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UniProtKB - O25396 (FEOB_HELPY)
Protein
Fe(2+) transporter FeoB
Gene
feoB
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Probable transporter of an ATP-driven Fe2+ uptake system.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 17 | GTP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 35 – 39 | GTP 2PROSITE-ProRule annotation | 5 | |
Nucleotide bindingi | 56 – 59 | GTP 3PROSITE-ProRule annotation | 4 | |
Nucleotide bindingi | 116 – 119 | GTPPROSITE-ProRule annotation | 4 | |
Nucleotide bindingi | 145 – 147 | GTPPROSITE-ProRule annotation | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ferrous iron transmembrane transporter activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- iron ion homeostasis Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | ATP-binding, GTP-binding, Iron, Nucleotide-binding |
Protein family/group databases
TCDBi | 9.A.8.1.2, the ferrous iron uptake (feob) family |
Names & Taxonomyi
Protein namesi | Recommended name: Fe(2+) transporter FeoBCuratedAlternative name(s): Ferrous iron transport protein B |
Gene namesi | Name:feoB Ordered Locus Names:HP_0687 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 226 – 246 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 279 – 299 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 361 – 381 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 388 – 408 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 447 – 467 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 541 – 561 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 586 – 606 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 615 – 635 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Cells are unable to colonize the gastric mucosa of mice.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210830 | 1 – 642 | Fe(2+) transporter FeoBAdd BLAST | 642 |
Proteomic databases
PaxDbi | O25396 |
Interactioni
Protein-protein interaction databases
DIPi | DIP-3079N |
IntActi | O25396, 19 interactors |
MINTi | O25396 |
STRINGi | 85962.C694_03545 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 168 | FeoB-type GPROSITE-ProRule annotationAdd BLAST | 166 |
Sequence similaritiesi
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. [View classification]PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0370, Bacteria |
OMAi | PLGYDWK |
PhylomeDBi | O25396 |
Family and domain databases
CDDi | cd01879, FeoB, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003373, Fe2_transport_prot-B IPR011640, Fe2_transport_prot_B_C IPR030389, G_FEOB_dom IPR011642, Gate_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF07664, FeoB_C, 1 hit PF02421, FeoB_N, 1 hit PF07670, Gate, 2 hits |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00437, feoB, 1 hit |
PROSITEi | View protein in PROSITE PS51711, G_FEOB, 1 hit |
i Sequence
Sequence statusi: Complete.
O25396-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKEITIALVG QPNVGKSSLI NALSNAHLKV GNFAGVTVDK MEVGLIHKEH
60 70 80 90 100
QITIIDLPGT YALNDFTTEE KVTKDFLEKG QYDLILNVVD STNLERNLAL
110 120 130 140 150
SAQLLDTNKK MLLALNMWDE AQKEGIKINT EKLSKELGVV CVPTSARSKE
160 170 180 190 200
DRLNTELLLD EIVRLYSQNT TNNENIKVPS QSFKESLKYS QSAQRIAQLV
210 220 230 240 250
ISENQQNASF EHTYKIDKIL MHKRYGIFIF LGFMFIIFSL SFLIGGGVQK
260 270 280 290 300
ALETGFKFLS DGIKENVANE DLASLVGDGI IGGVGATVSF LPLIVVLYFG
310 320 330 340 350
ISLLETTGYM SRVAFLLDGI LHKFGLHGKS FIPLITGFGC SVPAYMATRT
360 370 380 390 400
LQNYNERLIT LFVIGFMSCS ARLPIYVLFV GSFFPSSSAG FVLFCIYILG
410 420 430 440 450
AVVALVMAKL LKLSVFKGQT ESFIMEMPKY RFPSWRMVYF SIYTKSLSYL
460 470 480 490 500
KKAGTYILVG AILIWFMSQY PKSDAAMKAY KQESLLVNKD TTLSSEAKEE
510 520 530 540 550
KLKELKTELD KKNLKNSIVG RGGAYLEKVF SPMDFDWRLS VSLVTGFMAK
560 570 580 590 600
EVVVSTLGVL FSLGDQNEKS DAFRGILRKE VSVPSGIAFI VFVMFYIPCF
610 620 630 640
AATITFGREA GGIKFVAYLF IFTTVVAYAF SLIAFYATQI LV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07741.1 |
PIRi | G64605 |
RefSeqi | NP_207481.1, NC_000915.1 WP_000659176.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD07741; AAD07741; HP_0687 |
KEGGi | hpy:HP_0687 |
PATRICi | fig|85962.47.peg.736 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07741.1 |
PIRi | G64605 |
RefSeqi | NP_207481.1, NC_000915.1 WP_000659176.1, NC_018939.1 |
3D structure databases
SMRi | O25396 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-3079N |
IntActi | O25396, 19 interactors |
MINTi | O25396 |
STRINGi | 85962.C694_03545 |
Protein family/group databases
TCDBi | 9.A.8.1.2, the ferrous iron uptake (feob) family |
Proteomic databases
PaxDbi | O25396 |
Genome annotation databases
EnsemblBacteriai | AAD07741; AAD07741; HP_0687 |
KEGGi | hpy:HP_0687 |
PATRICi | fig|85962.47.peg.736 |
Phylogenomic databases
eggNOGi | COG0370, Bacteria |
OMAi | PLGYDWK |
PhylomeDBi | O25396 |
Family and domain databases
CDDi | cd01879, FeoB, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003373, Fe2_transport_prot-B IPR011640, Fe2_transport_prot_B_C IPR030389, G_FEOB_dom IPR011642, Gate_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF07664, FeoB_C, 1 hit PF02421, FeoB_N, 1 hit PF07670, Gate, 2 hits |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00437, feoB, 1 hit |
PROSITEi | View protein in PROSITE PS51711, G_FEOB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FEOB_HELPY | |
Accessioni | O25396Primary (citable) accession number: O25396 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families