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UniProtKB - O24534 (EF1A_VICFA)
Protein
Elongation factor 1-alpha
Gene
N/A
Organism
Vicia faba (Broad bean) (Faba vulgaris)
Status
Functioni
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 14 – 21 | GTPBy similarity | 8 | |
Nucleotide bindingi | 91 – 95 | GTPBy similarity | 5 | |
Nucleotide bindingi | 153 – 156 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
- translation elongation factor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Elongation factor |
Biological process | Protein biosynthesis |
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Elongation factor 1-alphaShort name: EF-1-alpha |
Organismi | Vicia faba (Broad bean) (Faba vulgaris) |
Taxonomic identifieri | 3906 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › fabids › Fabales › Fabaceae › Papilionoideae › 50 kb inversion clade › NPAAA clade › Hologalegina › IRL clade › Fabeae › Vicia |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090947 | 1 – 447 | Elongation factor 1-alphaAdd BLAST | 447 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 55 | N6,N6-dimethyllysineBy similarity | 1 | |
Modified residuei | 79 | N6,N6,N6-trimethyllysineBy similarity | 1 | |
Modified residuei | 187 | N6,N6,N6-trimethyllysineBy similarity | 1 | |
Modified residuei | 261 | N6-methyllysineBy similarity | 1 | |
Modified residuei | 289 | 5-glutamyl glycerylphosphorylethanolamineBy similarity | 1 | |
Modified residuei | 306 | N6,N6,N6-trimethyllysineBy similarity | 1 | |
Modified residuei | 362 | 5-glutamyl glycerylphosphorylethanolamineBy similarity | 1 | |
Modified residuei | 396 | N6,N6,N6-trimethyllysineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 230 | tr-type GAdd BLAST | 226 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 14 – 21 | G1By similarity | 8 | |
Regioni | 70 – 74 | G2By similarity | 5 | |
Regioni | 91 – 94 | G3By similarity | 4 | |
Regioni | 153 – 156 | G4By similarity | 4 | |
Regioni | 194 – 196 | G5By similarity | 3 |
Sequence similaritiesi
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.Curated
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_00118_A, EF_Tu_A, 1 hit |
InterProi | View protein in InterPro IPR004161, EFTu-like_2 IPR031157, G_TR_CS IPR027417, P-loop_NTPase IPR000795, T_Tr_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR009001, Transl_elong_EF1A/Init_IF2_C IPR004539, Transl_elong_EF1A_euk/arc IPR004160, Transl_elong_EFTu/EF1A_C |
Pfami | View protein in Pfam PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit PF03143, GTP_EFTU_D3, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF50465, SSF50465, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00483, EF-1_alpha, 1 hit |
PROSITEi | View protein in PROSITE PS00301, G_TR_1, 1 hit PS51722, G_TR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O24534-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKEKVHINI VVIGHVDSGK STTTGHLIYK LGGIDKRVIE RFEKEAAEMN
60 70 80 90 100
KRSFKYAWVL DKLKAERERG ITIDIALWKF ETSKYYCTVI DAPGHRDFIK
110 120 130 140 150
NMITGTSQAD CAVLIIDSTT GGFEAGISKD GQTREHALLA FTLGVKQMIC
160 170 180 190 200
CCNKMDATTP KYSKGRYEEI VKEVSSYLKK VGYNPDKIPF VPISGFEGDN
210 220 230 240 250
MIERSTNLDW YKGPTLLDAL DNINEPKRPS DKPLRLPLQD VYKIGGIGIV
260 270 280 290 300
PVGRVETGVV KPGMLVTFAP TGLTTEVKSV EMHHEALTEA LPGDNVGFNV
310 320 330 340 350
KNVAVKDLKR GFVASNSKDD PAKEAANFTS QVIIMNHPGQ IGNGYAPVLD
360 370 380 390 400
CHTSHIAVKF AELITKIDRR SGKEIEKEPK FLKNGDAGMV KMIPTKPMVV
410 420 430 440
ETFAEYPPLG RFAVRDMRQT VAVGVIKSVE KKDPTGAKVT KAAAKKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ222579 mRNA Translation: CAA10847.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ222579 mRNA Translation: CAA10847.1 |
3D structure databases
AlphaFoldDBi | O24534 |
SMRi | O24534 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_00118_A, EF_Tu_A, 1 hit |
InterProi | View protein in InterPro IPR004161, EFTu-like_2 IPR031157, G_TR_CS IPR027417, P-loop_NTPase IPR000795, T_Tr_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR009001, Transl_elong_EF1A/Init_IF2_C IPR004539, Transl_elong_EF1A_euk/arc IPR004160, Transl_elong_EFTu/EF1A_C |
Pfami | View protein in Pfam PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit PF03143, GTP_EFTU_D3, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SUPFAMi | SSF50447, SSF50447, 1 hit SSF50465, SSF50465, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00483, EF-1_alpha, 1 hit |
PROSITEi | View protein in PROSITE PS00301, G_TR_1, 1 hit PS51722, G_TR_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EF1A_VICFA | |
Accessioni | O24534Primary (citable) accession number: O24534 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |