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Protein

Phosphopentomutase

Gene

deoB

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphotransfer between the C1 and C5 carbon atoms of pentose.UniRule annotation

Catalytic activityi

Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.UniRule annotation
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 or 2 manganese ions.UniRule annotation

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Phosphopentomutase (deoB), Phosphopentomutase (deoB), Phosphopentomutase (deoB), Phosphopentomutase (deoB), Phosphopentomutase (deoB), Phosphopentomutase (deoB), Phosphopentomutase (deoB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi14ManganeseUniRule annotation1
Metal bindingi292ManganeseUniRule annotation1
Metal bindingi328ManganeseUniRule annotation1
Metal bindingi329ManganeseUniRule annotation1
Metal bindingi340ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00087;UER00173

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphopentomutaseUniRule annotation (EC:5.4.2.7UniRule annotation)
Alternative name(s):
PhosphodeoxyribomutaseUniRule annotation
Gene namesi
Name:deoBUniRule annotation
Synonyms:ppm
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998091 – 393PhosphopentomutaseAdd BLAST393

Structurei

3D structure databases

ProteinModelPortaliO24821
SMRiO24821
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphopentomutase family.UniRule annotation

Family and domain databases

CDDicd16009 PPM, 1 hit
Gene3Di3.30.70.1250, 1 hit
3.40.720.10, 1 hit
HAMAPiMF_00740 Phosphopentomut, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR010045 DeoB
IPR006124 Metalloenzyme
IPR024052 Phosphopentomutase_DeoB_cap_sf
PANTHERiPTHR21110 PTHR21110, 1 hit
PfamiView protein in Pfam
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001491 Ppentomutase, 1 hit
SUPFAMiSSF143856 SSF143856, 1 hit
SSF53649 SSF53649, 1 hit
TIGRFAMsiTIGR01696 deoB, 1 hit

Sequencei

Sequence statusi: Complete.

O24821-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPTCKRVFL IVMDSVGIGE APDAEKYNDK GADTLGHIAE HRGGLNMPNM
60 70 80 90 100
AKLGLSNIRE IEGIPKAEKP LAYYTKMQEA SAGKDTMTGH WELMGLRIDT
110 120 130 140 150
PFQVFPDGFP KELIDELEKQ TGRKVIGNKP ASGTAIIDEL GPEHMETGAL
160 170 180 190 200
IVYTSADSVL QIAAHEEVIP LEELYRICKI ARELTLDEKY MVGRVIARPF
210 220 230 240 250
IGTPGNFQRT ANRHDYALKP FGRTVMNELQ DAGYDVIAIG KIADIYDNEG
260 270 280 290 300
VTKTLRTKSN MDGMDKLVNT LQMNFTGLSF LNLVDFDALY GHRRDPKGYG
310 320 330 340 350
DALEEFDARL PEVFERLKED DLLIITADHG NDPVHHGTDH TREYVPLLVY
360 370 380 390
SPSMNGGKQL PLRETFADVG ATIAENFGVK MPKYGTSFLQ ELK
Length:393
Mass (Da):43,736
Last modified:January 1, 1998 - v1
Checksum:i4D739006C37BCEE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008120 Genomic DNA Translation: BAA22917.1
PIRiJE0180

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008120 Genomic DNA Translation: BAA22917.1
PIRiJE0180

3D structure databases

ProteinModelPortaliO24821
SMRiO24821
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00087;UER00173

Family and domain databases

CDDicd16009 PPM, 1 hit
Gene3Di3.30.70.1250, 1 hit
3.40.720.10, 1 hit
HAMAPiMF_00740 Phosphopentomut, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR010045 DeoB
IPR006124 Metalloenzyme
IPR024052 Phosphopentomutase_DeoB_cap_sf
PANTHERiPTHR21110 PTHR21110, 1 hit
PfamiView protein in Pfam
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001491 Ppentomutase, 1 hit
SUPFAMiSSF143856 SSF143856, 1 hit
SSF53649 SSF53649, 1 hit
TIGRFAMsiTIGR01696 deoB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEOB_GEOSE
AccessioniPrimary (citable) accession number: O24821
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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