85962.47.peg.919

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07907.1
PIRiA64628
RefSeqiNP_207659.1, NC_000915.1
WP_000694145.1, NC_018939.1

3D structure databases

ProteinModelPortaliO25536
SMRiO25536
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO25536, 1 interactor
STRINGi85962.HP0865

Proteomic databases

PaxDbiO25536

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07907; AAD07907; HP_0865
GeneIDi899394
KEGGiheo:C694_04430
hpy:HP0865
PATRICifig|85962.47.peg.919

Phylogenomic databases

eggNOGiENOG4108Z1K Bacteria
COG0756 LUCA
KOiK01520
OMAiGVILINH

Enzyme and pathway databases

UniPathwayi
UPA00610;UER00666

BioCyciHPY:HP0865-MONOMER

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00116 dUTPase_bact, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR008181 dUTPase_1
IPR033704 dUTPase_trimeric
PANTHERiPTHR11241 PTHR11241, 1 hit
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR00576 dut, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUT_HELPY
AccessioniPrimary (citable) accession number: O25536
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 10, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
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Main funding by: National Institutes of Health

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