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Entry version 115 (29 Sep 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Succinyl-diaminopimelate desuccinylase

Gene

dapE

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.

UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotation, Co2+UniRule annotationNote: Binds 2 Zn2+ or Co2+ ions per subunit.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 3 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route).UniRule annotation This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi79Zinc 1UniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei81UniRule annotation1
Metal bindingi110Zinc 1UniRule annotation1
Metal bindingi110Zinc 2UniRule annotation1
Active sitei141Proton acceptorUniRule annotation1
Metal bindingi142Zinc 2UniRule annotation1
Metal bindingi170Zinc 1UniRule annotation1
Metal bindingi355Zinc 2UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis
LigandCobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
HPY:HP0212-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.1.18, 2604

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00034;UER00021

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Succinyl-diaminopimelate desuccinylaseUniRule annotation (EC:3.5.1.18UniRule annotation)
Short name:
SDAP desuccinylaseUniRule annotation
Alternative name(s):
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dapEUniRule annotation
Ordered Locus Names:HP_0212
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003755861 – 383Succinyl-diaminopimelate desuccinylaseAdd BLAST383

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O25002

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-3691N

Protein interaction database and analysis system

More...
IntActi
O25002, 1 interactor

Molecular INTeraction database

More...
MINTi
O25002

STRING: functional protein association networks

More...
STRINGi
85962.C694_01065

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O25002

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M20A family. DapE subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0624, Bacteria

Identification of Orthologs from Complete Genome Data

More...
OMAi
LNSHHDT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O25002

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01690, DapE, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001261, ArgE/DapE_CS
IPR036264, Bact_exopeptidase_dim_dom
IPR005941, DapE_proteobac
IPR002933, Peptidase_M20
IPR011650, Peptidase_M20_dimer

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07687, M20_dimer, 1 hit
PF01546, Peptidase_M20, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55031, SSF55031, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01246, dapE_proteo, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00759, ARGE_DAPE_CPG2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O25002-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDALEITQKL ISYPTITPKE CGIFEYIKSL FPHFKTLECG ENGVKNLFLY
60 70 80 90 100
RIFNPPKDHA EEKHAKENTK PLHFCFAGHI DVVPPGNHWQ SDPFKPVIKE
110 120 130 140 150
GFLYGRGAQD MKGGVGAFLS ASLNFNPKTP FLLSILLTSD EEGPGIFGTR
160 170 180 190 200
LMLEKLKEKD LLPHMAIVAE PTCEKVLGDS IKIGRRGSIN GKLILKGVQG
210 220 230 240 250
HVAYPQKCQN PIDTLASVLP LISGVNLDNG DEYFDPSKLV ITNLHAGLGA
260 270 280 290 300
NNITPASVEI IFNARHSLKT TKESLKEYLE KVLKDLPYTL ELESSSSPFI
310 320 330 340 350
TASHSKLTSV LKENILKTCH TTPLLNTKGG TSDARFFSAH GIEVVEFGVI
360 370 380
NDRIHAIDER VSLKELELLE KVFLGVLEGL SEA
Length:383
Mass (Da):42,243
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2FD4C64C8C9C051
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2D → N in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti33H → A in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti58D → EHAEKE in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti61E → K in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti69T → V in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti75C → S in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti87 – 88NH → DN in AAB63297 (PubMed:9317022).Curated2
Sequence conflicti97V → I in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti150R → K in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti192K → R in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti221L → S in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti226N → H in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti229N → D in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti241I → V in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti253I → V in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti256A → G in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti261I → T in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti288Y → H in AAB63297 (PubMed:9317022).Curated1
Sequence conflicti320H → R in AAB63297 (PubMed:9317022).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF008565 Genomic DNA Translation: AAB63297.1
AE000511 Genomic DNA Translation: AAD07280.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D64546

NCBI Reference Sequences

More...
RefSeqi
NP_207010.1, NC_000915.1
WP_000339189.1, NC_018939.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD07280; AAD07280; HP_0212

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpy:HP0212

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|85962.47.peg.229

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008565 Genomic DNA Translation: AAB63297.1
AE000511 Genomic DNA Translation: AAD07280.1
PIRiD64546
RefSeqiNP_207010.1, NC_000915.1
WP_000339189.1, NC_018939.1

3D structure databases

SMRiO25002
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-3691N
IntActiO25002, 1 interactor
MINTiO25002
STRINGi85962.C694_01065

Proteomic databases

PaxDbiO25002

Genome annotation databases

EnsemblBacteriaiAAD07280; AAD07280; HP_0212
KEGGihpy:HP0212
PATRICifig|85962.47.peg.229

Phylogenomic databases

eggNOGiCOG0624, Bacteria
OMAiLNSHHDT
PhylomeDBiO25002

Enzyme and pathway databases

UniPathwayiUPA00034;UER00021
BioCyciHPY:HP0212-MONOMER
BRENDAi3.5.1.18, 2604

Family and domain databases

HAMAPiMF_01690, DapE, 1 hit
InterProiView protein in InterPro
IPR001261, ArgE/DapE_CS
IPR036264, Bact_exopeptidase_dim_dom
IPR005941, DapE_proteobac
IPR002933, Peptidase_M20
IPR011650, Peptidase_M20_dimer
PfamiView protein in Pfam
PF07687, M20_dimer, 1 hit
PF01546, Peptidase_M20, 1 hit
SUPFAMiSSF55031, SSF55031, 1 hit
TIGRFAMsiTIGR01246, dapE_proteo, 1 hit
PROSITEiView protein in PROSITE
PS00759, ARGE_DAPE_CPG2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAPE_HELPY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O25002
Secondary accession number(s): O32633
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: January 1, 1998
Last modified: September 29, 2021
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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