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Entry version 133 (29 Sep 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP + H(2)O + cellular protein(Side 1) = ADP + phosphate + cellular protein(Side 2).UniRule annotation EC:7.4.2.8

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei93ATPUniRule annotation1
Binding sitei501ATPUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi841ZincUniRule annotation1
Metal bindingi843ZincUniRule annotation1
Metal bindingi852ZincUniRule annotation1
Metal bindingi853ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi111 – 115ATPUniRule annotation5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processProtein transport, Translocation, Transport
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
HPY:HP0786-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation (EC:7.4.2.8UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:HP_0786
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001095871 – 865Protein translocase subunit SecAAdd BLAST865

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O25475

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

UniRule annotation

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-3356N

Protein interaction database and analysis system

More...
IntActi
O25475, 1 interactor

Molecular INTeraction database

More...
MINTi
O25475

STRING: functional protein association networks

More...
STRINGi
85962.C694_04030

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O25475

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0653, Bacteria

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVHYDVQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O25475

Family and domain databases

Conserved Domains Database

More...
CDDi
cd18803, SF2_C_secA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 3 hits

HAMAP database of protein families

More...
HAMAPi
MF_01382, SecA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR004027, SEC_C_motif
IPR000185, SecA
IPR020937, SecA_CS
IPR011115, SecA_DEAD
IPR014018, SecA_motor_DEAD
IPR011130, SecA_preprotein_X-link_dom
IPR044722, SecA_SF2_C
IPR011116, SecA_Wing/Scaffold
IPR036266, SecA_Wing/Scaffold_sf
IPR036670, SecA_X-link_sf

The PANTHER Classification System

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PANTHERi
PTHR30612, PTHR30612, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02810, SEC-C, 1 hit
PF07517, SecA_DEAD, 1 hit
PF01043, SecA_PP_bind, 1 hit
PF07516, SecA_SW, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00906, SECA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00957, SecA_DEAD, 1 hit
SM00958, SecA_PP_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF81767, SSF81767, 1 hit
SSF81886, SSF81886, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00963, secA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01312, SECA, 1 hit
PS51196, SECA_MOTOR_DEAD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O25475-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKAIIGKII GTRNDRWIKQ YKKQVLTINA LEPTYEKMSD DELQNAFEEL
60 70 80 90 100
KKRVRSTEKD LQEKTLLEVL PESFAITREA SKRILKMCHF DVQLIGGMVL
110 120 130 140 150
NDGKIAEMKT GEGKTLVATL AVALNALKGE SVYVVTVNDY LAHRDSKEME
160 170 180 190 200
PLYHFLGYSV GTITASVRDD DERLEIYSKD IVYGTNNEFG FDYLRDNMKY
210 220 230 240 250
SLEHKVQKSH AFAIVDEVDS ILIDEARTPL IISGPVDRRM ENYNKADEVA
260 270 280 290 300
KSMQVEIDFT IDEKNRAILI TEEGIKKAEN LFGVDNLYKI ENAALSHHLD
310 320 330 340 350
QALKANYLFF IDKDYIVANN EVVIVDEFTG RLSEGRRFSE GLHQALEAKE
360 370 380 390 400
GVSIKEESQT LADITFQNYF RMFSKLAGMT GTAQTEATEF LEIYNLEVVS
410 420 430 440 450
IPTNLAIKRK DLNDLIYKSE KEKFDAVILK IKELHDKGQP VLVGTASIEK
460 470 480 490 500
SETLHALLKK ERIPHTVLNA KQHTKEAEII KDAGLKGAVT IATNMAGRGV
510 520 530 540 550
DIKLTDEIKE LGGLYIIGTE RHESRRIDNQ LRGRSGRQGD PGTSQFYLSL
560 570 580 590 600
EDNLLRIFGS DRIKGVMEKL GLKDGEHIES KLVTRAVENA QKKVENLHFE
610 620 630 640 650
SRKHLLEYDD VANEQRKSVY KFRDELLDVN YDISAKIAEN REYALNQIFS
660 670 680 690 700
KLKAFDHQNL SEEELLGLKN ILKEDFNAHV SLEDLKKASP IENFVAEKLK
710 720 730 740 750
SDYENKMKVL DSEQRSRIER IVYLQILDNA WREHLYTMDN LKTGINLRGY
760 770 780 790 800
NQKDPLVEYK KESYNLFLEF IEDIKTEAIK TFSKIQFENE QDSSDAERYL
810 820 830 840 850
DNFSEEREHE SVTYRHEEAL DEDLNVAMKA FAKTPKRNEP CPCQSGKKYK
860
DCCAKSGPKK GLFAK
Length:865
Mass (Da):99,084
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i472D8F86D791A8BD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07830.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B64618

NCBI Reference Sequences

More...
RefSeqi
NP_207579.1, NC_000915.1
WP_000588147.1, NC_018939.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD07830; AAD07830; HP_0786

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpy:HP0786

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|85962.47.peg.838

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07830.1
PIRiB64618
RefSeqiNP_207579.1, NC_000915.1
WP_000588147.1, NC_018939.1

3D structure databases

SMRiO25475
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-3356N
IntActiO25475, 1 interactor
MINTiO25475
STRINGi85962.C694_04030

Proteomic databases

PaxDbiO25475

Genome annotation databases

EnsemblBacteriaiAAD07830; AAD07830; HP_0786
KEGGihpy:HP0786
PATRICifig|85962.47.peg.838

Phylogenomic databases

eggNOGiCOG0653, Bacteria
OMAiMVHYDVQ
PhylomeDBiO25475

Enzyme and pathway databases

BioCyciHPY:HP0786-MONOMER

Family and domain databases

CDDicd18803, SF2_C_secA, 1 hit
Gene3Di3.40.50.300, 3 hits
HAMAPiMF_01382, SecA, 1 hit
InterProiView protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR004027, SEC_C_motif
IPR000185, SecA
IPR020937, SecA_CS
IPR011115, SecA_DEAD
IPR014018, SecA_motor_DEAD
IPR011130, SecA_preprotein_X-link_dom
IPR044722, SecA_SF2_C
IPR011116, SecA_Wing/Scaffold
IPR036266, SecA_Wing/Scaffold_sf
IPR036670, SecA_X-link_sf
PANTHERiPTHR30612, PTHR30612, 1 hit
PfamiView protein in Pfam
PF02810, SEC-C, 1 hit
PF07517, SecA_DEAD, 1 hit
PF01043, SecA_PP_bind, 1 hit
PF07516, SecA_SW, 1 hit
PRINTSiPR00906, SECA
SMARTiView protein in SMART
SM00957, SecA_DEAD, 1 hit
SM00958, SecA_PP_bind, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF81767, SSF81767, 1 hit
SSF81886, SSF81886, 1 hit
TIGRFAMsiTIGR00963, secA, 1 hit
PROSITEiView protein in PROSITE
PS01312, SECA, 1 hit
PS51196, SECA_MOTOR_DEAD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSECA_HELPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O25475
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 29, 2021
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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