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UniProtKB - O25150 (CMOA_HELPY)
Protein
Carboxy-S-adenosyl-L-methionine synthase
Gene
cmoA
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
UniRule annotationCatalytic activityi
- prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2OUniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 35 | S-adenosyl-L-methionineUniRule annotation | 1 | |
Binding sitei | 199 | S-adenosyl-L-methionineUniRule annotation | 1 |
GO - Molecular functioni
- carboxyl- or carbamoyltransferase activity Source: UniProtKB-UniRule
- S-adenosyl-L-methionine binding Source: UniProtKB-UniRule
GO - Biological processi
- cellular response to iron ion Source: CollecTF
- tRNA wobble uridine modification Source: InterPro
Keywordsi
Molecular function | Transferase |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Carboxy-S-adenosyl-L-methionine synthaseUniRule annotation (EC:2.1.3.-UniRule annotation)Short name: Cx-SAM synthaseUniRule annotation |
Gene namesi | Name:cmoAUniRule annotation Ordered Locus Names:HP_0388 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000314340 | 1 – 243 | Carboxy-S-adenosyl-L-methionine synthaseAdd BLAST | 243 |
Proteomic databases
PaxDbi | O25150 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 85962.C694_01970 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 68 – 70 | S-adenosyl-L-methionine bindingUniRule annotation | 3 | |
Regioni | 92 – 93 | S-adenosyl-L-methionine bindingUniRule annotation | 2 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG2226, Bacteria |
OMAi | MIELYYL |
PhylomeDBi | O25150 |
Family and domain databases
HAMAPi | MF_01589, Cx_SAM_synthase, 1 hit |
InterProi | View protein in InterPro IPR005271, CmoA IPR041698, Methyltransf_25 IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR43861:SF2, PTHR43861:SF2, 1 hit |
Pfami | View protein in Pfam PF13649, Methyltransf_25, 1 hit |
PIRSFi | PIRSF006325, MeTrfase_bac, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
TIGRFAMsi | TIGR00740, TIGR00740, 1 hit |
i Sequence
Sequence statusi: Complete.
O25150-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDTLFNESL NKRFCFDEKV AHVFDDMLER SIPYYHEMLN LGAYFIAQNL
60 70 80 90 100
KENIYPKSLP KPLIYDLGCS TGNFFIALNR QIQQEIELVG IDNSMPMLKK
110 120 130 140 150
AQEKLKDFNN ARFECMDFLE VEFKEASAFS LLFVLQFVRP MQREVLLKKI
160 170 180 190 200
YNSLALNGVL LVGEKIMSED RILDKQMIEL YYLYKQNQGY SHNEIAFKRE
210 220 230 240
ALENVLVPYS LKENVALLES VGFKHVEALF KWVNFTLLVA RKT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07453.1 |
PIRi | D64568 |
RefSeqi | NP_207186.1, NC_000915.1 WP_000655545.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD07453; AAD07453; HP_0388 |
KEGGi | hpy:HP_0388 |
PATRICi | fig|85962.47.peg.412 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07453.1 |
PIRi | D64568 |
RefSeqi | NP_207186.1, NC_000915.1 WP_000655545.1, NC_018939.1 |
3D structure databases
SMRi | O25150 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 85962.C694_01970 |
Proteomic databases
PaxDbi | O25150 |
Genome annotation databases
EnsemblBacteriai | AAD07453; AAD07453; HP_0388 |
KEGGi | hpy:HP_0388 |
PATRICi | fig|85962.47.peg.412 |
Phylogenomic databases
eggNOGi | COG2226, Bacteria |
OMAi | MIELYYL |
PhylomeDBi | O25150 |
Family and domain databases
HAMAPi | MF_01589, Cx_SAM_synthase, 1 hit |
InterProi | View protein in InterPro IPR005271, CmoA IPR041698, Methyltransf_25 IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR43861:SF2, PTHR43861:SF2, 1 hit |
Pfami | View protein in Pfam PF13649, Methyltransf_25, 1 hit |
PIRSFi | PIRSF006325, MeTrfase_bac, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
TIGRFAMsi | TIGR00740, TIGR00740, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CMOA_HELPY | |
Accessioni | O25150Primary (citable) accession number: O25150 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families