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Protein

Myrcene synthase, chloroplastic

Gene

ag2

Organism
Abies grandis (Grand fir) (Pinus grandis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in defensive oleoresin formation in conifers in response to insect attack or other injury. Involved in monoterpene (C10) olefins biosynthesis.2 Publications

Miscellaneous

The conserved 64-Arg-Arg-65 motif may play a role in the isomerization step of the terpenoid cyclization reaction sequence.

Catalytic activityi

Geranyl diphosphate = myrcene + diphosphate.

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity, Mn2+By similarityNote: Binds 3 Mg2+ or Mn2+ ions per subunit.By similarity
  • K+

Pathwayi: oleoresin biosynthesis

This protein is involved in the pathway oleoresin biosynthesis, which is part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the pathway oleoresin biosynthesis and in Terpene metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi378Magnesium or manganese 1By similarity1
Metal bindingi378Magnesium or manganese 2By similarity1
Metal bindingi382Magnesium or manganese 1By similarity1
Metal bindingi382Magnesium or manganese 2By similarity1
Metal bindingi530Magnesium or manganese 3By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-12818
BRENDAi4.2.3.15 2
UniPathwayiUPA00924

Names & Taxonomyi

Protein namesi
Recommended name:
Myrcene synthase, chloroplastic (EC:4.2.3.15)
Alternative name(s):
Aggmyr
Gene namesi
Name:ag2
Synonyms:AG2.2
OrganismiAbies grandis (Grand fir) (Pinus grandis)
Taxonomic identifieri46611 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaPinidaePinalesPinaceaeAbies

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52ChloroplastSequence analysisAdd BLAST52
ChainiPRO_000003362753 – 627Myrcene synthase, chloroplasticAdd BLAST575

Proteomic databases

PRIDEiO24474

Expressioni

Inductioni

By wounding.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO24474
SMRiO24474
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi378 – 382DDXXD motif5

Domaini

The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.

Sequence similaritiesi

Belongs to the terpene synthase family. Tpsd subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK12467

Family and domain databases

Gene3Di1.10.600.10, 1 hit
1.50.10.130, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR034741 Terpene_cyclase_like_1_C
IPR001906 Terpene_synth_N
IPR036965 Terpene_synth_N_sf
IPR005630 Terpene_synthase_metal-bd
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF01397 Terpene_synth, 1 hit
PF03936 Terpene_synth_C, 1 hit
SFLDiSFLDG01019 Terpene_Cyclase_Like_1_C_Termi, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
SSF48576 SSF48576, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O24474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVSISPLA SKSCLRKSLI SSIHEHKPPY RTIPNLGMRR RGKSVTPSMS
60 70 80 90 100
ISLATAAPDD GVQRRIGDYH SNIWDDDFIQ SLSTPYGEPS YQERAERLIV
110 120 130 140 150
EVKKIFNSMY LDDGRLMSSF NDLMQRLWIV DSVERLGIAR HFKNEITSAL
160 170 180 190 200
DYVFRYWEEN GIGCGRDSIV TDLNSTALGF RTLRLHGYTV SPEVLKAFQD
210 220 230 240 250
QNGQFVCSPG QTEGEIRSVL NLYRASLIAF PGEKVMEEAE IFSTRYLKEA
260 270 280 290 300
LQKIPVSALS QEIKFVMEYG WHTNLPRLEA RNYIDTLEKD TSAWLNKNAG
310 320 330 340 350
KKLLELAKLE FNIFNSLQQK ELQYLLRWWK ESDLPKLTFA RHRHVEFYTL
360 370 380 390 400
ASCIAIDPKH SAFRLGFAKM CHLVTVLDDI YDTFGTIDEL ELFTSAIKRW
410 420 430 440 450
NSSEIEHLPE YMKCVYMVVF ETVNELTREA EKTQGRNTLN YVRKAWEAYF
460 470 480 490 500
DSYMEEAKWI SNGYLPMFEE YHENGKVSSA YRVATLQPIL TLNAWLPDYI
510 520 530 540 550
LKGIDFPSRF NDLASSFLRL RGDTRCYKAD RDRGEEASCI SCYMKDNPGS
560 570 580 590 600
TEEDALNHIN AMVNDIIKEL NWELLRSNDN IPMLAKKHAF DITRALHHLY
610 620
IYRDGFSVAN KETKKLVMET LLESMLF
Length:627
Mass (Da):72,479
Last modified:January 1, 1998 - v1
Checksum:i2E0DA492E0C971FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87908 mRNA Translation: AAB71084.1

Genome annotation databases

KEGGiag:AAB71084

Similar proteinsi

Entry informationi

Entry nameiTPSD2_ABIGR
AccessioniPrimary (citable) accession number: O24474
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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