UniProtKB - O25441 (Y745_HELPY)
Protein
Uncharacterized RNA pseudouridine synthase HP_0745
Gene
HP_0745
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 136 | By similarity | 1 |
GO - Molecular functioni
- pseudouridine synthase activity Source: GO_Central
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- enzyme-directed rRNA pseudouridine synthesis Source: GO_Central
Keywordsi
Molecular function | Isomerase, RNA-binding |
Enzyme and pathway databases
BioCyci | HPY:HP0745-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized RNA pseudouridine synthase HP_0745 (EC:5.4.99.-)Alternative name(s): RNA pseudouridylate synthase RNA-uridine isomerase |
Gene namesi | Ordered Locus Names:HP_0745 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000162735 | 1 – 327 | Uncharacterized RNA pseudouridine synthase HP_0745Add BLAST | 327 |
Proteomic databases
PaxDbi | O25441 |
Interactioni
Protein-protein interaction databases
DIPi | DIP-3289N |
IntActi | O25441, 2 interactors |
MINTi | O25441 |
STRINGi | 85962.C694_03835 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 79 | S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST | 68 |
Sequence similaritiesi
Belongs to the pseudouridine synthase RluA family.Curated
Phylogenomic databases
eggNOGi | COG0564, Bacteria |
OMAi | AHPSPGW |
Family and domain databases
CDDi | cd02869, PseudoU_synth_RluCD_like, 1 hit cd00165, S4, 1 hit |
Gene3Di | 3.10.290.10, 1 hit |
InterProi | View protein in InterPro IPR020103, PsdUridine_synth_cat_dom_sf IPR006225, PsdUridine_synth_RluC/D IPR006224, PsdUridine_synth_RluC/D_CS IPR006145, PsdUridine_synth_RsuA/RluA IPR002942, S4_RNA-bd IPR036986, S4_RNA-bd_sf |
Pfami | View protein in Pfam PF00849, PseudoU_synth_2, 1 hit PF01479, S4, 1 hit |
SMARTi | View protein in SMART SM00363, S4, 1 hit |
SUPFAMi | SSF55120, SSF55120, 1 hit |
TIGRFAMsi | TIGR00005, rluA_subfam, 1 hit |
PROSITEi | View protein in PROSITE PS01129, PSI_RLU, 1 hit PS50889, S4, 1 hit |
i Sequence
Sequence statusi: Complete.
O25441-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQKVFIALTD HKRLDEFLAK ELQISKNQVL NLIKEGLVFC QKKEVKKGGL
60 70 80 90 100
ALKEGDEITL LTPKITPKPL KKELDLEIEV IFEDEDLLVL NKPPNLVVHK
110 120 130 140 150
ALSVKEPTLV DWLEFKNYEL SNLGLKERYG IVHRLDKDTS GGIVIAKNNF
160 170 180 190 200
THVHLSEQLK TKMMGRYYIA LLSTPLKEEK MSVECYLTRN PNNRLKMIAL
210 220 230 240 250
KAVKKEKSRY SKSEFISLLT SQNNLNLIGA KLFTGRTHQI RAHLEYLNRH
260 270 280 290 300
IIGDNLYGLN GALPKEEIRI MLHAYLIEFK HPRSEQKLRF KVPLLKDMLE
310 320
YLKKVFDKEN LDEVLDEEKI LHAFIAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07795.1 |
PIRi | A64613 |
RefSeqi | NP_207538.1, NC_000915.1 WP_001174316.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD07795; AAD07795; HP_0745 |
KEGGi | heo:C694_03835 hpy:HP0745 |
PATRICi | fig|85962.47.peg.795 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07795.1 |
PIRi | A64613 |
RefSeqi | NP_207538.1, NC_000915.1 WP_001174316.1, NC_018939.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
DIPi | DIP-3289N |
IntActi | O25441, 2 interactors |
MINTi | O25441 |
STRINGi | 85962.C694_03835 |
Proteomic databases
PaxDbi | O25441 |
Genome annotation databases
EnsemblBacteriai | AAD07795; AAD07795; HP_0745 |
KEGGi | heo:C694_03835 hpy:HP0745 |
PATRICi | fig|85962.47.peg.795 |
Phylogenomic databases
eggNOGi | COG0564, Bacteria |
OMAi | AHPSPGW |
Enzyme and pathway databases
BioCyci | HPY:HP0745-MONOMER |
Family and domain databases
CDDi | cd02869, PseudoU_synth_RluCD_like, 1 hit cd00165, S4, 1 hit |
Gene3Di | 3.10.290.10, 1 hit |
InterProi | View protein in InterPro IPR020103, PsdUridine_synth_cat_dom_sf IPR006225, PsdUridine_synth_RluC/D IPR006224, PsdUridine_synth_RluC/D_CS IPR006145, PsdUridine_synth_RsuA/RluA IPR002942, S4_RNA-bd IPR036986, S4_RNA-bd_sf |
Pfami | View protein in Pfam PF00849, PseudoU_synth_2, 1 hit PF01479, S4, 1 hit |
SMARTi | View protein in SMART SM00363, S4, 1 hit |
SUPFAMi | SSF55120, SSF55120, 1 hit |
TIGRFAMsi | TIGR00005, rluA_subfam, 1 hit |
PROSITEi | View protein in PROSITE PS01129, PSI_RLU, 1 hit PS50889, S4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Y745_HELPY | |
Accessioni | O25441Primary (citable) accession number: O25441 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families