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UniProtKB - O25249 (PGBA_HELPY)
Protein
Plasminogen-binding protein PgbA
Gene
pgbA
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Binds plasminogen, specifically, and in a concentration and lysine-dependent manner. Plasminogen is the precursor of plasmin, a serine protease that cleaves fibrin, fibronectin, laminin and vitronectin. Acquisition of plasminogen/plasmin could enable H.pylori to degrade host components.
Miscellaneous
Plasminogen bound to PgbA is capable of being converted to functionally active plasmin.
Names & Taxonomyi
Protein namesi | Recommended name: Plasminogen-binding protein PgbA |
Gene namesi | Name:pgbA Ordered Locus Names:HP_0508 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Subcellular locationi
Other locations
- Cell surface Curated
Note: The plasminogen-binding region is localized on the surface the bacterium.Curated
Other locations
- cell surface Source: UniProtKB-SubCell
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058351 | 1 – 452 | Plasminogen-binding protein PgbAAdd BLAST | 452 |
Proteomic databases
PaxDbi | O25249 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 265 – 452 | DisorderedSequence analysisAdd BLAST | 188 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 272 – 286 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 287 – 370 | Basic and acidic residuesSequence analysisAdd BLAST | 84 | |
Compositional biasi | 372 – 388 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 389 – 452 | Basic and acidic residuesSequence analysisAdd BLAST | 64 |
Phylogenomic databases
OMAi | HLPTPRM |
Family and domain databases
InterProi | View protein in InterPro IPR032737, PGBA_C IPR029276, PgbA_N |
Pfami | View protein in Pfam PF15437, PGBA_C, 2 hits PF15436, PGBA_N, 1 hit |
i Sequence
Sequence statusi: Complete.
O25249-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRLLIGLLL MSFISLQSAS WQEPLRVSIE FVDLPKKIIR FPAHDLQVGE
60 70 80 90 100
FGFVVTKLSD YEIVNSEVVI IAVENGVATA KFRAFESMKQ RHLPTPRMVA
110 120 130 140 150
RKGDLVYFRQ FNNQAFLIAP NDELYEQIRA TNTDINFISS DLLVTFLNGF
160 170 180 190 200
DPKIANLRKA CNVYSVGVIY IVTTNTLNIL SCESFEILEK RELDTSGVTK
210 220 230 240 250
TSTPFFSRVE GIDAGTLGKL FSGSQSKNYF AYYDALVKKE KRKEVRIKKR
260 270 280 290 300
EEKIDSREIK REIKQEAIKE PKKANQGTQN APTLEEKNYQ KAERKLDAKE
310 320 330 340 350
ERRYLRDERK KAKATKKAME FEEREKEHDE RDEQETEGRR KALEMDKGDK
360 370 380 390 400
KEERVKPKEN EREIKQEAIK EPSDGNNATQ QGEKQNAPKE NNAQKEENKP
410 420 430 440 450
NSKEEKRRLK EEKKKAKAEQ RAREFEQRAR EHQERDEKEL EERRKALEAG
KK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 91 | R → S in strain: CCUG 17874. | 1 | |
Natural varianti | 138 | Missing in strain: CCUG 17874. | 1 | |
Natural varianti | 199 | T → I in strain: CCUG 17874. | 1 | |
Natural varianti | 252 | E → G in strain: CCUG 17874. | 1 | |
Natural varianti | 279 | Q → E in strain: CCUG 17874. | 1 | |
Natural varianti | 349 | D → N in strain: CCUG 17874. | 1 | |
Natural varianti | 350 – 352 | Missing in strain: CCUG 17874. | 3 | |
Natural varianti | 354 | R → K in strain: CCUG 17874. | 1 | |
Natural varianti | 356 – 357 | KP → NA in strain: CCUG 17874. | 2 | |
Natural varianti | 373 – 374 | SD → DN in strain: CCUG 17874. | 2 | |
Natural varianti | 394 | Q → S in strain: CCUG 17874. | 1 | |
Natural varianti | 398 | N → K in strain: CCUG 17874. | 1 | |
Natural varianti | 449 – 450 | AG → MN in strain: CCUG 17874. | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07578.1 AJ550456 Genomic DNA Translation: CAD79440.1 |
PIRi | D64583 |
RefSeqi | NP_207305.1, NC_000915.1 WP_000945103.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD07578; AAD07578; HP_0508 |
KEGGi | hpy:HP_0508 |
PATRICi | fig|85962.47.peg.546 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07578.1 AJ550456 Genomic DNA Translation: CAD79440.1 |
PIRi | D64583 |
RefSeqi | NP_207305.1, NC_000915.1 WP_000945103.1, NC_018939.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 85962.C694_02610 |
Proteomic databases
PaxDbi | O25249 |
Genome annotation databases
EnsemblBacteriai | AAD07578; AAD07578; HP_0508 |
KEGGi | hpy:HP_0508 |
PATRICi | fig|85962.47.peg.546 |
Phylogenomic databases
OMAi | HLPTPRM |
Family and domain databases
InterProi | View protein in InterPro IPR032737, PGBA_C IPR029276, PgbA_N |
Pfami | View protein in Pfam PF15437, PGBA_C, 2 hits PF15436, PGBA_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PGBA_HELPY | |
Accessioni | O25249Primary (citable) accession number: O25249 Secondary accession number(s): Q70SU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |