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UniProtKB - O24933 (HRCA_HELPY)
Protein
Heat-inducible transcription repressor HrcA
Gene
hrcA
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
UniRule annotationGO - Molecular functioni
- DNA binding Source: InterPro
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Repressor |
Biological process | Stress response, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Heat-inducible transcription repressor HrcAUniRule annotation |
Gene namesi | Name:hrcAUniRule annotation Ordered Locus Names:HP_0111 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000182483 | 1 – 266 | Heat-inducible transcription repressor HrcAAdd BLAST | 266 |
Proteomic databases
PaxDbi | O24933 |
Interactioni
Protein-protein interaction databases
IntActi | O24933, 1 interactor |
MINTi | O24933 |
STRINGi | 85962.C694_00550 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the HrcA family.UniRule annotation
Phylogenomic databases
eggNOGi | COG1420, Bacteria |
OMAi | LCVGKLE |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
HAMAPi | MF_00081, HrcA, 1 hit |
InterProi | View protein in InterPro IPR002571, HrcA IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR34824, PTHR34824, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
i Sequence
Sequence statusi: Complete.
O24933-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRRIKVGSN LNKKESLLDA FVKTYLQILE PISSKRLKEL ADLKISCATI
60 70 80 90 100
RNYFQILSKE GMLYQAHSSG ARLPTFKAFE NYWQKSLRFE TLKVNEKRLK
110 120 130 140 150
SASENFGLFT LLKKPSLERL ERVIECEKRF LILDFLAFSC ALGYSVKMEK
160 170 180 190 200
FLLELVGRSV KEVRSIAASF NALSLARQLE RLEYSNTQIT RFNLMGLKTL
210 220 230 240 250
LNSPLFFDIL GGKVLERLSK GLHFIEPDCM LVTRPVEFQN KRMQLLCVGK
260
LECDYEGFFQ TISEEE
Sequence cautioni
The sequence AAD07182 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07182.1 Different initiation. |
PIRi | G64533 |
RefSeqi | NP_206911.1, NC_000915.1 |
Genome annotation databases
EnsemblBacteriai | AAD07182; AAD07182; HP_0111 |
KEGGi | hpy:HP_0111 |
PATRICi | fig|85962.8.peg.118 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07182.1 Different initiation. |
PIRi | G64533 |
RefSeqi | NP_206911.1, NC_000915.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | O24933, 1 interactor |
MINTi | O24933 |
STRINGi | 85962.C694_00550 |
Proteomic databases
PaxDbi | O24933 |
Genome annotation databases
EnsemblBacteriai | AAD07182; AAD07182; HP_0111 |
KEGGi | hpy:HP_0111 |
PATRICi | fig|85962.8.peg.118 |
Phylogenomic databases
eggNOGi | COG1420, Bacteria |
OMAi | LCVGKLE |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
HAMAPi | MF_00081, HrcA, 1 hit |
InterProi | View protein in InterPro IPR002571, HrcA IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR34824, PTHR34824, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HRCA_HELPY | |
Accessioni | O24933Primary (citable) accession number: O24933 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 30, 2000 | |
Last modified: | February 23, 2022 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families